Nosocomial diarrhea and Clostridium Difficile associated diarrhea in a Turkish University Hospital

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dc.contributor.authorBakker, Dennis
dc.contributor.authorKuijper, Ed J.
dc.contributor.buuauthorErgen, E. K.
dc.contributor.buuauthorAkalın, Halis
dc.contributor.buuauthorYılmaz, Emel
dc.contributor.buuauthorSınırtaş, Melda
dc.contributor.buuauthorAlver, Oktay
dc.contributor.buuauthorHeper, Yasemin
dc.contributor.buuauthorÖzakın, Cüneyt
dc.contributor.buuauthorEner, Beyza
dc.contributor.buuauthorMstık, Reşit
dc.contributor.buuauthorHelvacı, Safiye
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Enfeksiyon Hastalıkları ve Mikrobiyoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-3894-1231tr_TR
dc.contributor.orcid0000-0002-4803-8206tr_TR
dc.contributor.researcheridAAH-6506-2021tr_TR
dc.contributor.researcheridAAG-8523-2021tr_TR
dc.contributor.researcheridAAA-5241-2021tr_TR
dc.contributor.researcheridAAU-8952-2020tr_TR
dc.contributor.scopusid35078341200tr_TR
dc.contributor.scopusid57207553671tr_TR
dc.contributor.scopusid22037135100tr_TR
dc.contributor.scopusid6505818048tr_TR
dc.contributor.scopusid24070021900tr_TR
dc.contributor.scopusid56191003300tr_TR
dc.contributor.scopusid57200678942tr_TR
dc.contributor.scopusid15053025300tr_TR
dc.contributor.scopusid6602564624tr_TR
dc.contributor.scopusid6602103491tr_TR
dc.date.accessioned2022-05-27T12:28:19Z
dc.date.available2022-05-27T12:28:19Z
dc.date.issued2009-06
dc.description.abstractBackground. - Clostridium difficile (C. difficile) is a well-established cause of nosocomial diarrhea. The aim of our study was to define the incidence of nosocomial diarrhea in our hospital and to determine the role of C. difficile. Additionally, the risk factors for nosocomial diarrhea and Clostridium difficile associated diarrhea (CDAD) were investigated. Methods. - We included all patients, 18 years of age or more, who were admitted to the Uludag Teaching Hospital between October 1, 2004 and February 1, 2005, and developed diarrhea at least three days after hospital admission. A case-control study was per-formed. Results. - The total incidence of nosocomial diarrhea was 0.6 per 1,000 hospitalization-days and 5 per 1,000 patients' admissions. Previous use of chemotherapy was found to be an important predisposing factor for nosocomial diarrhea. The incidence of CDAD was 0.26 per 1,000 hospitalization-days and 2.1 per 1,000 admissions, comparable with incidence rates in Europe. CDAD was diagnosed in 43% of patients with nosocomial diarrhea. No severe cases of CDAD were diagnosed. A correlation was found between CDAD and antibiotic use before admission and during admission in univariate analysis. PCR ribotyping revealed four strains of PCR ribotype 002 and I strain of ribotype 0 12 Out of 5 C difficile strains available for extensive identification. Conclusion. - The incidence rates of nosocomial diarrhea and CDAD are not different than the usual incidence rates in Europe. C. difficile was the causative agent in 43% of patients with nosocomial diarrhea.en_US
dc.identifier.citationErgen, E. K. vd. (2009). "Nosocomial diarrhea and Clostridium Difficile associated diarrhea in a Turkish University Hospital". Medecine et Maladies Infectieuses, 39(6), 382-387.en_US
dc.identifier.endpage387tr_TR
dc.identifier.issn0399-077X
dc.identifier.issue6tr_TR
dc.identifier.pubmed19269761tr_TR
dc.identifier.scopus2-s2.0-67349184631tr_TR
dc.identifier.startpage382tr_TR
dc.identifier.urihttps://doi.org/10.1016/j.medmal.2009.02.001
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0399077X09000304
dc.identifier.urihttp://hdl.handle.net/11452/26730
dc.identifier.volume39tr_TR
dc.identifier.wos000267464100006tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherElsevier Franceen_US
dc.relation.bapT-2004-22tr_TR
dc.relation.collaborationYurt dışıtr_TR
dc.relation.journalMedecine et Maladies Infectieusesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectClostridium difficileen_US
dc.subjectClostridium difficile-associated diarrheaen_US
dc.subjectNosocomial diarrheaen_US
dc.subjectArbitrarily primed pcren_US
dc.subjectRisk-factorsen_US
dc.subjectToxin productionen_US
dc.subjectNorth-americaen_US
dc.subjectOutbreaken_US
dc.subjectDiseaseen_US
dc.subjectEpidemıologyen_US
dc.subjectDiagnosisen_US
dc.subjectGastroenteritisen_US
dc.subjectPrevalenceen_US
dc.subjectInfectious diseasesen_US
dc.subject.emtreeCiprofloxacinen_US
dc.subject.emtreeClindamycinen_US
dc.subject.emtreeErythromycinen_US
dc.subject.emtreeMetronidazoleen_US
dc.subject.emtreeMoxifloxacinen_US
dc.subject.emtreeTetracyclineen_US
dc.subject.emtreeVancomycinen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAgeden_US
dc.subject.emtreeAntibiotic sensitivityen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBacterial strainen_US
dc.subject.emtreeBacterium identificationen_US
dc.subject.emtreeCase control studyen_US
dc.subject.emtreeClinical articleen_US
dc.subject.emtreeClostridium difficileen_US
dc.subject.emtreeClostridium difficile infectionen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDisease predispositionen_US
dc.subject.emtreeFeces analysisen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeHospital admissionen_US
dc.subject.emtreeHospital infectionen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeIncidenceen_US
dc.subject.emtreeLaboratory testen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreePolymerase chain reactionen_US
dc.subject.emtreeRibotypingen_US
dc.subject.emtreeRisk factoren_US
dc.subject.emtreeTurkey (republic)en_US
dc.subject.emtreeUniversity hospitalen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshCase-control studiesen_US
dc.subject.meshClostridium difficileen_US
dc.subject.meshCross infectionen_US
dc.subject.meshDiarrheaen_US
dc.subject.meshDNA primersen_US
dc.subject.meshEnterocolitis, pseudomembranousen_US
dc.subject.meshEuropeen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIncidenceen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshPolymerase chain reactionen_US
dc.subject.meshTurkeyen_US
dc.subject.meshYoung adulten_US
dc.subject.scopusClostridium Infections; Peptoclostridium Difficile; Anti-Bacterial Agentsen_US
dc.subject.wosInfectious diseasesen_US
dc.titleNosocomial diarrhea and Clostridium Difficile associated diarrhea in a Turkish University Hospitalen_US
dc.typeArticle
dc.wos.quartileQ4en_US

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