Antioxidant treatment in dialysis patients - importance of ferritin

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dc.contributor.buuauthorErsoy, Alpaslan
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-0710-0923tr_TR
dc.contributor.researcheridAAH-5054-2021tr_TR
dc.contributor.scopusid35612977100tr_TR
dc.date.accessioned2021-08-23T11:26:50Z
dc.date.available2021-08-23T11:26:50Z
dc.date.issued2006
dc.description.abstractSir, Cardiovascular disease remains one of the leading causes of mortality in haemodialysis (HD) patients. Abnormal oxidative stress and impaired antioxidant defence may contribute to accelerated atherogenesis associated with uraemia. I read with interest the article by Fumeron et al. [1], reporting that short-term oral vitamin C supplementation did not modify well-defined oxidative/antioxidative stress and inflammation markers in HD patients. As stated, they did not evaluate the effect of long-term intravenous vitamin C supplementation with lower or higher doses on oxidative stress, nor the efficacy of co-administration of vitamin E. Iron is a powerful oxidizing substance. Ferritin may have other functions in addition to its well-described role in storing intracellular iron. Elevated ferritin levels are associated with an increased risk of atherosclerotic coronary artery disease and myocardial infarction. Recent proteomics and molecular biology studies have shown that ferritin levels in arteries are increased in diseased tissues [2]. Ferritin may be unregulated under particular physiological conditions and may act as a pro-oxidant. In the mammalian cell, iron stored in ferritin can participate in initiating lipid peroxidation [3]. High levels of serum ferritin may indicate iron overload. However, in many patients results may be elevated due to inflammation, even if iron stores are not increased. Limited evidence shows that elevated iron stores and high-dose intravenous iron therapy may increase morbidity and mortality in HD patients [4], and exacerbate increased oxidative stress in uraemic patients [5].en_US
dc.identifier.citationErsoy, A. (2006). ''Antioxidant treatment in dialysis patients - importance of ferritin''. Nephrology Dialysis Transplantation, 21(7), 2035-2036.,en_US
dc.identifier.endpage2036tr_TR
dc.identifier.issn0931-0509
dc.identifier.issue7tr_TR
dc.identifier.pubmed16504978tr_TR
dc.identifier.scopus2-s2.0-33745607304tr_TR
dc.identifier.startpage2035tr_TR
dc.identifier.urihttps://doi.org/10.1093/ndt/gfl050
dc.identifier.urihttps://academic.oup.com/ndt/article/21/7/2035/1821801
dc.identifier.urihttp://hdl.handle.net/11452/21528
dc.identifier.volume21tr_TR
dc.identifier.wos000238908600063tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherOxford Univ Pressen_US
dc.relation.journalNephrology Dialysis Transplantationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTransplantationen_US
dc.subjectUrology & nephrologyen_US
dc.subjectSerum ferritinen_US
dc.subjectHemodialysis-patientsen_US
dc.subjectOxidative stressen_US
dc.subject.emtreeIronen_US
dc.subject.emtreeFerritinen_US
dc.subject.emtreeAscorbic aciden_US
dc.subject.emtreeApha tocopherolen_US
dc.subject.emtreeVitamin supplementationen_US
dc.subject.emtreeUremiaen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeOxidative stressen_US
dc.subject.emtreeLipid peroxidationen_US
dc.subject.emtreeLetteren_US
dc.subject.emtreeIron overloaden_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeHemodialysisen_US
dc.subject.emtreeFerritin blood levelen_US
dc.subject.emtreeDrug megadoseen_US
dc.subject.emtreeDisease exacerbationen_US
dc.subject.emtreeDisease associationen_US
dc.subject.emtreeCardiovascular risken_US
dc.subject.emtreeAtherogenesisen_US
dc.subject.emtreeAntioxidant activityen_US
dc.subject.meshRenal dialysisen_US
dc.subject.meshOxidative stressen_US
dc.subject.meshOxidantsen_US
dc.subject.meshKidney failure, chronicen_US
dc.subject.meshIronen_US
dc.subject.meshInflammationen_US
dc.subject.meshHumansen_US
dc.subject.meshHemoglobinsen_US
dc.subject.meshFerritinsen_US
dc.subject.meshAtherosclerosisen_US
dc.subject.meshAscorbic aciden_US
dc.subject.meshAntioxidantsen_US
dc.subject.scopusHemodialysis; Ascorbic Acid Deficiency; Chronic Kidney Failureen_US
dc.subject.wosTransplantationen_US
dc.subject.wosUrology & nephrologyen_US
dc.titleAntioxidant treatment in dialysis patients - importance of ferritinen_US
dc.typeLetter
dc.wos.quartileQ1 (Urology & nephrology)en_US
dc.wos.quartileQ2 (Transplantation)en_US

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