Stimulus properties of venlafaxine in a conditioned taste aversion procedure

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dc.contributor.authorKayır, Hakan
dc.contributor.authorAlıcı, Tevfik
dc.contributor.authorYıldırım, Murat
dc.contributor.authorUlusoy, Kemal Gökhan
dc.contributor.authorCeyhan, Mert
dc.contributor.authorÇelik, Turgay
dc.contributor.authorUzbay, Tayfun
dc.contributor.buuauthorGöktalay, Gökhan
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Farmakoloji ve Klinik Farmakoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0001-6261-4233tr_TR
dc.contributor.researcheridAAH-1448-2021tr_TR
dc.contributor.scopusid6508023759tr_TR
dc.date.accessioned2022-03-21T11:12:08Z
dc.date.available2022-03-21T11:12:08Z
dc.date.issued2008-10-31
dc.description.abstractConditioned stimulus properties of venlafaxine are still unknown. In the present study, the discriminative stimulus properties of venlafaxine by using a conditioned taste aversion procedure were investigated. Swiss Webster mice were allowed to reach water from 2 pipettes for 20 min (09:00-11:30 h), plus 30 min (15:3016:00 h), daily. During the 4 days, the test drugs [fluoxetine, escitalopram, tianeptine, reboxetine, and N omega-nitro-L-arginine methyl ester(L-NAME)l were injected to mice at least 1 h after they had first water session. On day 5, they consumed glucose solution(5%w/v) and immediately injected with conditioning drug (venlafaxine 32 mg/kg). On day 8, mice were allowed to make a choice between water and glucose solution. The amount of glucose consumption as a percentage of total fluid intakes was calculated for each animal. Significant reduction in glucose choice was defined as conditioned taste aversion. Venlafaxine (32 mg/kg) induced a robust conditioned taste aversion in mice. Pre-exposure to tianeptine (2.5-10 mg/kg), fluoxetine (10 mg/kg), escitalopram (32 mg/kg), and reboxetine (5 mg/kg) substituted for venlafaxine by preventing the conditioned taste aversion induced by venlafaxine. L-NAME did not substitute for venlafaxine. Substitution of venlafaxine by fluoxetine, tianeptine, escitalopram, and reboxetine provides further evidence that both 5-HT and noradrenaline reuptake inhibition may play an important role in the stimulus effect of venlafaxine.en_US
dc.identifier.citationKayır, H. vd. (2008). "Stimulus properties of venlafaxine in a conditioned taste aversion procedure". European Journal of Pharmacology, 596(1-3), 102-106.en_US
dc.identifier.endpage106tr_TR
dc.identifier.issn0014-2999
dc.identifier.issn1879-0712
dc.identifier.issue1-3tr_TR
dc.identifier.pubmed18786528tr_TR
dc.identifier.scopus2-s2.0-53049098693tr_TR
dc.identifier.startpage102tr_TR
dc.identifier.uri10.1016/j.ejphar.2008.08.015
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0014299908008893
dc.identifier.urihttp://hdl.handle.net/11452/25227
dc.identifier.volume596tr_TR
dc.identifier.wos000260484900015tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.collaborationYurt içitr_TR
dc.relation.collaborationSanayitr_TR
dc.relation.journalEuropean Journal of Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject(Mice)en_US
dc.subjectAntidepressanten_US
dc.subjectConditioned taste aversionen_US
dc.subjectEscitalopramen_US
dc.subjectFluoxetineen_US
dc.subjectI- nameen_US
dc.subjectReboxetineen_US
dc.subjectTianeptineen_US
dc.subjectVenlafaxineen_US
dc.subjectSerotonin reuptake inhibitoren_US
dc.subjectDiscriminative stimulusen_US
dc.subjectAntidepressanten_US
dc.subjectCitalopramen_US
dc.subjectDrugsen_US
dc.subjectPharmacology & pharmacyen_US
dc.subject.emtreeEscitalopramen_US
dc.subject.emtreeFluoxetineen_US
dc.subject.emtreeGlucoseen_US
dc.subject.emtreeN(g) nitroarginine methyl esteren_US
dc.subject.emtreeNoradrenalinen_US
dc.subject.emtreeReboxetineen_US
dc.subject.emtreeSerotoninen_US
dc.subject.emtreeTianeptineen_US
dc.subject.emtreeVenlafaxineen_US
dc.subject.emtreeAnimal behavioren_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDose responseen_US
dc.subject.emtreeDrug discriminationen_US
dc.subject.emtreeDrug effecten_US
dc.subject.emtreeDrug mechanismen_US
dc.subject.emtreeDrug substitutionen_US
dc.subject.emtreeFluid intakeen_US
dc.subject.emtreeGlucose intakeen_US
dc.subject.emtreeInstrumental conditioningen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMouseen_US
dc.subject.emtreeNeurotransmitter uptakeen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeStimulus responseen_US
dc.subject.emtreeSwiss Webster mouseen_US
dc.subject.emtreeTaste aversionen_US
dc.subject.meshAdrenergic uptake inhibitorsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntidepressive agentsen_US
dc.subject.meshAvoidance learningen_US
dc.subject.meshConditioning (psychology)en_US
dc.subject.meshCyclohexanolsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshNG-nitroarginine methyl esteren_US
dc.subject.meshNitric oxideen_US
dc.subject.meshNitric oxide synthaseen_US
dc.subject.meshSerotonin uptake inhibitorsen_US
dc.subject.meshTasteen_US
dc.subject.scopusPsychedelic Agent; Serotonin 2A Receptor; Lysergideen_US
dc.subject.wosPharmacology & pharmacyen_US
dc.titleStimulus properties of venlafaxine in a conditioned taste aversion procedureen_US
dc.typeArticle
dc.wos.quartileQ2en_US

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