Normoglisemik obez hastalarda prolaktin ve insülin direnci ilişkisi
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Date
2003-01-30
Authors
Top, Cihan
Cingözbay, Bekir Yılmaz
Keskin, Özcan
Terekeci, Hakan
Önde, Mehmet Emin
Journal Title
Journal ISSN
Volume Title
Publisher
Uludağ Üniversitesi
Abstract
Bu çalışmada; normoglisemik obez hastalarda, insülin duyarlılığı ile serum prolaktin düzeyleri arasındaki ilişkiyi araştırmayı amaçladık. VKİ değişen oranlarda olan (VKİ=39,7±5,4) 36 olgu (22 obez ve 14 morbid obez) çalışmaya dahil edildi. Tüm olgulara; insülin duyarlılık indeksi, serum prolaktin düzeyleri ve antropometrik ölçümlerden oluşan tanısal protokol uygulandı. İnsülin duyarlılığı HOMA skoru ile ölçüldü. Korelasyon analizi, serum prolaktin düzeyleri ile HOMA-IR arasında (r=-0.25, p=0.27) herhangi bir ilişki olmadığını gösterdi. Serum prolaktin düzeyleri ile VKİ arasında (r=0.52, p<0.05) anlamlı bir bağlantı mevcuttu. Obez ve morbid obez hastalar arasında serum prolaktin düzeyleri yönünden anlamlı farklılık saptandı (p<0.05). Bu sonuçlar göstermiştir ki, vücut kitlesi arttıkça gözlenen dolaşımdaki prolaktin yüksekliği, insülin direncini yansıtmamaktadır. Obezite patogenezinde prolaktinin rolünün araştırıldığı daha ileriki çalışmalara ihtiyaç duyulmaktadır.
In the present study we aimed to investigate the correlation between insulin sensitivity and serum prolactin levels in normoglycemic obese patients. Thirty-six subjects, with varying degrees of BMI (BMI=39.7±5.4) (22 obese and 14 morbide obese patients) were included in this study. All subjects underwent a diagnostic protocol which included measurements of insulin sensitivity index, serum prolactin levels and anthropometric measures. The insulin sensitivity was measured by HOMA (Homeostasis Model Assessment) score. Correlation analysis showed that there was no significant relationship among serum prolactin levels and HOMA-IR (r=-0.25, p=0.27). There was a significant relationship among serum prolactin levels and BMI (r=0.52, p<0.05). There was a significant difference in serum prolactin levels between obese and morbide obese patients (p<0.05). These results show that the circulating prolactin elevation, which is observed during body mass increase, does not reflect insulin resistance. Further studies will be required to investigate the role of prolactin in obesity pathogenesis.
In the present study we aimed to investigate the correlation between insulin sensitivity and serum prolactin levels in normoglycemic obese patients. Thirty-six subjects, with varying degrees of BMI (BMI=39.7±5.4) (22 obese and 14 morbide obese patients) were included in this study. All subjects underwent a diagnostic protocol which included measurements of insulin sensitivity index, serum prolactin levels and anthropometric measures. The insulin sensitivity was measured by HOMA (Homeostasis Model Assessment) score. Correlation analysis showed that there was no significant relationship among serum prolactin levels and HOMA-IR (r=-0.25, p=0.27). There was a significant relationship among serum prolactin levels and BMI (r=0.52, p<0.05). There was a significant difference in serum prolactin levels between obese and morbide obese patients (p<0.05). These results show that the circulating prolactin elevation, which is observed during body mass increase, does not reflect insulin resistance. Further studies will be required to investigate the role of prolactin in obesity pathogenesis.
Description
Keywords
Obesite, Obesity, Prolaktin, Prolactin, İnsulin direnci, β-hücre indeksi, Insulin resistance, β-cell index
Citation
Top, C. vd. (2002). "Normoglisemik obez hastalarda prolaktin ve insülin direnci ilişkisi" Uludağ Üniversitesi Tıp Fakültesi Dergisi, 28(3),85-87.