Serum concentrations of human angiopoietin-like protein 3 in patients with nonalcoholic fatty liver disease: Association with insulin resistance

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dc.contributor.authorYılmaz, Yusuf Cem
dc.contributor.authorAtuğ, Özlen
dc.contributor.buuauthorUlukaya, Engin
dc.contributor.buuauthorDolar, Enver
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Gastroenteroloji Anabilim Dalı.tr_TR
dc.contributor.researcheridK-5792-2018tr_TR
dc.contributor.researcheridAAG-9177-2021tr_TR
dc.contributor.scopusid6602927353tr_TR
dc.contributor.scopusid6602075084tr_TR
dc.date.accessioned2021-12-02T09:20:35Z
dc.date.available2021-12-02T09:20:35Z
dc.date.issued2009-11
dc.description.abstractObjective Insulin resistance is considered a key feature of nonalcoholic fatty liver disease (NAFLD). In this setting, experimental studies have suggested a potential role of angiopoietin-like (ANGPTL) proteins in the pathogenesis of hepatic steatosis and the metabolic syndrome. In this study, we sought to investigate the plasma levels of ANGPTL protein 3 (ANGPTL3) - a liver-derived protein that modulates plasma triglyceride clearance - in patients with definite nonalcoholic steatohepatitis (NASH, n = 40), borderline NASH (n = 8), simple fatty liver (n = 9), and healthy controls without evidence of liver disease (n = 14). Methods Levels of ANGPTL3 were measured by enzyme-linked immunosorbent assay and compared in the four study groups. Moreover, concentrations of ANGPTL3 were assessed in relation to the general characteristics of the study participants and the results of liver biopsy. Results Levels of ANGPTL3 were significantly higher in patients with definite NASH (389 +/- 110 ng/ml, P < 0.05) and borderline NASH (433 +/- 70 ng/ml, P < 0.05) compared with controls (291 +/- 78 ng/ml). No significant differences were found in patients with simple fatty liver (321 +/- 119 ng/ml) as compared with controls. In correlation analyses of the entire study cohort, ANGPTL3 was significantly and positively associated with homeostatic model assessment for insulin resistance (r = 0.28, P < 0.05) but not with histological staging and pathological characteristics of NAFLD. Conclusion Although subject to future confirmation, our data suggest that ANGPTL3 levels are elevated in the more severe forms of NAFLD and could be associated with insulin resistance in this setting.en_US
dc.identifier.citationYılmaz, Y. vd. (2009). "Serum concentrations of human angiopoietin-like protein 3 in patients with nonalcoholic fatty liver disease: Association with insulin resistance". European Journal of Gastroenterology and Hepatology, 21(11), 1247-1251.en_US
dc.identifier.endpage1251tr_TR
dc.identifier.issn0954-691X
dc.identifier.issue11tr_TR
dc.identifier.pubmed19474742tr_TR
dc.identifier.scopus2-s2.0-70350142150tr_TR
dc.identifier.startpage1247tr_TR
dc.identifier.urihttps://doi.org/10.1097/MEG.0b013e32832b77ae
dc.identifier.urihttps://journals.lww.com/eurojgh/Fulltext/2009/11000/Serum_concentrations_of_human_angiopoietin_like.3.aspx
dc.identifier.urihttp://hdl.handle.net/11452/22957
dc.identifier.volume21tr_TR
dc.identifier.wos000271301100003tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.collaborationYurt içitr_TR
dc.relation.journalEuropean Journal of Gastroenterology and Hepatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAngiopoietin-like protein 3en_US
dc.subjectBiomarkersen_US
dc.subjectLiver injuryen_US
dc.subjectNonalcoholic fatty liver diseaseen_US
dc.subjectMetabolic syndromeen_US
dc.subjectAngptl3en_US
dc.subjectExpressionen_US
dc.subjectSecretionen_US
dc.subjectGastroenterology & hepatologyen_US
dc.subject.emtreeAlanine aminotransferaseen_US
dc.subject.emtreeAngiopoietinen_US
dc.subject.emtreeAngiopoietin like protein 3en_US
dc.subject.emtreeAspartate aminotransferase blood levelen_US
dc.subject.emtreeBiological markeren_US
dc.subject.emtreeInsulinen_US
dc.subject.emtreeLiver proteinen_US
dc.subject.emtreeRegulator proteinen_US
dc.subject.emtreeTriacylglycerolen_US
dc.subject.emtreeUnclassified drugen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAlanine aminotransferase blood levelen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeAspartate aminotransferase blood levelen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeCorrelation analysisen_US
dc.subject.emtreeDisease severityen_US
dc.subject.emtreeEchographyen_US
dc.subject.emtreeEnzyme linked immunosorbent assayen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeHuman tissueen_US
dc.subject.emtreeInsulin resistanceen_US
dc.subject.emtreeLiver biopsyen_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeNonalcoholic fatty liveren_US
dc.subject.emtreePathogenesisen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeProtein blood levelen_US
dc.subject.emtreeProtein functionen_US
dc.subject.emtreeRoc curveen_US
dc.subject.emtreeSensitivity and specificityen_US
dc.subject.meshAdulten_US
dc.subject.meshAngiopoietinsen_US
dc.subject.meshBiological markersen_US
dc.subject.meshBiopsyen_US
dc.subject.meshFatty liveren_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshInsulin resistanceen_US
dc.subject.meshLiveren_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle ageden_US
dc.subject.scopusAngiopoietin-like Proteins; Lipoprotein Lipase; Human ANGPTL2 Proteinen_US
dc.subject.wosGastroenterology & hepatologyen_US
dc.titleSerum concentrations of human angiopoietin-like protein 3 in patients with nonalcoholic fatty liver disease: Association with insulin resistanceen_US
dc.typeArticle

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