Effects of extremely low-frequency magnetic field on caspase activities and oxidative stress values in rat brain

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dc.contributor.authorAkdağ, Mehmet Zülküf
dc.contributor.authorDaşdağ, Süleyman
dc.contributor.authorUzunlar, Ali Kemal
dc.contributor.authorTaşkın, Abdullah
dc.contributor.buuauthorUlukaya, Engin
dc.contributor.buuauthorKurt, Mustafa Ayberk
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Anatomi Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0003-3368-8123tr_TR
dc.contributor.researcheridAAR-4341-2020tr_TR
dc.contributor.researcheridK-5792-2018tr_TR
dc.contributor.scopusid6602927353tr_TR
dc.contributor.scopusid35603735000tr_TR
dc.date.accessioned2021-11-10T08:19:53Z
dc.date.available2021-11-10T08:19:53Z
dc.date.issued2010
dc.description.abstractThis study was aimed to investigate the effect of extremely low-frequency magnetic field (ELF-MF) on apoptosis and oxidative stress values in the brain of rat. Rats were exposed to 100 and 500 mu T ELF-MF, which are the safety standards of public and occupational exposure for 2 h/day for 10 months. Brain tissues were immunohistochemically stained for the active (cleaved) caspase-3 in order to measure the apoptotic index by a semi-quantitative scoring system. In addition, the levels of catalase (CAT), malondialdehyde (MDA), myeloperoxidase (MPO), total antioxidative capacity (TAC), total oxidant status (TOS), and oxidative stress index (OS!) were measured in rat brain. Final score of apoptosis and MPO activity were not significantly different between the groups. CAT activity decreased in both exposure groups (p<0.05), while TAC was found to be lower in ELF 500 group than those in ELF-100 and sham groups (p<0.05). MDA, TOS, and OSI values were found to be higher in ELF-500 group than those in ELF-100 and sham groups (p<0.05). In conclusion, apoptosis was not changed by long-term ELF-MF exposure, while both 100 and 500 mu T ELF-MF exposure induced toxic effect in the rat brain by increasing oxidative stress and diminishing antioxidant defense system.en_US
dc.identifier.citationAkdağ, M. Z. vd. (2010). "Effects of extremely low-frequency magnetic field on caspase activities and oxidative stress values in rat brain". Biological Trace Element Research, 138(1-3), 238-249.en_US
dc.identifier.endpage249tr_TR
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.issue1-3tr_TR
dc.identifier.pubmed20177816tr_TR
dc.identifier.scopus2-s2.0-78649326519tr_TR
dc.identifier.startpage238tr_TR
dc.identifier.urihttps://doi.org/10.1007/s12011-010-8615-3
dc.identifier.urihttps://link.springer.com/article/10.1007/s12011-010-8615-3
dc.identifier.urihttp://hdl.handle.net/11452/22614
dc.identifier.volume138tr_TR
dc.identifier.wos000284382500025tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherHumana Pressen_US
dc.relation.collaborationYurt içitr_TR
dc.relation.journalBiological Trace Element Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectExtremely low-frequency magnetic fielden_US
dc.subjectOxidative stressen_US
dc.subjectAntioxidant enzymeen_US
dc.subjectCaspase-3 activitiesen_US
dc.subjectBrainen_US
dc.subjectNitric-oxide productionen_US
dc.subjectFree-radical processesen_US
dc.subjectLipid-peroxidationen_US
dc.subjectAntioxidant activityen_US
dc.subjectApoptosisen_US
dc.subjectExposureen_US
dc.subjectPlasmaen_US
dc.subjectSystemen_US
dc.subjectRedoxen_US
dc.subjectLiveren_US
dc.subjectBiochemistry & molecular biologyen_US
dc.subjectEndocrinology & metabolismen_US
dc.subjectRattusen_US
dc.subjectToscana virusen_US
dc.subject.emtreeCaspase 3en_US
dc.subject.emtreeMalonaldehydeen_US
dc.subject.emtreeMyeloperoxidaseen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeAnimal tissueen_US
dc.subject.emtreeAntioxidant activityen_US
dc.subject.emtreeApoptosisen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBrain levelen_US
dc.subject.emtreeBrain tissueen_US
dc.subject.emtreeBrain toxicityen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeEnzyme activityen_US
dc.subject.emtreeExtremely low frequency magnetic fielden_US
dc.subject.emtreeFrequency modulationen_US
dc.subject.emtreeLong term exposureen_US
dc.subject.emtreeMagnetic fielden_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreeOxidative stressen_US
dc.subject.emtreeRaten_US
dc.subject.emtreeScoring systemen_US
dc.subject.emtreeSham procedureen_US
dc.subject.scopusExtremely Low Frequencies; Electromagnetic Fields; Overhead Power Lineen_US
dc.subject.wosBiochemistry & molecular biologyen_US
dc.subject.wosEndocrinology & metabolismen_US
dc.titleEffects of extremely low-frequency magnetic field on caspase activities and oxidative stress values in rat brainen_US
dc.typeArticle
dc.wos.quartileQ4en_US

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