The expression of fragile sites in lymphocytes of patients with rectum cancer and their first-degree relatives

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dc.contributor.buuauthorTunca, Berrin
dc.contributor.buuauthorEgeli, Ünal
dc.contributor.buuauthorZorluoğlu, Abdullah
dc.contributor.buuauthorYılmazlar, Tuncay
dc.contributor.buuauthorYerci, Ömer
dc.contributor.buuauthorKızıl, Ayhan
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Cerrahi Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Cerrahi Patoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-1619-6680tr_TR
dc.contributor.researcheridABI-6078-2020tr_TR
dc.date.accessioned2021-07-06T06:23:50Z
dc.date.available2021-07-06T06:23:50Z
dc.date.issued2000-05-01
dc.description.abstractFragile sites are non-staining gaps and breaks in specific points of chromosomes. These sites also include acentric fragments, triradial figures and several rearrangements. Although this issue has been controversial recently, they may be related to structural chromosomal rearrangement in some neoplasms. In this study, the expression of fragile sites induced by aphidicolin (Apc), 5-bromodeoxyuridine (BrJU) and caffeine was investigated on prometaphase chromosomes obtained from the peripheral blood lymphocytes of 36 patients with rectum cancer, 30 first-degree relatives and 30 normal healthy controls. The results of the structural chromosome aberrations determined in patients and their first-degree relatives were significantly higher than those in control subjects (P < 0.001). We determined aphidicolin type common fragile sites (1p36, 1p31, 1p21, 1q21, 1q25, 1q44, 2p24, 2q21, 2q33, 2q37, 3p14, 5q21, 5q33, 13q13, 14q24, 16q23 and 18q21). When the rates of sites such as 1p21, 1q25, 2q33, 3p14, 5q21 and 14q24 in patients and in their first-degree relatives were compared with the control group, the difference was statistically significant. Our results indicated an increased genetic instability in patients with rectum cancer and their first degree relatives. Therefore, the increase of fragile site expression may be an important marker showing genetic predisposition to rectum cancer.en_US
dc.identifier.citationTunca, B. vd. (2000). "The expression of fragile sites in lymphocytes of patients with rectum cancer and their first-degree relatives". Cancer Letters, 152(2), 201-209.en_US
dc.identifier.endpage209tr_TR
dc.identifier.issn0304-3835
dc.identifier.issue2tr_TR
dc.identifier.pubmed10773413tr_TR
dc.identifier.scopus2-s2.0-0034194842tr_TR
dc.identifier.startpage201tr_TR
dc.identifier.urihttps://doi.org/10.1016/S0304-3835(00)00334-7
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0304383500003347
dc.identifier.urihttp://hdl.handle.net/11452/21097
dc.identifier.volume152tr_TR
dc.identifier.wos000166661300013tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherElsevier Sci Irelanden_US
dc.relation.journalCancer Lettersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOncologyen_US
dc.subjectLung cancersen_US
dc.subjectFragile sitesen_US
dc.subjectHomozygous deletionsen_US
dc.subjectRectum canceren_US
dc.subjectColorectal-canceren_US
dc.subjectGenetic susceptibilityen_US
dc.subjectRenal-cellen_US
dc.subjectTumor-cell linesen_US
dc.subjectHeterozygosityen_US
dc.subjectFhit geneen_US
dc.subjectChromosome-3en_US
dc.subjectShort armen_US
dc.subjectBreast-canceren_US
dc.subject.wosOncologyen_US
dc.titleThe expression of fragile sites in lymphocytes of patients with rectum cancer and their first-degree relativesen_US
dc.typeArticle
dc.wos.quartileQ3en_US

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