Meropenem decreases serum level of valproic acid

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dc.contributor.buuauthorNacarküçük, Ergün
dc.contributor.buuauthorSağlam, Halil
dc.contributor.buuauthorOkan, Mehmet Sait
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0003-0710-5422tr_TR
dc.contributor.researcheridC-7392-2019tr_TR
dc.contributor.scopusid6602924559tr_TR
dc.contributor.scopusid35612700100tr_TR
dc.contributor.scopusid6701707256tr_TR
dc.date.accessioned2021-08-31T07:49:26Z
dc.date.available2021-08-31T07:49:26Z
dc.date.issued2004-09
dc.description.abstractConcomitant administration of meropenem has been reported to decrease serum level of valproic acid both in humans and in animals. This report describes three children who required simultaneous administration of valproic acid and meropenem. Meropenem rapidly decreased serum valproic acid concentration to sub-therapeutic levels in all three children, and serum valproic acid levels were returned to therapeutic levels in a short time after discontinuing simultaneous meropenem therapy. Valproic acid was not changed to another antiepileptic agent, because no seizure activity was observed. To our knowledge, this is the first case report on the simultaneous administration of meropenem and valproic acid in childhood. In conclusion, it is clear that concomitant meropenem administration decreases serum valproic acid concentration, and we believe that there may be no need to change the antiepileptic drug during this period, provided that the patient has no seizure. More detailed studies are required.en_US
dc.identifier.citationNacarküçük, E. vd. (2004). “Meropenem decreases serum level of valproic acid”. Pediatric Neurology, 31(3), 232-234.en_US
dc.identifier.endpage234tr_TR
dc.identifier.issn0887-8994
dc.identifier.issue3tr_TR
dc.identifier.pubmed15351028tr_TR
dc.identifier.scopus2-s2.0-4544265039tr_TR
dc.identifier.startpage232tr_TR
dc.identifier.urihttps://doi.org/10.1016/j.pediatrneurol.2004.03.014
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S088789940400219
dc.identifier.urihttp://hdl.handle.net/11452/21569
dc.identifier.volume31tr_TR
dc.identifier.wos000224077600016tr_TR
dc.indexed.pubmedPubmedtr_TR
dc.indexed.scopusScopustr_TR
dc.indexed.wosSCIEtr_TR
dc.language.isoenen_US
dc.publisherElsevier Scienceen_US
dc.relation.journalPediatric Neurologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNeurosciences & neurologyen_US
dc.subjectPediatricsen_US
dc.subjectSafety profileen_US
dc.subjectCarbapenemen_US
dc.subjectPharmacokineticsen_US
dc.subjectPanipenemen_US
dc.subjectRabbitsen_US
dc.subjectPlasmaen_US
dc.subjectRatsen_US
dc.subject.emtreeCeftazidimeen_US
dc.subject.emtreeMeropenemen_US
dc.subject.emtreeTobramycinen_US
dc.subject.emtreeValproic aciden_US
dc.subject.emtreeVancomycinen_US
dc.subject.emtreeAdolescenten_US
dc.subject.emtreeCase reporten_US
dc.subject.emtreeCerebral palsyen_US
dc.subject.emtreeChilden_US
dc.subject.emtreeClinical featureen_US
dc.subject.emtreeDose calculationen_US
dc.subject.emtreeDrug blood levelen_US
dc.subject.emtreeDrug brain levelen_US
dc.subject.emtreeDrug glucuronidationen_US
dc.subject.emtreeDrug withdrawalen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeHospital admissionen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreePatient monitoringen_US
dc.subject.emtreePneumoniaen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeSeizureen_US
dc.subject.emtreeSeizure susceptibilityen_US
dc.subject.meshAdolescenten_US
dc.subject.meshDrug interactionsen_US
dc.subject.meshDrug therapy, combinationen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshInfanten_US
dc.subject.meshMaleen_US
dc.subject.meshThienamycinsen_US
dc.subject.meshValproic aciden_US
dc.subject.scopusCarbapenems; Valproic Acid; Acylamino Acid Releasing Enzymeen_US
dc.subject.wosClinical neurologyen_US
dc.subject.wosPediatricsen_US
dc.titleMeropenem decreases serum level of valproic aciden_US
dc.typeArticle
dc.wos.quartileQ2 (Pediatrics)en_US
dc.wos.quartileQ3 (Clinical neurology)en_US

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