Anti-Aflatoxigenc potentials of two Nigerian herbs on albino rats

dc.contributor.authorFapohunda, Stephen Oyedele
dc.contributor.authorAkintewe, Tosin
dc.contributor.authorOlarinmoye, Ayodefi
dc.contributor.authorEzekiel, Chinbudu Ngozi
dc.date.accessioned2021-03-08T07:23:11Z
dc.date.available2021-03-08T07:23:11Z
dc.date.issued2009
dc.description.abstractThe anti-aflatoxigenic activity of methanolic and ethanolic extracts of Phyllanthus niruri and Pseudocedrella kotschyi were studied in male and female Wister albino rats fed with aflatoxin –contaminated chow (112ppb) for 20 d. Morbidity studies arising from the dietary aflatoxin were carried out. Packed Cell Volume (PCV), fasting blood sugar (FBS), haemoglobin concentration (HB), total white blood cells (WBC), and serum bilirubin (SB) were profiled.. Extracts from both herbs lowered the PCB, blood glucose, Hb, WBC and SB levels in the test male than in control at P<0.05 using the ANOVA test for significance. The ethanolic extracts of Pseudocedrella and the methanolic extract of Phyllanthus were the most effective anti-aflatoxigenic agents in the male as they reduced the blood parameter levels by 50% of the positive control. The results were not so in the females. Post-mortem examination revealed kidney discoloration and paleness, mild to moderate hepatomegaly and enlarged spleen in the positive control while test rats showed normal morphology for these organs. The 2 local herbs are good candidates for the management of aflatoxicosis in mammals.
dc.identifier.citationFapohunda, S. O. vd. (2009). "Anti-Aflatoxigenc potentials of two Nigerian herbs on albino rats". Journal of Biological and Environmental Sciences, 3(9), 81-90.
dc.identifier.endpage90
dc.identifier.issn1307-9530
dc.identifier.issn1308-2019
dc.identifier.issue9
dc.identifier.startpage81
dc.identifier.urihttps://dergipark.org.tr/tr/download/article-file/497796
dc.identifier.urihttp://hdl.handle.net/11452/17207
dc.identifier.volume3
dc.language.isoen
dc.publisherUludağ Üniversitesi
dc.relation.journalJournal of Biological and Environmental Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAflatoxin
dc.subjectAlbino rats
dc.subjectPseudocedrella
dc.subjectPhyllanthus
dc.subjectChow
dc.titleAnti-Aflatoxigenc potentials of two Nigerian herbs on albino rats
dc.typeArticle

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