The effects of Tarantula cubensis venom on open wound healing in rats

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dc.contributor.buuauthorSatar, Nihal Yaşar Gül
dc.contributor.buuauthorCangül, İ. Taci
dc.contributor.buuauthorTopal, Ayşe
dc.contributor.buuauthorKurt, H.
dc.contributor.buuauthorİpek, Volkan
dc.contributor.buuauthorÖnel, G. İ.
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Cerrahi Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Veteriner Fakültesi.tr_TR
dc.contributor.orcid0000-0003-0537-2113tr_TR
dc.contributor.orcid0000-0001-5874-7797tr_TR
dc.contributor.researcheridAAB-4360-2021tr_TR
dc.contributor.scopusid55695699600tr_TR
dc.contributor.scopusid6602486125tr_TR
dc.contributor.scopusid56357211200tr_TR
dc.contributor.scopusid56514876900tr_TR
dc.contributor.scopusid57201970309tr_TR
dc.contributor.scopusid57193700584tr_TR
dc.date.accessioned2022-12-21T13:08:26Z
dc.date.available2022-12-21T13:08:26Z
dc.date.issued2017
dc.description.abstractObjective: The aim of this study was to evaluate the clinical and histopathological effects of two different dosages of alcohol extract of Tarantula cubensis (Theranekron) on open wounds. Method: A total of 24 Sprague-Dawley rats were randomly divided into Tarantula cubensis extract (TCE1, n=8) 1/10 diluted, TCE (TCE2, n=8), and (3) vehicle-control (0.2 ml of 96 % ethanol, n=8) groups. Experimental full-thickness 1 x 1cm wounds were created on dorsum skin. TCE or vehicle were given systemically by subcutaneous injections on postoperative days 1 and 4. Wound planimetry and procurement of biopsies was performed on days 4, 8, 12 and 16. Results: The mean non-epithelialised wound area in the vehiclecontrol group was significantly larger than in the TCE1 group on days 4, 8, 12 and 16, and in the TCE2 group on days 8, 12 and 16 (p < 0.05). The mean percentage of wound contraction was significantly higher in the TCE1 and TCE2 groups than in the vehicle control group on days 8, 12 and 16 (p < 0.05). Histopathologically, wound healing was characterised by a significant decrease in the neutrophil counts and a significant increase in neovascularisation; neither were effected by TCE. Conclusion: Our results suggest that alcohol extract of Tarantula cubensis accelerates epithelialisation and, thus, has beneficial effects on open wound healing in rats. Declaration of interest: No member of the authorship team has a conflict of interest to declare.en_US
dc.identifier.citationSatar, N. Y. G. vd. (2017). ''The effects of Tarantula cubensis venom on open wound healing in rats''. Journal of Wound Care, 26(2), 66-71.en_US
dc.identifier.endpage71tr_TR
dc.identifier.issn0969-0700
dc.identifier.issue2tr_TR
dc.identifier.pubmed28182522tr_TR
dc.identifier.scopus2-s2.0-85015893410tr_TR
dc.identifier.startpage66tr_TR
dc.identifier.urihttps://doi.org/10.12968/jowc.2017.26.2.66
dc.identifier.urihttps://www.magonlinelibrary.com/doi/abs/10.12968/jowc.2017.26.2.66
dc.identifier.uri2062-2916
dc.identifier.urihttp://hdl.handle.net/11452/30016
dc.identifier.volume26tr_TR
dc.identifier.wos000395651200004tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherMa Healthcareen_US
dc.relation.journalJournal of Wound Careen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDermatologyen_US
dc.subjectExtracten_US
dc.subjectRaten_US
dc.subjectSkinen_US
dc.subjectTarantula cubensisen_US
dc.subjectWound healingen_US
dc.subjectTripeptide-copper complexen_US
dc.subjectHistological-evaluationen_US
dc.subjectEfficacyen_US
dc.subject.emtreeSpider venonen_US
dc.subject.emtreeAnimalen_US
dc.subject.emtreeDrug effectsen_US
dc.subject.emtreeEpithelizationen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreePathologyen_US
dc.subject.emtreeRandomizationen_US
dc.subject.emtreeRaten_US
dc.subject.emtreeSkinen_US
dc.subject.emtreeSprague dawley raten_US
dc.subject.emtreeWound healingen_US
dc.subject.emtreeWounds and injuriesen_US
dc.subject.meshAnimalsen_US
dc.subject.meshMaleen_US
dc.subject.meshRandom allocationen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, sprague-dawleyen_US
dc.subject.meshRe-epithelializationen_US
dc.subject.meshSkinen_US
dc.subject.meshSpider venomsen_US
dc.subject.meshWound healingen_US
dc.subject.meshWounds and injuriesen_US
dc.subject.scopusRabbit; Theraphosidae; Achilles Tendonen_US
dc.subject.wosDermatologyen_US
dc.titleThe effects of Tarantula cubensis venom on open wound healing in ratsen_US
dc.typeArticle
dc.wos.quartileQ3en_US

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