Arginine vasopressin in the pathogenesis of febrile convulsion and temporal lobe epilepsy

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dc.contributor.buuauthorGüleç, Güliz Uyar
dc.contributor.buuauthorNoyan, Bilge
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Fizyoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0003-0863-1547tr_TR
dc.contributor.researcheridC-5730-2015tr_TR
dc.contributor.scopusid6602752303tr_TR
dc.contributor.scopusid6506333172tr_TR
dc.date.accessioned2022-01-05T10:47:08Z
dc.date.available2022-01-05T10:47:08Z
dc.date.issued2002-11-15
dc.description.abstractWe aimed to investigate the possible convulsant action of arginine vasopressin (AVP) in both a febrile convulsion model in rat pups and a temporal lobe epilepsy model in adult rats and to define the receptor type which mediates this effect. In rat pups, 125 ng V-2 receptor antagonist significantly prevented hyperthermic seizures, but did not affect seizure latency. In adult rats, the only effective dose and agent was 125 ng V-2 receptor antagonist, which prevented pilocarpine-induced status epilepticus, extended the status epilepticus latency and improved the 24 h survival rate. These data suggest that AVP has a convulsant activity in febrile convulsions and also in seizures independent of fever, and this effect is mediated by V-2 receptors.en_US
dc.identifier.citationGüleç, G. ve Noyan, B. (2002). "Arginine vasopressin in the pathogenesis of febrile convulsion and temporal lobe epilepsy". Neuroreport, 13(16), 2045-2048.en_US
dc.identifier.endpage2048tr_TR
dc.identifier.issn0959-4965
dc.identifier.issue6tr_TR
dc.identifier.pubmed12438923tr_TR
dc.identifier.scopus2-s2.0-0037113309tr_TR
dc.identifier.startpage2045tr_TR
dc.identifier.urihttps://doi.org/10.1097/00001756-200211150-00011
dc.identifier.urihttps://journals.lww.com/neuroreport/Fulltext/2002/11150/Arginine_vasopressin_in_the_pathogenesis_of.11.aspx
dc.identifier.urihttp://hdl.handle.net/11452/23868
dc.identifier.volume13tr_TR
dc.identifier.wos000179821600011tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.journalNeuroreporten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNeurosciences & neurologyen_US
dc.subjectArginine vasopressinen_US
dc.subjectConvulsanten_US
dc.subjectRaten_US
dc.subjectReceptoren_US
dc.subjectSeizureen_US
dc.subjectCentral-nervous-systemen_US
dc.subjectAcid-induced seizuresen_US
dc.subjectOxytocinen_US
dc.subjectReleaseen_US
dc.subjectRatsen_US
dc.subjectNeurosciences & neurologyen_US
dc.subject.emtreeVasopressin receptor antagonisten_US
dc.subject.emtreeArgipressinen_US
dc.subject.emtreeConvulsant agenten_US
dc.subject.emtreePilocarpineen_US
dc.subject.emtreeVasopressin V2 receptoren_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeAnimal modelen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDrug induced diseaseen_US
dc.subject.emtreeEpileptic stateen_US
dc.subject.emtreeFebrile convulsionen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeLatent perioden_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreePathogenesisen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeRaten_US
dc.subject.emtreeTemporal lobe epilepsyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnimals, newbornen_US
dc.subject.meshAnticonvulsantsen_US
dc.subject.meshRats, sprague-dawleyen_US
dc.subject.meshArginine vasopressinen_US
dc.subject.meshConvulsantsen_US
dc.subject.meshDisease models, animalen_US
dc.subject.meshEpilepsy, temporal lobeen_US
dc.subject.meshMaleen_US
dc.subject.meshPilocarpineen_US
dc.subject.meshSurvival rateen_US
dc.subject.meshStatus epilepticusen_US
dc.subject.meshRatsen_US
dc.subject.meshReceptors, vasopressinen_US
dc.subject.meshSeizures, febrileen_US
dc.subject.scopusFebrile Seizures; Status Epilepticus; Iron-Deficiency Anemiasen_US
dc.subject.wosNeurosciencesen_US
dc.titleArginine vasopressin in the pathogenesis of febrile convulsion and temporal lobe epilepsyen_US
dc.typeArticle
dc.wos.quartileQ2en_US

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