Comparison of the efficacy of 2 mg versus 5 mg tropisetron in the management of post-operative nausea and vomiting

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dc.contributor.authorKutlay, Özden
dc.contributor.buuauthorYılmazlar, Aysun
dc.contributor.buuauthorTokat, Oğuz
dc.contributor.buuauthorKutlay, Oya
dc.contributor.buuauthorYılmazlar, Tuncay
dc.contributor.buuauthorTürker, Gürkan
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Anesteziyoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-3019-581Xtr_TR
dc.contributor.researcheridAAG-9356-2021tr_TR
dc.contributor.researcheridAAI-6642-2021tr_TR
dc.contributor.scopusid6701388235tr_TR
dc.contributor.scopusid6603597913tr_TR
dc.contributor.scopusid6602199747tr_TR
dc.contributor.scopusid6701800362tr_TR
dc.contributor.scopusid7003400116tr_TR
dc.date.accessioned2022-01-10T12:41:12Z
dc.date.available2022-01-10T12:41:12Z
dc.date.issued2001
dc.description.abstractA randomized, double-blind, placebo-controlled study was carried out to investigate the efficacy of 2 mg versus 5 mg tropisetron in the prevention of postoperative nausea and vomiting. Patients between 22 and 64 years old who were undergoing surgery under general anaesthesia and who had been classified according to the American Society of Anesthesiologists criteria with physical status I or II were included in this trial. Sixty female patients were recruited and divided into three groups (n = 20 in each group). Patients in group 1 received saline solution as control, whereas in groups 2 and 3, 2 mg or 5 mg tropisetron, respectively, was administered intravenously as a single dose during the induction of anaesthesia. The number of patients vomiting within the first 2 h following the operation was significantly less in groups 2 and 3 compared with that in group 1 (one of 20 for each of the groups 2 and 3 versus 12 of 20 in group 1). Three patients required rescue anti-emetic medication in each of the groups 2 and 3. In conclusion, 2 mg tropisetron appears to be equally as efficacious as 5 mg in preventing post-operative nausea and vomiting.en_US
dc.identifier.citationYılmazlar, A. vd. (2001). "Comparison of the efficacy of 2 mg versus 5 mg tropisetron in the management of post-operative nausea and vomiting". Journal of International Medical Research, 29(5), 385-388.en_US
dc.identifier.endpage388tr_TR
dc.identifier.issn0300-0605
dc.identifier.issue5tr_TR
dc.identifier.pubmed11725824tr_TR
dc.identifier.scopus2-s2.0-0035149611tr_TR
dc.identifier.startpage385tr_TR
dc.identifier.urihttps://doi.org/10.1177/147323000102900501
dc.identifier.urihttps://journals.sagepub.com/doi/10.1177/147323000102900501
dc.identifier.urihttp://hdl.handle.net/11452/23975
dc.identifier.volume29tr_TR
dc.identifier.wos000172048300001tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherSage Publicationsen_US
dc.relation.collaborationYurt içitr_TR
dc.relation.journalJournal of International Medical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnti-emeticen_US
dc.subjectPost-operative nausea and vomitingen_US
dc.subjectTropisetronen_US
dc.subjectPost-operative nauseaen_US
dc.subjectPreventıonen_US
dc.subjectOndansetronen_US
dc.subjectResearch & experimental medicineen_US
dc.subjectPharmacology & pharmacyen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAnesthesia inductionen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeClinical trialen_US
dc.subject.emtreeComparative studyen_US
dc.subject.emtreeControlled clinical trialen_US
dc.subject.emtreeDrug costen_US
dc.subject.emtreeSerotonin 3 antagonisten_US
dc.subject.emtreeDouble blind procedureen_US
dc.subject.emtreeDrug efficacyen_US
dc.subject.emtreeExtrapyramidal symptomen_US
dc.subject.emtreeGeneral anesthesiaen_US
dc.subject.emtreePatient codingen_US
dc.subject.emtreeNausea and vomitingen_US
dc.subject.emtreeGeneral anesthesiaen_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreePostoperative complicationen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeIncidenceen_US
dc.subject.emtreeRandomized controlled trialen_US
dc.subject.emtreeSedationen_US
dc.subject.emtreeSide effecten_US
dc.subject.emtreeSurgeryen_US
dc.subject.emtreeAntiemetic agenten_US
dc.subject.emtreeDose responseen_US
dc.subject.emtreeMiddle ageden_US
dc.subject.emtreeNauseaen_US
dc.subject.emtreePostoperative complicationen_US
dc.subject.emtreeVomitingen_US
dc.subject.emtreeGranisetronen_US
dc.subject.emtreeMetoclopramideen_US
dc.subject.emtreeOndansetronen_US
dc.subject.emtreeSodium chlorideen_US
dc.subject.emtreeTropisetronen_US
dc.subject.emtreeAntiemetic agenten_US
dc.subject.emtreeIndole derivativeen_US
dc.subject.emtreeTropisetronen_US
dc.subject.meshAdulten_US
dc.subject.meshAnesthesia, generalen_US
dc.subject.meshAntiemeticsen_US
dc.subject.meshDouble-blind methoden_US
dc.subject.meshHumansen_US
dc.subject.meshDose-response relationship,drugen_US
dc.subject.meshIndolesen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshNauseaen_US
dc.subject.meshPostoperative complicationsen_US
dc.subject.meshVomitingen_US
dc.subject.scopusPostoperative Nausea and Vomiting; Palonosetron; Antiemeticsen_US
dc.subject.wosMedicine, research & experimentalen_US
dc.subject.wosPharmacology & pharmacyen_US
dc.titleComparison of the efficacy of 2 mg versus 5 mg tropisetron in the management of post-operative nausea and vomitingen_US
dc.typeArticle
dc.wos.quartileQ4en_US

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