Cytokine gene polymorphisms in Behçet's disease and their association with clinical and laboratory findings

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dc.contributor.authorÖzçimen, Ahmet Ata
dc.contributor.buuauthorDilek, Kamil
dc.contributor.buuauthorSancaoğlu, Hayriye
dc.contributor.buuauthorSaba, Davit
dc.contributor.buuauthorYücel, Ali
dc.contributor.buuauthorYurtkuran, Mustafa Abbas
dc.contributor.buuauthorYurtkuran, Merih
dc.contributor.buuauthorOral, Haluk Barbaros
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Nefroloji ve Romatoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Dermatoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Kalp Damar Cerrahisi Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0003-0463-6818tr_TR
dc.contributor.researcheridK-7285-2012tr_TR
dc.contributor.scopusid56005080200tr_TR
dc.contributor.scopusid35485529800tr_TR
dc.contributor.scopusid55987378200tr_TR
dc.contributor.scopusid57225839918tr_TR
dc.contributor.scopusid55408539300tr_TR
dc.contributor.scopusid7003389525tr_TR
dc.contributor.scopusid7004498001tr_TR
dc.date.accessioned2021-11-26T10:16:24Z
dc.date.available2021-11-26T10:16:24Z
dc.date.issued2009
dc.description.abstractThe association of the cytokine gene polymorphisms with the development of Behcet's Disease (BD) was investigated in this study. DNA samples were obtained from a Turkish population of 97 unrelated patients with BD, and 12 7 unrelated health), control subjects. All genotyping (IL-6, IL10, IFN-gamma, TGF-beta 1 and TNF-alpha) experiments were performed using sequence-specific primers PCR. The frequency of TGF-beta 1 codon 25 GG genotype was found significantly lower in BD patients compared to healthy control subjects. The IL-10 -1082 GA genotype was more frequent whereas the AA genotype was less common in the BD group compared to the control group. The association between clinial findings and cytokine gene polymorphisms was further investigated in the patients with BD. The frequency of IFN-gamma AA genotype was lower in the patients with genital ulcer. Additionally, it was found that the frequency of IL-6 -174 GG genotype was lower in the patients with Pathergy positivity. These results suggest that TGF-beta 1 and IL-10 gene polymorphisms may affect host susceptibility to BD. Also, to confirm the biological significance of our results, further studies should be performed on other population groups and in large number of cases.en_US
dc.identifier.citationDilek, K. vd. (2009). "Cytokine gene polymorphisms in Behçet's disease and their association with clinical and laboratory findings". Clinical and Experimental Rheumatology, 27(2), Supplement 53, 73-78.en_US
dc.identifier.endpage78tr_TR
dc.identifier.issn0392-856X
dc.identifier.issue2 Supplement 53en_US
dc.identifier.pubmed19796538tr_TR
dc.identifier.scopus2-s2.0-70350141054tr_TR
dc.identifier.startpage73tr_TR
dc.identifier.urihttp://hdl.handle.net/11452/22825
dc.identifier.volume27tr_TR
dc.identifier.wos000272424000015tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherClinical & Exper Rheumatologyen_US
dc.relation.bapT-2004/59tr_TR
dc.relation.collaborationYurt içitr_TR
dc.relation.journalClinical and Experimental Rheumatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCytokineen_US
dc.subjectGenotypingen_US
dc.subjectPCR-SSPen_US
dc.subjectBehcet's diseaseen_US
dc.subjectTGF-betaen_US
dc.subjectIL-10en_US
dc.subjectNecrosis-factor-alphaen_US
dc.subjectPromoter polymorphismsen_US
dc.subjectInterleukin-10 il-10en_US
dc.subjectSusceptibilityen_US
dc.subjectTnfen_US
dc.subjectGrowthen_US
dc.subjectSuppressionen_US
dc.subjectMonocytesen_US
dc.subjectCellsen_US
dc.subjectTh17en_US
dc.subjectRheumatologyen_US
dc.subject.emtreeGamma interferonen_US
dc.subject.emtreeInterleukin 10en_US
dc.subject.emtreeInterleukin 6en_US
dc.subject.emtreeTransforming growth factor beta1en_US
dc.subject.emtreeTumor necrosis factor alphaen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBehcet diseaseen_US
dc.subject.emtreeCodonen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDisease predispositionen_US
dc.subject.emtreeDNA determinationen_US
dc.subject.emtreeErythema nodosumen_US
dc.subject.emtreeEye diseaseen_US
dc.subject.emtreeGene frequencyen_US
dc.subject.emtreeGene sequenceen_US
dc.subject.emtreeGenetic associationen_US
dc.subject.emtreeGenetic susceptibilityen_US
dc.subject.emtreeGenital ulceren_US
dc.subject.emtreeGenotypeen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeLaboratory testen_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreePolymerase chain reactionen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeSingle nucleotide polymorphismen_US
dc.subject.meshBehcet syndromeen_US
dc.subject.meshCase-control studiesen_US
dc.subject.meshGene frequencyen_US
dc.subject.meshGenetic predisposition to diseaseen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHumansen_US
dc.subject.meshInterferon-gammaen_US
dc.subject.meshInterleukin-10en_US
dc.subject.meshInterleukin-6en_US
dc.subject.meshPolymorphism, single nucleotideen_US
dc.subject.meshTransforming growth factor beta1en_US
dc.subject.meshTumor necrosis factor-alphaen_US
dc.subject.scopusBehcet Syndrome; Uveitis; Infliximaben_US
dc.subject.wosRheumatologyen_US
dc.titleCytokine gene polymorphisms in Behçet's disease and their association with clinical and laboratory findingsen_US
dc.typeArticle
dc.wos.quartileQ3en_US

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