Protective effects of diltiazem and tadalafil on shock wave-induced kidney injury in rats

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dc.contributor.buuauthorÖzmerdiven, Gökhun
dc.contributor.buuauthorVuruşkan, Berna Aytaç
dc.contributor.buuauthorKaygısız, Onur
dc.contributor.buuauthorVuruşkan, Hakan
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-9790-7295tr_TR
dc.contributor.researcheridAAH-9746-2021tr_TR
dc.contributor.researcheridAAM-9726-2020tr_TR
dc.contributor.researcheridL-9439-2019tr_TR
dc.contributor.scopusid56497875900tr_TR
dc.contributor.scopusid56527372000tr_TR
dc.contributor.scopusid16637252400tr_TR
dc.contributor.scopusid6507328150tr_TR
dc.date.accessioned2023-02-09T10:30:55Z
dc.date.available2023-02-09T10:30:55Z
dc.date.issued2016-12-21
dc.description.abstractBACKGROUND: We aimed to compare the protective effects of tadalafil and diltiazem on renal histology after ischemia and reperfusion injury in a rat model of shock wave lithotripsy. METHODS: A total of 40 adult, male Sprague-Dawley rats were randomized into four groups as follows; control group (group C), group S (SWL + nephrectomy), group T (SWL + tadalafil given before nephrectomy) and group D (SWL + diltiazem given before nephrectomy). Both kidneys were evaluated regarding tubular damage, peritubular fibrosis and heat shock protein-70 (HSP-70) immune-expression of glomeruli, cortical and medullar collector tubules on light microscopy. RESULTS: HSP-70 levels of cortical and medullar collector tubules, tubular damage and peritubular fibrosis scores were decreased in group T compared with group S. Similarly, HSP-70 immunostaining levels on cortical and medullar collector tubules, tubular damage and peritubular fibrosis scores were decreased in group D compared with group S. No significant difference was detected between group D and group T for all parameters. CONCLUSION: As a result, shock waves induced renal cell damage due to increment of HSP-70 levels, morphological irregularity in tubules and increased peritubular fibrosis. Tadalafil and diltiazem had beneficial effects in decreasing renal tissue damage which was caused by SWLen_US
dc.identifier.citationÖzmerdiven, G. vd. (2017). ''Protective effects of diltiazem and tadalafil on shock wave-induced kidney injury in rats''. Bratislava Medical Journal, 118(4), 228-232.en_US
dc.identifier.endpage232tr_TR
dc.identifier.issn0006-9248
dc.identifier.issue4tr_TR
dc.identifier.pubmed28471234tr_TR
dc.identifier.scopus2-s2.0-85018886202tr_TR
dc.identifier.startpage228tr_TR
dc.identifier.urihttps://doi.org/10.4149/BLL_2017_045
dc.identifier.uri1336-0345
dc.identifier.urihttp://www.elis.sk/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=5189&category_id=135&option=com_virtuemart&vmcchk=1&Itemid=1
dc.identifier.urihttp://hdl.handle.net/11452/30939
dc.identifier.volume118tr_TR
dc.identifier.wos000401303100008tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherAepress Sroen_US
dc.relation.journalBratislava Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGeneral & internal medicineen_US
dc.subjectDiltiazemen_US
dc.subjectIschemia-reperfusion injuryen_US
dc.subjectHeat shock proteinen_US
dc.subjectShock wave lithotripsyen_US
dc.subjectRenal tubulesen_US
dc.subjectTadalafilen_US
dc.subjectRenal ischemia-reperfusionen_US
dc.subjectIschemia/reperfusion injuryen_US
dc.subjectTubular dysfunctionen_US
dc.subjectLithotripsyen_US
dc.subjectNifedipineen_US
dc.subjectCalciumen_US
dc.subjectAllopurinolen_US
dc.subjectMechanismsen_US
dc.subjectVerapamilen_US
dc.subjectPigen_US
dc.subject.emtreeDiltiazemen_US
dc.subject.emtreeProtective agenten_US
dc.subject.emtreeTadalafilen_US
dc.subject.emtreeAcute kidney injuryen_US
dc.subject.emtreeAdverse effectsen_US
dc.subject.emtreeAnimalen_US
dc.subject.emtreeCombination drug therapyen_US
dc.subject.emtreeDrug effectsen_US
dc.subject.emtreeGlomerulusen_US
dc.subject.emtreeInjuriesen_US
dc.subject.emtreeKidney tubuleen_US
dc.subject.emtreeLithotripsyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeNephrectomyen_US
dc.subject.emtreePathologyen_US
dc.subject.emtreeRaten_US
dc.subject.emtreeReperfusion injuryen_US
dc.subject.emtreeSprague dawley raten_US
dc.subject.meshAcute kidney injuryen_US
dc.subject.meshAnimalsen_US
dc.subject.meshDiltiazemen_US
dc.subject.meshDrug therapy, combinationen_US
dc.subject.meshKidney glomerulusen_US
dc.subject.meshKidney tubulesen_US
dc.subject.meshLithotripsyen_US
dc.subject.meshMaleen_US
dc.subject.meshNephrectomyen_US
dc.subject.meshProtective agentsen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, sprague-dawleyen_US
dc.subject.meshReperfusion injuryen_US
dc.subject.meshTadalafilen_US
dc.subject.scopusUltrasonic Lithotripsy; Shock Waves; Urolithiasisen_US
dc.subject.wosMedicine, general & internalen_US
dc.titleProtective effects of diltiazem and tadalafil on shock wave-induced kidney injury in ratsen_US
dc.typeArticle
dc.wos.quartileQ4en_US

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