Routine use of prophylactic antibiotics during laparoscopic cholecystectomy does not reduce the risk of surgical site infections

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dc.contributor.authorKılıçturgay, Sadık
dc.contributor.authorAktaş, Hikmet
dc.contributor.buuauthorSarkut, Pınar
dc.contributor.buuauthorÖzen, Yılmaz
dc.contributor.buuauthorKaya, Ekrem
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-9562-4195tr_TR
dc.contributor.researcheridAAG-7319-2021tr_TR
dc.contributor.scopusid55806454400tr_TR
dc.contributor.scopusid6508243334tr_TR
dc.contributor.scopusid7004568109tr_TR
dc.date.accessioned2023-01-30T12:29:23Z
dc.date.available2023-01-30T12:29:23Z
dc.date.issued2017-06
dc.descriptionBu çalışma, 22-24 Kasım 2012 tarihleri arasında İstanbul[Türkiye]’da düzenlenen 16. Annual Meeting of the European-Society-of-Surgery (ESS)’da bildiri olarak sunulmuştur.tr_TR
dc.description.abstractBackground: Laparoscopic cholecystectomy (LC) is the gold standard for the treatment of symptomatic gallbladder stones. As infections are rare in uncomplicated LC, it is widely accepted that prophylactic antibiotics need not be administered, and guidelines do not support routine antibiotic prophylaxis during elective LC. However, routine antibiotic prophylaxis for elective LC is still popular in many clinical settings. We investigated this situation in our department. Method: This randomized double-blind controlled study included 570 patients who underwent LC between March 2007 and February 2010. The exclusion criteria were antibiotic intake before surgery, steroid treatment, and the presence of pancreatitis, cholangitis, obstructive jaundice, cephalosporin allergy, or pregnancy. The patients were randomized into three groups. Group 1 (n = 193) received physiologic saline as placebo, Group 2 (n = 191) received a first-generation cephalosporin (cefazolin; 1 g), and Group 3 (n = 186) received a second-generation cephalosporin (cefuroksim aksetil; 750mg). Bile and epigastric and umbilical port tissue samples were harvested for culture. All patients were observed until the end of the fourth week after surgery. Patient age, sex, weight, American Society of Anesthesiologists (ASA) score, diabetes mellitus, smoking history, history of biliary colic in the past month, length of the hospital stay before the operation, operational findings (acute or chronic cholecystitis), operation duration, use of drainage, type of prophylaxis administered if any, culture results, surgical site infection (SSI) development, and time to SSI development along with associated treatments were evaluated. Results: There was no statistically significant difference between the groups with respect to any of the demographic and clinical features analyzed in this study. The SSI rate was 1.2% in total, and in Groups 1, 2, and 3, it was 1.5%, 1.04%, and 1.07%, respectively. There was no statistical difference regarding SSI among the groups (p = 1.00). Superficial SSI was observed in all groups, and in all patients, the site of infection was the entrance to the epigastric port through which the gallbladder had been removed. Conclusions: Surgical site infection is rare after LC, and antibiotic prophylaxis does not appear to affect the outcome significantly. Moreover, factors such as positive bile cultures, history of biliary attack, ASA score, diabetes, obesity, and smoking do not have any effect on SSI development. Thus, we conclude that antibiotic prophylaxis is not needed for elective LC.en_US
dc.description.sponsorshipEuropean Soc Surgeryen_US
dc.identifier.citationSarkut, P. vd. (2017). ''Routine use of prophylactic antibiotics during laparoscopic cholecystectomy does not reduce the risk of surgical site infections''. Surgical Infections, 18(5), 603-609.en_US
dc.identifier.endpage609tr_TR
dc.identifier.issn1096-2964
dc.identifier.issue5tr_TR
dc.identifier.pubmed28375803tr_TR
dc.identifier.scopus2-s2.0-85019694228tr_TR
dc.identifier.startpage603tr_TR
dc.identifier.urihttps://doi.org/10.1089/sur.2016.265
dc.identifier.urihttps://www.liebertpub.com/doi/10.1089/sur.2016.265
