In vitro phannacodynaniics of enrofloxacin against an Escherichia coli gyrA mutant

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dc.contributor.buuauthorCengiz, Murat
dc.contributor.buuauthorSorucu, Ali
dc.contributor.buuauthorArslan, Erdem
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Farmakoloji ve Toksikoloji Anabilim Dalı.tr_TR
dc.contributor.researcheridABE-5935-2020tr_TR
dc.contributor.scopusid16635026700tr_TR
dc.contributor.scopusid55236738400tr_TR
dc.contributor.scopusid55236493200tr_TR
dc.date.accessioned2022-10-07T12:57:23Z
dc.date.available2022-10-07T12:57:23Z
dc.date.issued2011
dc.description.abstractThe aim of this study was to investigate in vitro the pharmacodynamics of Enrofloxacin (ENR) against an Escherichia coli gyrA mutant (E. coli MT/128). Broth microdilution testing was used to determine the Minimum Inhibitory Concentration (MIC) and multi-step resistance selection was performed until reaching 1 mu g ML(-1) MIC. For time-kill experiments, colony counts were determined by plating each diluted sample onto Plate Count Agar and an integrated pharmacokinetic/pharmacodynamics area measure (log ratio area) was applied to all cfu data. A single C-T mutation was found in gyrA at codon 83. Concentration-dependent bacterial killing was observed for E. coli MT/128. Bactericidal activity for this strain was achieved within 4 h at concentrations >= 8 times the MIC with no significant regrowth by 24 h.en_US
dc.description.sponsorshipEuropean Cooperation in Science and Technology (COST) BM0701en_US
dc.identifier.citationCengiz, M. vd. (2011). "In vitro phannacodynaniics of enrofloxacin against an Escherichia coli gyrA mutant". Journal of Animal and Veterinary Advances, 10(18), 2384-2388.en_US
dc.identifier.endpage2388tr_TR
dc.identifier.issn1680-5593
dc.identifier.issue18tr_TR
dc.identifier.scopus2-s2.0-84872149544tr_TR
dc.identifier.startpage2384tr_TR
dc.identifier.urihttps://doi.org/10.3923/javaa.2011.2384.2388
dc.identifier.urihttps://medwelljournals.com/abstract/?doi=javaa.2011.2384.2388
dc.identifier.urihttp://hdl.handle.net/11452/29030
dc.identifier.volume10tr_TR
dc.identifier.wos000298094500009tr_TR
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherMedwell Onlineen_US
dc.relation.collaborationSanayitr_TR
dc.relation.journalJournal of Animal and Veterinary Advancesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.relation.tubitakTOVAG-110O478tr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectVeterinary sciencesen_US
dc.subjectPharmacodynamic of enrofloxacinen_US
dc.subjectEscherichia colien_US
dc.subjectC-T mutationen_US
dc.subjectSignificanten_US
dc.subjectMicrodilutionen_US
dc.subjectTurkeyen_US
dc.subjectColony-variant phenotypeen_US
dc.subjectFluoroquinolone resistanceen_US
dc.subjectStaphylococcus-aureusen_US
dc.subjectStreptococcus-pneumoniaeen_US
dc.subjectQuinolone resistanceen_US
dc.subjectMechanismsen_US
dc.subjectMutationsen_US
dc.subjectSelectionen_US
dc.subjectAnimalsen_US
dc.subjectModelen_US
dc.subject.scopusEscherichia Coli; Plasmids; Enterobacteriaceaeen_US
dc.subject.wosVeterinary sciencesen_US
dc.titleIn vitro phannacodynaniics of enrofloxacin against an Escherichia coli gyrA mutanten_US
dc.typeArticle

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