Apoptosis: Why and how does it occur in biology?

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dc.contributor.authorAçılan, Ceyda
dc.contributor.authorYılmaz, Yusuf
dc.contributor.buuauthorUlukaya, Engin
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyokimya.tr_TR
dc.contributor.researcheridK-5792-2018tr_TR
dc.contributor.scopusid6602927353tr_TR
dc.date.accessioned2021-10-21T11:25:49Z
dc.date.available2021-10-21T11:25:49Z
dc.date.issued2011-08
dc.description.abstractThe literature on apoptosis has grown tremendously in recent years, and the mechanisms that are involved in this programmed cell death pathway have been enlightened. It is now known that apoptosis takes place starting from early development to adult stage for the homeostasis of multicellular organisms, during disease development and in response to different stimuli in many different systems. In this review, we attempted to summarize the current knowledge on the circumstances and the mechanisms that lead to induction of apoptosis, while going over the molecular details of the modulator and mediators of apoptosis as well as drawing the lines between programmed and non-programmed cell death pathways. The review will particularly focus on Bcl-2 family proteins, the role of different caspases in the process of apoptosis, and their inhibitors as well as the importance of apoptosis during different disease states. Understanding the molecular mechanisms involved in apoptosis better will make a big impact on human diseases, particularly cancer, and its management in the clinics.en_US
dc.identifier.citationUlukaya, E. vd. (2011).“Apoptosis: Why and how does it occur in biology?”. Cell Biochemistry and Function, 29(6), 468-480.en_US
dc.identifier.endpage480tr_TR
dc.identifier.issn0263-6484
dc.identifier.issn1099-0844
dc.identifier.issue6tr_TR
dc.identifier.pubmed21773978tr_TR
dc.identifier.scopus2-s2.0-80051668693tr_TR
dc.identifier.startpage468tr_TR
dc.identifier.urihttps://doi.org/10.1002/cbf.1774
dc.identifier.urihttp://hdl.handle.net/11452/22428
dc.identifier.volume29tr_TR
dc.identifier.wos000294267100005tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.collaborationYurt içitr_TR
dc.relation.collaborationSanayitr_TR
dc.relation.journalCell Biochemıstry and Functionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectProgrammed cell deathen_US
dc.subjectApoptosisen_US
dc.subjectNecrosisen_US
dc.subjectApoptosis-inducing factors (Aifs)en_US
dc.subjectCaspaseinhibitor of apoptosis proteins (Iaps)en_US
dc.subjectBcl-2 familyen_US
dc.subjectX-Linked inhibitoren_US
dc.subjectApo-1/Fas receptor/ligand systemen_US
dc.subjectCaspase-cleaved cytokeratin-18en_US
dc.subjectBcl-2 family proteinsen_US
dc.subjectCells in-vitroen_US
dc.subjectFas-liganden_US
dc.subjectCytochrome-Cen_US
dc.subjectMitochondrial apoptosisen_US
dc.subjectChromosome-segregationen_US
dc.subjectBh3-only proteinsen_US
dc.subjectIntracisternal a-particlesen_US
dc.subject.emtree2 morpholino 8 phenylchromoneen_US
dc.subject.emtreeAntineoplastic agenten_US
dc.subject.emtreeApoptosis inhibitören_US
dc.subject.emtreeBAG 1 protein; BIM proteinen_US
dc.subject.emtreeCaspaseen_US
dc.subject.emtreeCaspase inhibitoren_US
dc.subject.emtreeCellular apoptosis susceptibility proteinen_US
dc.subject.emtreeCeramideen_US
dc.subject.emtreeFas antibodyen_US
dc.subject.emtreeFas associated death domain proteinen_US
dc.subject.emtreeGranzymeen_US
dc.subject.emtreeHLA DR3 antigenen_US
dc.subject.emtreeHLA DR4 antigenen_US
dc.subject.emtreeHLA DR5 antigenen_US
