Neuroproctective effects of ischemic tolerance (preconditioning) and postconditioning

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dc.contributor.buuauthorAlkan, Tülin
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Fizyoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0001-6466-5042tr_TR
dc.contributor.researcheridAAH-1792-2021tr_TR
dc.contributor.scopusid6601953747tr_TR
dc.date.accessioned2021-12-20T09:03:19Z
dc.date.available2021-12-20T09:03:19Z
dc.date.issued2009-10
dc.description.abstractElucidation of the endogenous cell survival pathways involved in ischemic tolerance (preconditioning) and postconditioning has significant clinical implications for preventing neuronal damage in susceptible patients. Ischemic tolerance is a phenomenon in which the brain protects itself against future injury by adapting to low doses of noxious insults. Ischemic postconditioning is defined as brief periods of reperfusion alternating with re-occlusion applied during the very early minutes of reperfusion that mechanically alters the hydrodynamics of reperfusion. Similar pathways and molecules play a role in pre-and postconditioning but their roles and timing are different in each conditioning. Understanding the neuroprotective effects of mechanisms underlying conditionings has been elusive, but NNMA receptor activation, nitric oxide, inflammatory cytokines, and suppression of the innate immune system appear to have a role. Reactive oxygen species and classical ligand stimuli play a role in postconditioning with KATP channels and protein kinase C pathways acting as mediators.en_US
dc.identifier.citationAlkan, T. (2009). "Neuroproctective effects of ischemic tolerance (preconditioning) and postconditioning". Turkish Neurosurgery, 19(4), 406-412.tr_TR
dc.identifier.endpage412tr_TR
dc.identifier.issn1019-5149
dc.identifier.issue4tr_TR
dc.identifier.pubmed19847763tr_TR
dc.identifier.scopus2-s2.0-77449145618tr_TR
dc.identifier.startpage406tr_TR
dc.identifier.urihttp://hdl.handle.net/11452/23408
dc.identifier.volume19tr_TR
dc.identifier.wos000271572900015tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.trdizinTrDizintr_TR
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherTürk Nöroşirürji Derneğitr_TR
dc.relation.journalTurkish Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNeuronal protectionen_US
dc.subjectPostconditioningen_US
dc.subjectPreconditioningen_US
dc.subjectFocal cerebral-ischemiaen_US
dc.subjectSpreading depressionen_US
dc.subjectNitric-oxideen_US
dc.subjectProtein-synthesisen_US
dc.subjectNeuronal damageen_US
dc.subjectRapid toleranceen_US
dc.subjectCytochrome-cen_US
dc.subjectInjuryen_US
dc.subjectStrokeen_US
dc.subjectHypothermiaen_US
dc.subjectNeurosciences & neurologyen_US
dc.subjectSurgeryen_US
dc.subject.emtreeNeuroprotective agenten_US
dc.subject.emtreeAnimalen_US
dc.subject.emtreeBrain ischemiaen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeIschemic preconditioningen_US
dc.subject.emtreeMetabolismen_US
dc.subject.emtreeMethodologyen_US
dc.subject.emtreePathophysiologyen_US
dc.subject.emtreeReviewen_US
dc.subject.meshAnimalsen_US
dc.subject.meshHumansen_US
dc.subject.meshHypoxia-ischemia, brainen_US
dc.subject.meshIschemic preconditioningen_US
dc.subject.meshNeuroprotective agentsen_US
dc.subject.scopusIschemic Preconditioning; Neuroprotection; Brain Ischemiaen_US
dc.subject.wosClinical neurologyen_US
dc.subject.wosSurgeryen_US
dc.titleNeuroproctective effects of ischemic tolerance (preconditioning) and postconditioningen_US
dc.typeReview
dc.wos.quartileQ4en_US

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