Hyperglycemia induced by intracerebroventricular choline: Involvement of the sympatho-adrenal system
dc.contributor.author | Taga, Yavuz | |
dc.contributor.buuauthor | Gürun, Mine Sibel | |
dc.contributor.buuauthor | Özarda, Yeşim | |
dc.contributor.buuauthor | Ulus, İsmail Hakkı | |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Farmakoloji ve Klinik Farmakoloji Anabilim Dalı. | tr_TR |
dc.contributor.researcherid | AAL-8873-2021 | tr_TR |
dc.contributor.researcherid | D-5340-2015 | tr_TR |
dc.contributor.researcherid | AAG-8716-2019 | tr_TR |
dc.contributor.scopusid | 55664349700 | tr_TR |
dc.contributor.scopusid | 35741320500 | tr_TR |
dc.contributor.scopusid | 7004271086 | tr_TR |
dc.date.accessioned | 2021-12-08T07:17:51Z | |
dc.date.available | 2021-12-08T07:17:51Z | |
dc.date.issued | 2002-03-08 | |
dc.description.abstract | Intracerebroventricular (i.c.v.) injection of choline (75-300 mug) produced a dose-dependent increase in blood glucose levels. Pretreatment with the nicotinic acetylcholine receptor antagonist, mecamylamine (50 mug, i.c.v.) blocked the hyperglycemia induced by choline (150 mug, i.c.v.), but the response was not affected by pre-treatment with the muscarinic acetylcholine receptor antagonist, atropine (10 mug, i.c.v.). Pre-treatment with the neuronal choline uptake inhibitor, hemicholinium-3 (20 mug, i.c.v.), attenuated the hyperglycemia induced by choline. The hyperglycemic response to choline was associated increased plasma levels of adrenaline and noradrenaline. The hyperglycemia elicited by choline was greatly attenuated by bilateral adrenalectomy, and entirely blocked by either surgical transection of the splanchnic nerves or by pre-treatment with the a-adrenoceptor antagonist, phentolamine. These data show that choline, a precursor of acetylcholine, increases blood glucose and this effect is mediated by central nicotinic acetylcholine receptor activation. An increase in sympatho-adrenal activity appears to be involved in the hyperglycemic effect of choline. | en_US |
dc.identifier.citation | Gürun, M. S. vd. (2002). "Hyperglycemia induced by intracerebroventricular choline: Involvement of the sympatho-adrenal system". European Journal of Pharmacology, 438(3), 197-205. | en_US |
dc.identifier.endpage | 3 | tr_TR |
dc.identifier.issn | 0014-2999 | |
dc.identifier.issue | 205 | tr_TR |
dc.identifier.pubmed | 11909612 | tr_TR |
dc.identifier.scopus | 2-s2.0-0037040425 | tr_TR |
dc.identifier.startpage | 438 | tr_TR |
dc.identifier.uri | https://doi.org/10.1016/S0014-2999(02)01312-2 | |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0014299902013122 | |
dc.identifier.uri | http://hdl.handle.net/11452/23071 | |
dc.identifier.volume | 197 | tr_TR |
dc.identifier.wos | 000174893500011 | tr_TR |
dc.indexed.pubmed | Pubmed | en_US |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.collaboration | Yurt içi | tr_TR |
dc.relation.journal | European Journal of Pharmacology | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Choline | en_US |
dc.subject | Cholinergic activity | en_US |
dc.subject | Glucoregulation | en_US |
dc.subject | Hyperglycemia | en_US |
dc.subject | Rat | en_US |
dc.subject | Sympatho-adrenal activity | en_US |
dc.subject | Nervous-system | en_US |
dc.subject | Hippocampal acetylcholine-releaser | en_US |
dc.subject | Rat corpus striatum | en_US |
dc.subject | Conscious ratsreverses hypotension | en_US |
dc.subject | Tyrosine-hydroxylase | en_US |
dc.subject | Alzheimers-disease | en_US |
dc.subject | Glucose injections | en_US |
dc.subject | Induced decrease | en_US |
dc.subject | Cdp-choline | en_US |
dc.subject | Pharmacology & pharmacy | en_US |
dc.subject.emtree | Adrenalin | en_US |
dc.subject.emtree | Noradrenalin blood level | en_US |
dc.subject.emtree | Hemicholinium 3 | en_US |
dc.subject.emtree | Propranolol | en_US |
dc.subject.emtree | Glucose blood level | en_US |
dc.subject.emtree | Atropine | en_US |
dc.subject.emtree | Choline | en_US |
dc.subject.emtree | Mecamylamine | en_US |
dc.subject.emtree | Noradrenalin | en_US |
dc.subject.emtree | Carbachol glucose phentolamine | en_US |
dc.subject.emtree | Adrenalectomy | en_US |
dc.subject.emtree | Adrenalin blood level | en_US |
dc.subject.emtree | Adrenergic system | en_US |
dc.subject.emtree | Animal model | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Controlled study | en_US |
dc.subject.emtree | Dose response | en_US |
dc.subject.emtree | Drug effect | en_US |
dc.subject.emtree | Drug efficacy | en_US |
dc.subject.emtree | Hyperglycemia | en_US |
dc.subject.emtree | Splanchnic nerve | en_US |
dc.subject.emtree | Nerve transection | en_US |
dc.subject.emtree | Male | en_US |
dc.subject.emtree | Nonhuman | en_US |
dc.subject.emtree | Priority journal | en_US |
dc.subject.emtree | Rat | en_US |
dc.subject.mesh | Adrenalectomy | en_US |
dc.subject.mesh | Adrenal glands | en_US |
dc.subject.mesh | Blood glucose | en_US |
dc.subject.mesh | Dose-response relationship, drug | en_US |
dc.subject.mesh | Sympathetic nervous system | en_US |
dc.subject.mesh | Cholinergic agents | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Time factors | en_US |
dc.subject.mesh | Atropine | en_US |
dc.subject.mesh | Nicotinic antagonists | en_US |
dc.subject.mesh | Choline | en_US |
dc.subject.mesh | Epinephrine | en_US |
dc.subject.mesh | Hemicholinium 3 | en_US |
dc.subject.mesh | Hyperglycemia | en_US |
dc.subject.mesh | Injections, intraventricular | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Mecamylamine | en_US |
dc.subject.mesh | Norepinephrine | en_US |
dc.subject.mesh | Phentolamine | en_US |
dc.subject.mesh | Propranolol | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, wistar | en_US |
dc.subject.scopus | Citicoline; Neuroprotective Agents; Glycerylphosphorylcholine | en_US |
dc.subject.wos | Pharmacology & pharmacy | en_US |
dc.title | Hyperglycemia induced by intracerebroventricular choline: Involvement of the sympatho-adrenal system | en_US |
dc.type | Article | |
dc.wos.quartile | Q2 | en_US |
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