Ischemia and reoxygenation induced amino acid release release and tissue damage in the slices of rat corpus striatum

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dc.contributor.buuauthorBüyükuysal, Rıfat Levent
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Farmakoloji Anabilim Dalı.tr_TR
dc.contributor.researcheridAAH-1657-2021tr_TR
dc.contributor.scopusid6602686612tr_TR
dc.date.accessioned2022-04-28T10:50:37Z
dc.date.available2022-04-28T10:50:37Z
dc.date.issued2004-08
dc.description.abstractIschemic incubation significantly increased amino acid release from rat striatal slices. Reoxygenation (REO) of the ischemic slices, however, enhanced only taurine and citrulline levels in the medium. Ischemia-induced increases in glutamate, taurine and GABA outputs were accompanied with a similar amount of decline in their tissue levels. Tissue final aspartic acid level, however, was doubled by ischemia. Lactate dehydrogenase (LDH) leakage was not altered by ischemia, but enhanced during REO. Presence of tetrodotoxine (TTX) during ischemic period caused significant decline in ischemia-induced glutamate output, but not altered REO-induced LDH leakage. Although omission of extracellular calcium ions from the medium during ischemic period protected the slices against REO-induced LDH leakage, this treatment failed to alter ischemia-induced glutamate and GABA outputs. The release of other amino acids, however, declined 50% in calcium-free medium. Blockade of the glutamate uptake transporter by L-trans-PDC, on the other hand, doubled ischemia induced glutamate and aspartic acid outputs. These results indicate that more than one mechanisms probably support the ischemia-evoked accumulation of glutamate and other amino acids in the extracellular space. Although LDH leakage enhanced during REO, processes involved in this increment were found to be dependent on extracellular calcium ions during ischemia but not REO period.en_US
dc.identifier.citationBüyükuysal, R. L. (2004). “Ischemia and reoxygenation induced amino acid release release and tissue damage in the slices of rat corpus striatum”. Amino Acids, 27(1), 57-67.en_US
dc.identifier.endpage67tr_TR
dc.identifier.issn0939-4451
dc.identifier.issue1tr_TR
dc.identifier.pubmed15309572tr_TR
dc.identifier.scopus2-s2.0-4444279853tr_TR
dc.identifier.startpage57tr_TR
dc.identifier.urihttps://doi.org/10.1007/s00726-004-0073-9
dc.identifier.urihttps://link.springer.com/article/10.1007/s00726-004-0073-9
dc.identifier.urihttp://hdl.handle.net/11452/26234
dc.identifier.volume27tr_TR
dc.identifier.wos000223266300007tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.journalAmino Acidsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiochemistry and molecular biologyen_US
dc.subjectIschemiaen_US
dc.subjectReoxygenationen_US
dc.subjectGlutamate releaseen_US
dc.subjectAmino acidsen_US
dc.subjectLDHen_US
dc.subjectNitric-oxide synthaseen_US
dc.subjectOxygen-glucose deprivationen_US
dc.subjectInduced glutamate effluxen_US
dc.subjectIn-vitro ischemiaen_US
dc.subjectHippocampal slicesen_US
dc.subjectCerebral-cortexen_US
dc.subjectBrain-slicesen_US
dc.subjectCerebrocortical slicesen_US
dc.subjectAnoxic depolarizationen_US
dc.subjectNeuronal injuryen_US
dc.subject.emtreeAmino acid transporten_US
dc.subject.emtreeAnimal modelen_US
dc.subject.emtreeAnimal tissueen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBrain ischemiaen_US
dc.subject.emtreeBrain tissueen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeCorpus striatumen_US
dc.subject.emtreeExtracellular calciumen_US
dc.subject.emtreeExtracellular spaceen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeRaten_US
dc.subject.emtreeReoxygenationen_US
dc.subject.emtreeTissue injuryen_US
dc.subject.emtree4 aminobutyric aciden_US
dc.subject.emtreeAmino aciden_US
dc.subject.emtreeAspartic aciden_US
dc.subject.emtreeCitrullineen_US
dc.subject.emtreeGlutamic aciden_US
dc.subject.emtreeLactate dehydrogenaseen_US
dc.subject.emtreePyrrolidine derivativeen_US
dc.subject.emtreeTaurineen_US
dc.subject.emtreeTetrodotoxinen_US
dc.subject.meshAmino acidsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnoxiaen_US
dc.subject.meshAspartic aciden_US
dc.subject.meshBrainen_US
dc.subject.meshCalciumen_US
dc.subject.meshCitrullineen_US
dc.subject.meshCorpus striatumen_US
dc.subject.meshFemaleen_US
dc.subject.meshGamma-aminobutyric aciden_US
dc.subject.meshGlutamic aciden_US
dc.subject.meshIonsen_US
dc.subject.meshIschemiaen_US
dc.subject.meshL-lactate dehydrogenaseen_US
dc.subject.meshMaleen_US
dc.subject.meshOxygenen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, wistaren_US
dc.subject.meshReperfusion injuryen_US
dc.subject.meshTaurineen_US
dc.subject.meshTetrodotoxinen_US
dc.subject.meshTime factorsen_US
dc.subject.scopusDopamine; Catecholamines; 4-Hydroxyphenethylene Glycolen_US
dc.subject.wosBiochemistry and molecular biologyen_US
dc.titleIschemia and reoxygenation induced amino acid release release and tissue damage in the slices of rat corpus striatumen_US
dc.typeArticle
dc.wos.quartileQ3en_US

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