Total and acylated ghrelin levels in type 2 diabetic patients: Similar levels observed after treatment with metformin, pioglitazone or diet therapy

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dc.contributor.buuauthorKıyıcı, Sinem
dc.contributor.buuauthorErsoy, Canan
dc.contributor.buuauthorGül, Özen Öz
dc.contributor.buuauthorSarandol, Emre
dc.contributor.buuauthorDemirci, Musa
dc.contributor.buuauthorTuncel, Ercan
dc.contributor.buuauthorSığırlı, Deniz
dc.contributor.buuauthorErtürk, Erdinç
dc.contributor.buuauthorİmamoğlu, Sazi
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/ndokrinoloji ve Metabolizma Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-2593-7196tr_TR
dc.contributor.researcheridAAH-8861-2021tr_TR
dc.contributor.researcheridAAJ-6536-2021tr_TR
dc.contributor.researcheridABE-1716-2020tr_TR
dc.contributor.researcheridAAI-1005-2021tr_TR
dc.contributor.researcheridAAA-7472-2021tr_TR
dc.contributor.scopusid12753880400tr_TR
dc.contributor.scopusid6701485882tr_TR
dc.contributor.scopusid26040787100tr_TR
dc.contributor.scopusid55943324800tr_TR
dc.contributor.scopusid18534643800tr_TR
dc.contributor.scopusid7006929833tr_TR
dc.contributor.scopusid24482063400tr_TR
dc.contributor.scopusid7005488796tr_TR
dc.contributor.scopusid6602297533tr_TR
dc.date.accessioned2022-01-11T11:34:48Z
dc.date.available2022-01-11T11:34:48Z
dc.date.issued2009-09
dc.description.abstractGhrelin, a potent gut-brain orexigenic peptide, has a role in stimulation of food intake and long-term regulation of body weight. Metformin and pioglitazone treatment have different effects on body weight. This discrepancy might be related with the effect of these two drugs on plasma ghrelin levels. We investigated the effect of these two drugs on post-prandial acylated and total ghrelin levels in patients with type 2 diabetes. Eleven patients treated with diet, 12 patients treated with 850 mg/day metformin monotherapy and 12 patients treated with 30 mg/day pioglitazone monotherapy for at least 6 months were enrolled in the study. Plasma acylated and total ghrelin levels were investigated at baseline and at the 60(th), 120(th), 180(th), 240(th) minutes after a mixed meal test. There were no differences between groups in any of baseline metabolic and anthropometric parameters, including acylated and total ghrelin levels. Acylated and total ghrelin concentrations were suppressed similarly after food consumption, and we could not determine any significant difference between the groups at any time interval. A prolonged postprandial suppression of acylated ghrelin concentrations was observed in the pioglitazone treatment group compared with baseline values. In conclusion, total and acylated ghrelin levels after a mixed meal test were similar in type 2 diabetic patients treated with metformin, pioglitazone or diet therapy alone. These results suggest that changes in body weight during metformin and pioglitazone treatment are not associated with plasma ghrelin levels.en_US
dc.identifier.citationKıyıcı, S. vd. (2009). "Total and acylated ghrelin levels in type 2 diabetic patients: Similar levels observed after treatment with metformin, pioglitazone or diet therapy". Experimental and Clinical Endocrinology and Diabetes, 117(8), 386-390.en_US
dc.identifier.endpage390tr_TR
dc.identifier.issn0947-7349
dc.identifier.issue8tr_TR
dc.identifier.pubmed19629933tr_TR
dc.identifier.scopus2-s2.0-70350443793tr_TR
dc.identifier.startpage386tr_TR
dc.identifier.urihttps://doi.org/10.1055/s-0029-1220936
dc.identifier.urihttps://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0029-1220936
dc.identifier.urihttp://hdl.handle.net/11452/24009
dc.identifier.volume117tr_TR
dc.identifier.wos000270680100004tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherJohann Ambrosius Barth Verlagde
dc.relation.journalExperimental and Clinical Endocrinology and Diabetesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGhrelinen_US
dc.subjectMetforminen_US
dc.subjectPioglitazoneen_US
dc.subjectType 2 diabetesen_US
dc.subjectCirculating ghrelinen_US
dc.subjectFood-intakeen_US
dc.subjectHigh-carbohydrateen_US
dc.subjectInsulin therapyen_US
dc.subjectWeight-gainen_US
dc.subjectHigh-faten_US
dc.subjectHormoneen_US
dc.subjectPeptideen_US
dc.subjectResponsesen_US
dc.subjectStomachen_US
dc.subjectEndocrinology & metabolismen_US
dc.subject.emtreeGhrelinen_US
dc.subject.emtreeMetforminen_US
dc.subject.emtreePioglitazoneen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAnthropometryen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBody weighten_US
dc.subject.emtreeClinical articleen_US
dc.subject.emtreeControl groupen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDiet therapyen_US
dc.subject.emtreeDrug blood levelen_US
dc.subject.emtreeDrug effecten_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeFood intakeen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMonotherapyen_US
dc.subject.emtreeNon insulin dependent diabetes mellitusen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeTreatment durationen_US
dc.subject.meshAcylationen_US
dc.subject.meshBlood glucoseen_US
dc.subject.meshBody mass indexen_US
dc.subject.meshBody weighten_US
dc.subject.meshDiabetes mellitus, type 2en_US
dc.subject.meshFemaleen_US
dc.subject.meshGhrelinen_US
dc.subject.meshHumansen_US
dc.subject.meshHypoglycemic agentsen_US
dc.subject.meshMaleen_US
dc.subject.meshMetforminen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshPostprandial perioden_US
dc.subject.meshSatiety responseen_US
dc.subject.meshThiazolidinedionesen_US
dc.subject.meshTime factorsen_US
dc.subject.scopusGhrelin Receptors; Acyltransferases; Growth Hormone Releasing Hexapeptideen_US
dc.subject.wosEndocrinology & metabolismen_US
dc.titleTotal and acylated ghrelin levels in type 2 diabetic patients: Similar levels observed after treatment with metformin, pioglitazone or diet therapyen_US
dc.typeArticle
dc.wos.quartileQ4en_US

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