Steroid receptor expression and HER-2/neu (c-erbB-2) oncoprotein in the uterus of cats with cystic endometrial hyperplasia-pyometra complex

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dc.contributor.authorSevimli, Alper
dc.contributor.buuauthorMısırlıoğlu, Deniz
dc.contributor.buuauthorNak, Deniz
dc.contributor.buuauthorNak, Yavuz
dc.contributor.buuauthorÖzyiğit, Musa Özgür
dc.contributor.buuauthorAkkoç, A. N.
dc.contributor.buuauthorCangül, Taci
dc.contributor.departmentUludağ Üniversitesi/Veteriner Fakültesi/Patoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0003-0537-2113tr_TR
dc.contributor.researcheridAAR-6478-2021tr_TR
dc.contributor.researcheridAAH-2873-2021tr_TR
dc.contributor.researcheridAAH-5494-2021tr_TR
dc.contributor.researcheridAAB-4360-2021tr_TR
dc.contributor.scopusid6507455482tr_TR
dc.contributor.scopusid9280090000tr_TR
dc.contributor.scopusid8615464000tr_TR
dc.contributor.scopusid55584229300tr_TR
dc.contributor.scopusid6602486125tr_TR
dc.date.accessioned2021-11-16T06:40:09Z
dc.date.available2021-11-16T06:40:09Z
dc.date.issued2006
dc.description.abstractThe presence of oestrogen-alpha receptor (ER), progesterone receptor (PR), and HER-2/neu (c-erbB-2) oncoprotein in the uterine walls of 10 healthy cats and 20 subjects with cystic endometrial hyperplasia-pyometra (CEH-P) were evaluated. Lesions were graded according to the severity of cystic dilation, hyperplasia and inflammation, and were classified as normal, mild uterine hyperplasia and severe uterine hyperplasia. The ER, PR and c-erbB-2 expression in the endometrium, glandular epithelium, stromal fibroblasts and myometrial smooth muscle cells was quantified by immunohistochemistry. The ER, PR and c-erbB-2 staining patterns differed between normal uteri and uteri with CEH-P. The ER expression was tended to be higher in the endometrial surface and glandular epithelium in the severe hyperplasia group (P > 0.05) and significantly lower in the mild hyperplasia cases compared with normal endometrium (P < 0.05), whereas the PR expression in both severe and mild hyperplasia cases tended to be higher in stromal cells and glandular epithelium than those in the normal uteri. C-erbB-2 immunoreactivity was observed only in the endometrial surface and glandular epithelium of the uterine wall and immunostaining was found to be highest in cases with severe hyperplasia. As a conclusion, we suggest that c-erbB-2 oncoprotein may play a role in the pathogenesis of the CEH together with the ER and PR in cats, and that ER does not have a role in the mechanism of pyometra, whereas PR plays a role in the pathogenesis of both CEH and pyometra.en_US
dc.identifier.citationMısırlıoğlu, D. vd. (2006). ''Steroid receptor expression and HER-2/neu (c-erbB-2) oncoprotein in the uterus of cats with cystic endometrial hyperplasia-pyometra complex''. Journal of Veterinary Medicine Series A: Physiology Pathology Clinical Medicine, 53(5), 225-229.en_US
dc.identifier.endpage229tr_TR
dc.identifier.issn0931-184X
dc.identifier.issue5tr_TR
dc.identifier.pubmed16737511tr_TR
dc.identifier.scopus2-s2.0-33745337545tr_TR
dc.identifier.startpage225tr_TR
dc.identifier.urihttps://doi.org/10.1111/j.1439-0442.2006.00822.x
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1111/j.1439-0442.2006.00822.x
dc.identifier.urihttp://hdl.handle.net/11452/22656
dc.identifier.volume53tr_TR
dc.identifier.wos000237783200002tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherWiley-Blackwell Publishingen_US
dc.relation.collaborationYurt içitr_TR
dc.relation.journalJournal of Veterinary Medicine Series A: Physiology Pathology Clinical Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectVeterinary sciencesen_US
dc.subjectCellsen_US
dc.subjectAlphaen_US
dc.subjectCanceren_US
dc.subjectBitchen_US
dc.subjectEstrogen-receptorsen_US
dc.subjectEpidermal growth-factoren_US
dc.subject.emtreeProgesterone receptoren_US
dc.subject.emtreeEstrogen receptoren_US
dc.subject.emtreeEpidermal growth factor receptor 2en_US
dc.subject.emtreeUterus diseaseen_US
dc.subject.emtreePathologyen_US
dc.subject.emtreeMetabolismen_US
dc.subject.emtreeImmunohistochemistryen_US
dc.subject.emtreeHospitalizationen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeEndometrium hyperplasiaen_US
dc.subject.emtreeCat diseaseen_US
dc.subject.emtreeCaten_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeAnimal diseaseen_US
dc.subject.emtreeAnimalen_US
dc.subject.meshUterine diseasesen_US
dc.subject.meshSeverity of Illness Indexen_US
dc.subject.meshReceptors, progesteroneen_US
dc.subject.meshReceptors, estrogenen_US
dc.subject.meshReceptor, erbB-2en_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshFemaleen_US
dc.subject.meshEndometrial hyperplasiaen_US
dc.subject.meshCatsen_US
dc.subject.meshCat diseasesen_US
dc.subject.meshAnimalsen_US
dc.subject.scopusPyometra; Bitches; Deslorelinen_US
dc.subject.wosVeterinary sciencesen_US
dc.titleSteroid receptor expression and HER-2/neu (c-erbB-2) oncoprotein in the uterus of cats with cystic endometrial hyperplasia-pyometra complexen_US
dc.typeArticle
dc.wos.quartileQ3en_US

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