dc.subject.emtreeNavitoclaxen_US
dc.subject.emtreeNeuronal apoptosis inhibitory proteinen_US
dc.subject.emtreeNicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferaseen_US
dc.subject.emtreeObatoclaxen_US
dc.subject.emtreePerforinen_US
dc.subject.emtreeProtein BADen_US
dc.subject.emtreeProtein baxen_US
dc.subject.emtreeProtein bcl 2en_US
dc.subject.emtreeProtein Biden_US
dc.subject.emtreeProtein kinase B inhibitoren_US
dc.subject.emtreeProtein p53en_US
dc.subject.emtreeSurvivinen_US
dc.subject.emtreeUnclassified drugen_US
dc.subject.emtreeUnindexed drugen_US
dc.subject.emtreeX linked inhibitor of apoptosisen_US
dc.subject.emtreeX linked inhibitor of apoptosis antagonisten_US
dc.subject.emtreeAcquired immune deficiency syndromeen_US
dc.subject.emtreeApoptosisen_US
dc.subject.emtreeCaenorhabditis elegansen_US
dc.subject.emtreeCancer chemotherapyen_US
dc.subject.emtreeCarcinogenesisen_US
dc.subject.emtreeCell activationen_US
dc.subject.emtreeCell cycleen_US
dc.subject.emtreeCell deathen_US
dc.subject.emtreeCell divisionen_US
dc.subject.emtreeCell growthen_US
dc.subject.emtreeCell protectionen_US
dc.subject.emtreeCell stressen_US
dc.subject.emtreeCell survivalen_US
dc.subject.emtreeCell swellingen_US
dc.subject.emtreeCytolysisen_US
dc.subject.emtreeCytotoxic T lymphocyteen_US
dc.subject.emtreeDephosphorylationen_US
dc.subject.emtreeDisease courseen_US
dc.subject.emtreeDNA damageen_US
dc.subject.emtreeDNA fragmentationen_US
dc.subject.emtreeDrug bindingen_US
dc.subject.emtreeDrug mechanismen_US
dc.subject.emtreeDrug synthesisen_US
dc.subject.emtreeEndometriumen_US
dc.subject.emtreeEnzyme activationen_US
dc.subject.emtreeEnzyme substrateen_US
dc.subject.emtreeEpstein barr virüsen_US
dc.subject.emtreeGenetic transcriptionen_US
dc.subject.emtreeHomeostasisen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeIn vitro studyen_US
dc.subject.emtreeInsulin dependent diabetes mellitusen_US
dc.subject.emtreeInternucleosomal DNA fragmentationen_US
dc.subject.emtreeKeratinocyteen_US
dc.subject.emtreeMitochondrial activationen_US
dc.subject.emtreeMitosisen_US
dc.subject.emtreeMolecular biologyen_US
dc.subject.emtreeMultiple sclerosisen_US
dc.subject.emtreeNatural killer cellen_US
dc.subject.emtreeNatural killer T cellen_US
dc.subject.emtreeNecrosisen_US
dc.subject.emtreeNeoplasmen_US
dc.subject.emtreeNerve cellen_US
dc.subject.emtreeNerve degenerationen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreeOligomerizationen_US
dc.subject.emtreeOrgan transplantationen_US
dc.subject.emtreeOxidative stressen_US
dc.subject.emtreePapilloma virüsen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeProtein cleavageen_US
dc.subject.emtreeProtein dephosphorylationen_US
dc.subject.emtreeProtein secretionen_US
dc.subject.emtreeReviewen_US
dc.subject.emtreeThymusen_US
dc.subject.emtreeUmor necrosis factor receptor associated periodic syndromeen_US
dc.subject.meshApoptosisen_US
dc.subject.meshApoptosis inducing factoren_US
dc.subject.meshCaspasesen_US
dc.subject.meshHumansen_US
dc.subject.meshInhibitor of apoptosis proteinsen_US
dc.subject.meshNecrosisen_US
dc.subject.meshProto-Oncogene proteins c-bcl-2en_US
dc.subject.meshSignal transductionen_US
dc.subject.scopusMitochondrial Membranes; Bcl-2; Bax Protein (53-86)en_US
dc.subject.wosBiochemistry & molecular biologyen_US
dc.subject.wosCell biologyen_US
dc.titleApoptosis: Why and how does it occur in biology?en_US
dc.typeReview
dc.wos.quartileQ4 (Cell biology)en_US
dc.wos.quartileQ3 (Biochemistry & molecular biology)en_US

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