Buzağı enzootik pneumonisinin tedavisinde enrofloxacin ile enrofloxacin+flunixin meglumine kombinasyonunun etkilerinin karşılaştırılması
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Date
1999-09-07
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Uludağ Üniversitesi
Abstract
Bu araştırmada enzootik pneumoni belirtileri (ateş, taşipne, öksürük ... ) gösteren 40 buzağıda (3-6 aylık) enrofloksasin ile enrofloksasin+fluniksin meglumin kombinasyonunun etkilerinin karşılaştırılması amaçlandı. Tedavi aşamasında iki farklı grup oluşturuldu; I.gruptan=20) enrofloksasin (5 mg/kg, i.m.,x 1, 5 gün), II. gruptan=20) bu tedavi ile birlikte fluniksin meglumin (2.2mg/kg, i.v., tek doz) kullanıldı. Klinik ve hematolojik muayeneler araştırmanın 1., 2., 3., 5. ve 7.günlerinde tekrar edildi. Temperaturun I.grupta 3.günden, ll.grupta ise 2.günden itibaren azaldığı (p<0.001); kalp frekansı ve solunum sayısının II.grupta I.gruba göre 2.günden itibaren daha az olduğu belirlendi. Total lökosit sayılarının her iki grupta da tedavi ile birlikte arttığı, II.gruptaki nötrofil oranının 2.günden itibaren azaldığı, ancak normal sınırlar içinde kaldıkları tespit edildi. Beş günlük tedavi sonrasında tam olarak iyileşmediği belirlenen I.gruptaki 13, II.gruptaki 4 buzağıya 2 gün süreyle enrofloksasin uygulamasına devam edildi. Sonuç olarak bu araştırma ile buzağı enzootik pneumonilerinin tedavisinde enrofloksasin ile tek doz fluniksin meglumin kombinasyonunun etkili bir şekilde kullanılabileceği ve beraberinde tedavi süresinin kısaltılabileceği kanısına varıldı.
It was aimed to compare the effects of enrofloxacin and enrofloxacin+flunixin meglumine combination in 40 calves (3-6 months) exhibiting signs (fever, tachypnea, coughing ... ) of enzootic pneumonia in this study. At the treatment stage, two different groups were designed: enrofloxacin (5mglkg, i.m., 1 x, 5 days) in 1 group (n=20) and flunixin meglumine (2.2mglkg, i. v. once) in II group (n=20) in addition to ısı group's therapy. Clinical and hematological examinations were repeated in the 1st, 2nd, 3th, 5th and 7 days of this study. It was observed that temperature reduced from 3'd day in group I and 2"d day in group II (p<0.001); heart and respiratory rates of group II were less than those of group I. It was determined that WBC count increased in each group; neutrophil rate decreased from 2" day in group II during treatment, but within normal limits. After 5 days treatment, administration of enrofloxacin was maintained for 2 days to 3 calves in group I and 4 calves in group II which were observed to be completely recovered.
It was aimed to compare the effects of enrofloxacin and enrofloxacin+flunixin meglumine combination in 40 calves (3-6 months) exhibiting signs (fever, tachypnea, coughing ... ) of enzootic pneumonia in this study. At the treatment stage, two different groups were designed: enrofloxacin (5mglkg, i.m., 1 x, 5 days) in 1 group (n=20) and flunixin meglumine (2.2mglkg, i. v. once) in II group (n=20) in addition to ısı group's therapy. Clinical and hematological examinations were repeated in the 1st, 2nd, 3th, 5th and 7 days of this study. It was observed that temperature reduced from 3'd day in group I and 2"d day in group II (p<0.001); heart and respiratory rates of group II were less than those of group I. It was determined that WBC count increased in each group; neutrophil rate decreased from 2" day in group II during treatment, but within normal limits. After 5 days treatment, administration of enrofloxacin was maintained for 2 days to 3 calves in group I and 4 calves in group II which were observed to be completely recovered.
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Keywords
Enzootik pneumoni, Buzağı, Enrotloksasin, Fluniksin meglumin, Enzootic pneumonia, Calves, Enrofloxacin, Flunixin meglumine
Citation
Yılmaz, Z. vd. (2000). ''Buzağı enzootik pneumonisi'nin tedavisinde enrofloxacin ile enrofloxacin+flunixin meglumine kombinasyonunun etkilerinin karşılaştırılması''. Uludağ Üniversitesi Veteriner Fakültesi Dergisi, 19(1-2), 29-34.