Immunological evaluation of erythema nodosum in tularaemia

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dc.contributor.buuauthorAkdiş, Cezmi A.
dc.contributor.buuauthorKılıçturgay, Kaya
dc.contributor.buuauthorHelvacı, Safiye
dc.contributor.buuauthorMıstık, Reşit
dc.contributor.buuauthorOral, Haluk Barbaros
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0003-0463-6818tr_TR
dc.contributor.researcheridK-7285-2012tr_TR
dc.date.accessioned2021-07-02T05:58:28Z
dc.date.available2021-07-02T05:58:28Z
dc.date.issued1993
dc.description.abstractDuring two tularaemia outbreaks in the Bursa region of Turkey in 1991. a total of 9 8 patients were diagnosed and evaluated. Thirteen of these patients had erythema nodosum, which is accepted as a secondary skin manifestation. The patients with erythema nodosum, 21 patients without any skin lesions, and 20 healthy controls were studied. Comparable elevations of levels of IgG, IgA, and IgM were detected in the two tularaemia groups. There was no difference in complement C3c and C4 levels between the groups. All of the patients with erythema nodosum had elevated circulating immune complex (CIC) levels, when compared with the patients without skin lesions and the control group. The acute phase response (C-reactive protein [CRP] and erythrocyte sedimentation rate [ESR]) of the erythema nodosum group was significantly higher than the patients with normal skin, and healthy controls (P<0.001). Serum transferrin levels were significantly decreased in both of the tularaemia groups (P<0.001). Serum soluble interleukin-2 receptor levels (SIL-2R) were significantly elevated in both tularaemia groups (P<0.001), and the elevation was more marked in the erythema nodosum group (P<0.05). Histopathological evaluation of biopsies from two patients with erythema nodosum showed dermal oedema, a perivascular lymphocytic infiltrate, and panniculitis. No immunoglobulin or complement deposits were detected on immunofluorescence.en_US
dc.identifier.citationAkdiş, N. A. vd. (1993). ''Immunological evaluation of erythema nodosum in tularaemia''. British Journal of Dermatology, 129(3), 275-279.en_US
dc.identifier.endpage279tr_TR
dc.identifier.issn0007-0963
dc.identifier.issue3tr_TR
dc.identifier.pubmed8286224tr_TR
dc.identifier.scopus2-s2.0-0027366243tr_TR
dc.identifier.startpage275tr_TR
dc.identifier.urihttps://doi.org/10.1111/j.1365-2133.1993.tb11846.x
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2133.1993.tb11846.x
dc.identifier.urihttp://hdl.handle.net/11452/20969
dc.identifier.volume129tr_TR
dc.identifier.wosA1993LX31900008tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.journalBritish Journal of Dermatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSoluble interleukin-2 receptorsen_US
dc.subjectNecrosis-factor-alphaen_US
dc.subjectFrancisella-tularensisen_US
dc.subjectPulmonary tuberculosisen_US
dc.subjectGamma-Interferonen_US
dc.subjectTularemiaen_US
dc.subjectInfectionen_US
dc.subjectLeukemiaen_US
dc.subjectImmunityen_US
dc.subjectInvitroen_US
dc.subjectDermatologyen_US
dc.subject.wosDermatologyen_US
dc.titleImmunological evaluation of erythema nodosum in tularaemiaen_US
dc.typeArticle

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