Genome-wide association mapping for identification of quantitative trait loci for rectal temperature during heat stress in holstein cattle

Simple item page
dc.contributor.authorCole, John B.
dc.contributor.authorNull, Daniel J.
dc.contributor.authorHansen, Peter J.
dc.contributor.buuauthorDikmen, Serdal
dc.contributor.departmentUludağ Üniversitesi/Veterinerlik Fakültesi/Hayvan Bilimleri Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-5611-4993tr_TR
dc.contributor.researcheridA-5731-2018tr_TR
dc.contributor.scopusid8280302600tr_TR
dc.date.accessioned2022-10-06T08:12:37Z
dc.date.available2022-10-06T08:12:37Z
dc.date.issued2013-07-23
dc.description.abstractHeat stress compromises production, fertility, and health of dairy cattle. One mitigation strategy is to select individuals that are genetically resistant to heat stress. Most of the negative effects of heat stress on animal performance are a consequence of either physiological adaptations to regulate body temperature or adverse consequences of failure to regulate body temperature. Thus, selection for regulation of body temperature during heat stress could increase thermotolerance. The objective was to perform a genome-wide association study (GWAS) for rectal temperature (RT) during heat stress in lactating Holstein cows and identify SNPs associated with genes that have large effects on RT. Records on afternoon RT where the temperature-humidity index was >= 78.2 were obtained from 4,447 cows sired by 220 bulls, resulting in 1,440 useable genotypes from the Illumina BovineSNP50 BeadChip with 39,759 SNP. For GWAS, 2, 3, 4, 5, and 10 adjacent SNP were averaged to identify consensus genomic regions associated with RT. The largest proportion of SNP variance (0.07 to 0.44%) was explained by markers flanking the region between 28,877,547 and 28,907,154 bp on Bos taurus autosome (BTA) 24. That region is flanked by U1 (28,822,883 to 28,823,043) and NCAD (28,992,666 to 29,241,119). In addition, the SNP at 58,500,249 bp on BTA 16 explained 0.08% and 0.11% of the SNP variance for 2- and 3-SNP analyses, respectively. That contig includes SNORA19, RFWD2 and SCARNA3. Other SNPs associated with RT were located on BTA 16 (close to CEP170 and PLD5), BTA 5 (near SLCO1C1 and PDE3A), BTA 4 (near KBTBD2 and LSM5), and BTA 26 (located in GOT1, a gene implicated in protection from cellular stress). In conclusion, there are QTL for RT in heat-stressed dairy cattle. These SNPs could prove useful in genetic selection and for identification of genes involved in physiological responses to heat stress.en_US
dc.description.sponsorshipUnited States Department of Agriculture (USDA) (2010-85122-20623)en_US
dc.description.sponsorshipUnited States Department of Agriculture (USDA) (2013-68004-20365)en_US
dc.description.sponsorshipSoutheast Dairy Inc. Milk Checkoff Programen_US
dc.identifier.citationDikmen, S. vd. (2013). "Genome-wide association mapping for identification of quantitative trait loci for rectal temperature during heat stress in holstein cattle". Plos One, 8(7).en_US
dc.identifier.issn1932-6203
dc.identifier.issue7tr_TR
dc.identifier.pubmed23935954tr_TR
dc.identifier.scopus2-s2.0-84880724183tr_TR
dc.identifier.urihttps://doi.org/10.1371/journal.pone.0069202
dc.identifier.urihttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0069202
dc.identifier.urihttp://hdl.handle.net/11452/28995
dc.identifier.volume8tr_TR
dc.identifier.wos000325211000089tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherPublic Library Scienceen_US
dc.relation.collaborationSanayitr_TR
dc.relation.collaborationYurt dışıtr_TR
dc.relation.journalPlos Oneen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectScience & technology - other topicsen_US
dc.subjectFull pedigreeen_US
dc.subjectGenetic evaluationen_US
dc.subjectDairy-cowsen_US
dc.subjectToleranceen_US
dc.subjectReproductionen_US
dc.subjectProteinsen_US
dc.subjectLengthen_US
dc.subject.emtreeContigen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeAutosomeen_US
dc.subject.emtreeCEP170 geneen_US
dc.subject.emtreeCowen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeGeneen_US
dc.subject.emtreeGenetic associationen_US
dc.subject.emtreeGenotypeen_US
dc.subject.emtreeGot1 geneen_US
dc.subject.emtreeHeat stressen_US
dc.subject.emtreeHumidityen_US
dc.subject.emtreeKBTBD2 geneen_US
dc.subject.emtreeLactationen_US
dc.subject.emtreeLSM5 geneen_US
dc.subject.emtreeNCAD geneen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreePDE3A geneen_US
dc.subject.emtreePLD5 geneen_US
dc.subject.emtreeQuantitative trait locus mappingen_US
dc.subject.emtreeRectum temperatureen_US
dc.subject.emtreeRFWD2 geneen_US
dc.subject.emtreeSCARNA3 geneen_US
dc.subject.emtreeSingle nucleotide polymorphismen_US
dc.subject.emtreeSLCO1C1 geneen_US
dc.subject.emtreeSNORA19 geneen_US
dc.subject.emtreeU1 geneen_US
dc.subject.emtreeAnimalen_US
dc.subject.emtreeBody temperatureen_US
dc.subject.emtreeCattleen_US
dc.subject.emtreeChromosome mapen_US
dc.subject.emtreeGene locusen_US
dc.subject.emtreeGeneticsen_US
dc.subject.emtreeHeat shock responseen_US
dc.subject.emtreePathophysiologyen_US
dc.subject.emtreeQuantitative trait locusen_US
dc.subject.emtreeRectumen_US
dc.subject.emtreeBody temperatureen_US
dc.subject.emtreeBovinaeen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBody temperatureen_US
dc.subject.meshCattleen_US
dc.subject.meshChromosome mappingen_US
dc.subject.meshGenetic locien_US
dc.subject.meshGenome-wide association studyen_US
dc.subject.meshHeat-shock responseen_US
dc.subject.meshPolymorphism, single nucleotideen_US
dc.subject.meshQuantitative trait locien_US
dc.subject.meshRectumen_US
dc.subject.scopusDairy Cows; Holstein-Friesian Cattle; Cattleen_US
dc.subject.wosMultidisciplinary sciencesen_US
dc.titleGenome-wide association mapping for identification of quantitative trait loci for rectal temperature during heat stress in holstein cattleen_US
dc.typeArticle
dc.wos.quartileQ1en_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Dikmen_vd_2013.pdf
Size:
250.37 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Web of Science
Scopus