dc.identifier.uri1557-8674
dc.identifier.urihttp://hdl.handle.net/11452/30717
dc.identifier.volume18tr_TR
dc.identifier.wos000404260600012tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.indexed.wosCPCISen_US
dc.language.isoenen_US
dc.publisherMary Ann Lieberten_US
dc.relation.collaborationSanayitr_TR
dc.relation.journalSurgical Infectionsen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararasıtr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectInfectious diseasesen_US
dc.subjectSurgeryen_US
dc.subjectLaparoscopic cholecystectomyen_US
dc.subjectProphylactic antibioticsen_US
dc.subjectSurgical site infectionen_US
dc.subjectPostoperative infectionen_US
dc.subjectGallbladder perforationen_US
dc.subjectPreventionen_US
dc.subjectEfficacyen_US
dc.subjectNeeden_US
dc.subject.emtreeAntibiotic agenten_US
dc.subject.emtreeCefazolinen_US
dc.subject.emtreeCefuroxime axetilen_US
dc.subject.emtreePlaceboen_US
dc.subject.emtreeAntiinfective agenten_US
dc.subject.emtreeAcute cholecystitisen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAgeden_US
dc.subject.emtreeBacterial growthen_US
dc.subject.emtreeBacterium isolateen_US
dc.subject.emtreeBileen_US
dc.subject.emtreeBiliary colicen_US
dc.subject.emtreeCholelithiasisen_US
dc.subject.emtreeChronic cholecystitisen_US
dc.subject.emtreeConference Paperen_US
dc.subject.emtreeControlled clinical trial;en_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDiabetes mellitusen_US
dc.subject.emtreeDouble blind procedureen_US
dc.subject.emtreeDrug efficacyen_US
dc.subject.emtreeElective surgeryen_US
dc.subject.emtreeEnterococcus faecalisen_US
dc.subject.emtreeEnterococcus faeciumen_US
dc.subject.emtreeEscherichia colien_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeGram negative bacteriumen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeHuman tissueen_US
dc.subject.emtreeInfection preventionen_US
dc.subject.emtreeInfection risken_US
dc.subject.emtreeLaparoscopic cholecystectomyen_US
dc.subject.emtreeLength of stayen_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMedical historyen_US
dc.subject.emtreeObesityen_US
dc.subject.emtreeOperation durationen_US
dc.subject.emtreePostoperative complicationen_US
dc.subject.emtreePreoperative perioden_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeProphylaxisen_US
dc.subject.emtreeRandomized controlled trialen_US
dc.subject.emtreeRare diseaseen_US
dc.subject.emtreeRisk assessmenten_US
dc.subject.emtreeRisk factoren_US
dc.subject.emtreeRisk reductionen_US
dc.subject.emtreeScoring systemen_US
dc.subject.emtreeSmokingen_US
dc.subject.emtreeStaphylococcus epidermidisen_US
dc.subject.emtreeStaphylococcus haemolyticusen_US
dc.subject.emtreeSurgical drainageen_US
dc.subject.emtreeSurgical infectionen_US
dc.subject.emtreeTissue cultureen_US
dc.subject.emtreeVery elderlyen_US
dc.subject.emtreeAdolescenten_US
dc.subject.emtreeAntibiotic prophylaxisen_US
dc.subject.emtreeBacteriumen_US
dc.subject.emtreeIsolation and purificationen_US
dc.subject.emtreeLaparoscopic cholecystectomyen_US
dc.subject.emtreeMicrobiologyen_US
dc.subject.emtreeMiddle ageden_US
dc.subject.emtreeStatistics and numerical dataen_US
dc.subject.emtreeSurgical wound infectionen_US
dc.subject.emtreeYoung adulten_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 and overen_US
dc.subject.meshAnti-bacterial agentsen_US
dc.subject.meshAntibiotic prophylaxisen_US
dc.subject.meshBacteriaen_US
dc.subject.meshCholecystectomyen_US
dc.subject.meshLaparoscopicen_US
dc.subject.meshDouble-blind methoden_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshSurgical wound infectionen_US
dc.subject.meshYoung adulten_US
dc.subject.scopusAntibiotic Prophylaxis; Surgical Infection; Anti-Bacterial Agentsen_US
dc.subject.wosInfectious diseasesen_US
dc.subject.wosSurgeryen_US
dc.titleRoutine use of prophylactic antibiotics during laparoscopic cholecystectomy does not reduce the risk of surgical site infectionsen_US
dc.typeArticle
dc.typeProceedings Paper
dc.wos.quartileQ4 (Infectious diseases)en_US
dc.wos.quartileQ3 (Surgery)en_US

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