HLA class I and class II antigens in Turkish patients with chronic ordinary urticaria

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dc.contributor.buuauthorAydoğan, Kenan
dc.contributor.buuauthorKaradoğan, Serap Köran
dc.contributor.buuauthorAkdağ, İhsan Ömür
dc.contributor.buuauthorTunalı, Şükran
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Dermatoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-0193-1128tr_TR
dc.contributor.researcheridAAH-6216-2021tr_TR
dc.contributor.scopusid9739755800tr_TR
dc.contributor.scopusid9738885800tr_TR
dc.contributor.scopusid8342488100tr_TR
dc.contributor.scopusid7004191748tr_TR
dc.date.accessioned2021-10-08T07:30:26Z
dc.date.available2021-10-08T07:30:26Z
dc.date.issued2006
dc.description.abstractBackground. Chronic urticaria is a common disease with an unclear pathogenesis, which may be resistant to therapy. Recent studies have focused primarily on a possible autoimmune basis. Aim. To investigate HLA class I and II antigens in a Turkish population with chronic ordinary urticaria (COU; not physical, vasculitic or contact), and identify susceptible HLA antigens. Methods. HLA antigens were investigated in 55 patients diagnosed with COU, using a two-stage microdroplet lymphocytotoxicity test, with 104 healthy and genetically unrelated individuals evaluated as the control group. Results. HLA Bw4 and HLA DQ1 antigens were significantly higher in the study group (odds ratio (OR) = 2.93, 95% CI 1.47-5.85, P = 0.003 and OR = 7.81, 95% CI 1.96-28.50, P = 0.001, respectively) whereas HLA-A24 antigen was higher in controls (OR = 0.36, 95% CI 0.15-0.86, P = 0.03). Conclusion. We propose that HLA-Bw4 and DQ1 antigens may be responsible for susceptibility to COU while HLA-A24 may have a protective role in the Turkish population.en_US
dc.identifier.citationAydoğan, K. vd. (2006). ''HLA class I and class II antigens in Turkish patients with chronic ordinary urticaria''. Clinical and Experimental Dermatology, 31(3), 424-429.en_US
dc.identifier.endpage429tr_TR
dc.identifier.issn0307-6938
dc.identifier.issn1365-2230
dc.identifier.issue3tr_TR
dc.identifier.pubmed16681593tr_TR
dc.identifier.scopus2-s2.0-33645420708tr_TR
dc.identifier.startpage424tr_TR
dc.identifier.urihttps://doi.org/10.1111/j.1365-2230.2005.02039.x
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1111/j.1365-2230.2005.02039.x
dc.identifier.urihttp://hdl.handle.net/11452/22296
dc.identifier.volume31tr_TR
dc.identifier.wos000236242400025tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherDermatologyen_US
dc.relation.journalClinical and Experimental Dermatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDermatologyen_US
dc.subjectEdemaen_US
dc.subjectLinkageen_US
dc.subjectAssociationen_US
dc.subject.emtreeHLA DQ1 antigenen_US
dc.subject.emtreeHLA B antigenen_US
dc.subject.emtreeHLA antigen class 2en_US
dc.subject.emtreeHLA antigen class 1en_US
dc.subject.emtreeHLA antigenen_US
dc.subject.emtreeHLA A24 antigenen_US
dc.subject.meshUrticariaen_US
dc.subject.meshTurkeyen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshMaleen_US
dc.subject.meshLogistic modelsen_US
dc.subject.meshHumansen_US
dc.subject.meshHLA-DQ antigensen_US
dc.subject.meshHLA-B antigensen_US
dc.subject.meshHLA-A antigensen_US
dc.subject.meshHLA antigensen_US
dc.subject.meshFluorescent antibody techniqueen_US
dc.subject.meshFemaleen_US
dc.subject.meshDisease susceptibilityen_US
dc.subject.meshCytotoxicity tests, immunologicen_US
dc.subject.meshChronic diseaseen_US
dc.subject.meshChi-square distributionen_US
dc.subject.meshCase-control studiesen_US
dc.subject.meshAgeden_US
dc.subject.meshAdulten_US
dc.subject.scopusOmalizumab; Urticaria; Non-Sedating Histamine H1 Antagoniststr_TR
dc.subject.wosDermatologyen_US
dc.titleHLA class I and class II antigens in Turkish patients with chronic ordinary urticariaen_US
dc.typeArticle
dc.wos.quartileQ3en_US

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