In vitro genotoxicity evaluation of acetamiprid in CaCo-2 cells using the micronucleus, comet and gamma H2AX foci assays

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dc.contributor.buuauthorÇavaş, Tolga
dc.contributor.buuauthorCinkılıç, Nilufer
dc.contributor.buuauthorVatan, Özgür
dc.contributor.buuauthorYılmaz, Dilek
dc.contributor.buuauthorCoşkun, Mümün
dc.contributor.departmentUludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü.tr_TR
dc.contributor.orcid0000-0002-7687-3284tr_TR
dc.contributor.orcid0000-0002-3595-6286tr_TR
dc.contributor.researcheridAAH-3508-2021tr_TR
dc.contributor.researcheridO-7508-2015tr_TR
dc.contributor.researcheridAAH-5296-2021tr_TR
dc.contributor.scopusid6602989548tr_TR
dc.contributor.scopusid26533892300tr_TR
dc.contributor.scopusid16235098100tr_TR
dc.contributor.scopusid6701369462tr_TR
dc.contributor.scopusid57204274361tr_TR
dc.date.accessioned2022-03-29T07:17:42Z
dc.date.available2022-03-29T07:17:42Z
dc.date.issued2012-11
dc.description.abstractAcetamiprid is a member of the neonicotinoid group of insecticides commonly used against wide range of insect pests. In the present study, in vitro cytotoxicity and genotoxicity of technical grade acetamiprid was evaluated on the human intestinal CaCo-2 cells. Cytotoxicity was evaluated using the clonogenic survival and the results indicated that acetamiprid was cytotoxic on CaCo-2 cells. The cells were than treated with acetamiprid concentrations exhibit greater than 75% clonogenic survival for 24 h, to assess genotoxicity using the micronucleus, comet and gamma H2AX foci formation assays. Our results indicate that, under the experimental conditions used, acetamiprid has cytotoxic and genotoxic potential on human intestinal cells.en_US
dc.identifier.citationÇavaş, T. vd. (2012). "In vitro genotoxicity evaluation of acetamiprid in CaCo-2 cells using the micronucleus, comet and gamma H2AX foci assays". Pesticide Biochemistry and Physiology, 104(3), 212-217.en_US
dc.identifier.endpage217tr_TR
dc.identifier.issn0048-3575
dc.identifier.issn1095-9939
dc.identifier.issue3tr_TR
dc.identifier.scopus2-s2.0-84870299938tr_TR
dc.identifier.startpage212tr_TR
dc.identifier.urihttps://doi.org/10.1016/j.pestbp.2012.08.004
dc.identifier.urihttps://www.infona.pl/resource/bwmeta1.element.elsevier-07bcadee-7020-37f8-a8e2-45f0630a01cf
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0048357512001320
dc.identifier.urihttp://hdl.handle.net/11452/25401
dc.identifier.volume104tr_TR
dc.identifier.wos000313599900007tr_TR
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherAcademic Press Inc Elsevier Scienceen_US
dc.relation.bapUAP(F)/2010-22tr_TR
dc.relation.journalPesticide Biochemistry and Physiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiochemistry & Molecular Biologyen_US
dc.subjectEntomologyen_US
dc.subjectPhysiologyen_US
dc.subjectAcetamipriden_US
dc.subjectGenotoxicen_US
dc.subjectCaCo-2en_US
dc.subjectCometen_US
dc.subjectMicronucleusen_US
dc.subjectGamma H2AXen_US
dc.subjectDna-damageen_US
dc.subjectNeonicotinoid insecticidesen_US
dc.subjectHuman-lymphocytesen_US
dc.subjectCytotoxicityen_US
dc.subjectInductionen_US
dc.subjectPesticidesen_US
dc.subjectToxicologyen_US
dc.subjectRelevanceen_US
dc.subjectApoptosisen_US
dc.subjectToxicityen_US
dc.subjectHexapodaen_US
dc.subject.scopusNeonicotinoids; Imidacloprid; Acetamipriden_US
dc.subject.wosBiochemistry & molecular biologyen_US
dc.subject.wosEntomologyen_US
dc.subject.wosPhysiologyen_US
dc.titleIn vitro genotoxicity evaluation of acetamiprid in CaCo-2 cells using the micronucleus, comet and gamma H2AX foci assaysen_US
dc.typeArticle
dc.wos.quartileQ1 (Entomology)en_US
dc.wos.quartileQ3en_US

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