CDP-choline modulates matrix metalloproteinases in rat sciatic injury

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dc.contributor.buuauthorGündoğdu, Elif Başaran
dc.contributor.buuauthorBekar, Ahmet
dc.contributor.buuauthorTürkyılmaz, Mesut
dc.contributor.buuauthorGümüş, Abdullah
dc.contributor.buuauthorKafa, İlker Mustafa
dc.contributor.buuauthorCansev, Mehmet
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Nöroşirürji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Eczacılık Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Anatomi Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-9140-4195tr_TR
dc.contributor.orcid0000-0001-8309-0934tr_TR
dc.contributor.orcid0000-0003-2918-5064tr_TR
dc.contributor.researcheridAAG-7125-2021tr_TR
dc.contributor.researcheridM-9071-2019tr_TR
dc.contributor.scopusid57016583400tr_TR
dc.contributor.scopusid6603677218tr_TR
dc.contributor.scopusid56320252500tr_TR
dc.contributor.scopusid56473463900tr_TR
dc.contributor.scopusid8450193200tr_TR
dc.contributor.scopusid8872816100tr_TR
dc.date.accessioned2023-03-07T06:54:30Z
dc.date.available2023-03-07T06:54:30Z
dc.date.issued2015-10-01
dc.description.abstractBackground: CDP-choline (cytidine-5'-diphosphocholine) improves functional recovery, promotes nerve regeneration, and decreases perineural scarring in rat peripheral nerve injury. The aim of the present study was to investigate the mechanism of action of CDPcholine with regard to matrix metalloproteinase (MMP) activity in the rat-transected sciatic nerve injury model. Materials and methods: Male Wistar rats were randomized into Sham, Saline, and CDPcholine groups. Rats in Sham group received Sham surgery, whereas rats in Saline and CDP-choline groups underwent right sciatic nerve transection followed by immediate primary saturation and injected intraperitoneally with 0.9% NaCl (1 mL/kg) and CDP-choline (600 mg/kg), respectively. Sciatic nerve samples were obtained 1, 3, and 7 d after the surgery and analyzed for levels and activities of MMP-2 and MMP-9, levels of tissue inhibitor of metalloproteinases-1 (TIMP-1) and TIMP-3, and axonal regeneration. Results: CDP-choline treatment decreased the levels and activities of MMP-2 and MMP-9, whereas increasing levels of TIMP-1 and TIMP-3 significantly on the third and seventh day after injury compared to Saline group. In addition, CDP-choline administration resulted in new axon formation and formation and advancement of myelination on newly formed islets (compartments) of axonal regrowth. Conclusions: Our data show, for the first time, that CDP-choline modulates MMP activity and promotes the expression of TIMPs to stimulate axonal regeneration. These data help to explain one mechanism by which CDP-choline provides neuroprotection in peripheral nerve injury.en_US
dc.identifier.citationGündoğdu, E. B. vd. (2016). "CDP-choline modulates matrix metalloproteinases in rat sciatic injury". Journal of Surgical Research, 200(2), 655-663.en_US
dc.identifier.endpage663tr_TR
dc.identifier.issn0022-4804
dc.identifier.issn1095-8673
dc.identifier.issue2tr_TR
dc.identifier.pubmed26521098tr_TR
dc.identifier.scopus2-s2.0-84982268812tr_TR
dc.identifier.startpage655tr_TR
dc.identifier.urihttps://doi.org/10.1016/j.jss.2015.10.003
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S002248041500949X
dc.identifier.urihttp://hdl.handle.net/11452/31386
dc.identifier.volume200tr_TR
dc.identifier.wos000366841500030tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.bapT/U 2012-9tr_TR
dc.relation.journalJournal of Surgical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSurgeryen_US
dc.subjectCDP-cholineen_US
dc.subjectSciatic nerve injuryen_US
dc.subjectMatrix metalloproteinaseen_US
dc.subjectTissue inhibitors of metalloproteinasesen_US
dc.subjectAxonal regenerationen_US
dc.subjectNeuroprotectionen_US
dc.subjectPeripheral-nerve surgeryen_US
dc.subjectFunctional recoveryen_US
dc.subjectExtracellular-matrixen_US
dc.subjectRegenerationen_US
dc.subjectCytidineen_US
dc.subjectModelen_US
dc.subjectMetabolitesen_US
dc.subjectExpressionen_US
dc.subjectSystemen_US
dc.subjectInvolvementen_US
dc.subject.emtreeCiticolineen_US
dc.subject.emtreeGelatinase Aen_US
dc.subject.emtreeGelatinase Ben_US
dc.subject.emtreeMatrix metalloproteinaseen_US
dc.subject.emtreeScleroproteinen_US
dc.subject.emtreeSodium chlorideen_US
dc.subject.emtreeTissue inhibitor of metalloproteinase 1en_US
dc.subject.emtreeTissue inhibitor of metalloproteinase 3en_US
dc.subject.emtreeBiological markeren_US
dc.subject.emtreeCiticolineen_US
dc.subject.emtreeGelatinase Aen_US
dc.subject.emtreeGelatinase Ben_US
dc.subject.emtreeMmp2 protein, raten_US
dc.subject.emtreeMmp9 protein, raten_US
dc.subject.emtreeNeuroprotective agenten_US
dc.subject.emtreeTissue inhibitor of metalloproteinase 1en_US
dc.subject.emtreeTissue inhibitor of metalloproteinase 3en_US
dc.subject.emtreeTissue inhibitor of metalloproteinase-1 protein, raten_US
dc.subject.emtreeAnimal cellen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeAnimal modelen_US
dc.subject.emtreeAnimal tissueen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeCell densityen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDown regulationen_US
dc.subject.emtreeDrug mechanismen_US
dc.subject.emtreeEnzyme activityen_US
dc.subject.emtreeExperimental sciatic nerve injuryen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMyelinationen_US
dc.subject.emtreeNerve transectionen_US
dc.subject.emtreeNervous tissueen_US
dc.subject.emtreeNeurite outgrowthen_US
dc.subject.emtreeNeuroprotectionen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreePerineuriumen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeProtein expression levelen_US
dc.subject.emtreeRaten_US
dc.subject.emtreeUpregulationen_US
dc.subject.emtreeZymographyen_US
dc.subject.emtreeAnimalen_US
dc.subject.emtreeDrug effectsen_US
dc.subject.emtreeEnzymologyen_US
dc.subject.emtreeEvaluation studyen_US
dc.subject.emtreeInjuriesen_US
dc.subject.emtreeIntraperitoneal drug administrationen_US
dc.subject.emtreeMetabolismen_US
dc.subject.emtreeNerve regenerationen_US
dc.subject.emtreePeripheral nerve injuriesen_US
dc.subject.emtreePhysiologyen_US
dc.subject.emtreeRandomizationen_US
dc.subject.emtreeSciatic nerveen_US
dc.subject.emtreeWestern blottingen_US
dc.subject.emtreeWistar raten_US
dc.subject.meshAnimalsen_US
dc.subject.meshBiomarkersen_US
dc.subject.meshBlotting, westernen_US
dc.subject.meshCytidine diphosphate cholineen_US
dc.subject.meshInjections, intraperitonealen_US
dc.subject.meshMaleen_US
dc.subject.meshMatrix metalloproteinase 2en_US
dc.subject.meshMatrix metalloproteinase 9en_US
dc.subject.meshNerve regenerationen_US
dc.subject.meshNeuroprotective agentsen_US
dc.subject.meshPeripheral nerve injuriesen_US
dc.subject.meshRandom allocationen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, wistaren_US
dc.subject.meshSciatic nerveen_US
dc.subject.meshTissue inhibitor of metalloproteinase-1en_US
dc.subject.meshTissue inhibitor of metalloproteinase-3en_US
dc.subject.scopusCiticoline; Brain Ischemia; Glycerylphosphorylcholineen_US
dc.subject.wosSurgeryen_US
dc.titleCDP-choline modulates matrix metalloproteinases in rat sciatic injuryen_US
dc.typeArticle
dc.wos.quartileQ2en_US

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