The effect of melatonin on lipid peroxidation during radiotherapy in female rats

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dc.contributor.authorKaya, Hakan
dc.contributor.authorDelibaş, Namik
dc.contributor.authorSerteser, Mustafa
dc.contributor.authorOzkaya, Okan
dc.contributor.buuauthorUlukaya, Engin
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.tr_TR
dc.contributor.researcheridK-5792-2018tr_TR
dc.date.accessioned2021-06-28T07:35:19Z
dc.date.available2021-06-28T07:35:19Z
dc.date.issued1999
dc.description.abstractBackground: Because radiotherapy is one of the causes of primary or secondary ovarian failure, protection of ovarian functions in the patients receiving total body or pelvic radiotherapy is of importance. In this study, we investigated the role of melatonin in the oxidative damage in both whole body and ovaries, which is caused by radiotherapy. Materials and Methods: Eighteen female rats were divided into 3 groups, each of which consisted of 6 rats. First group was control group receiving no treatment, second group received total body radiotherapy (RT) by 2 x 360 cGy only and third group received radiotherapy plus melatonin. Malondialdehyde (MDA) levels in both blood and ovarian tissue were detected as the indicator of free radical (FR) damage. Levels of erythrocyte superoxide dismutase (SOD) and glutathion peroxidase (GPX) in blood were measured as the indicators of antioxidant level. Results: Radiotherapy caused a significant increase in the levels of MDA in blood and ovarian tissue (p < 0.001). However, MDA levels decreased in the radiotherapy plus melatonin group (p < 0.05). SOD and GPX levels decreased insignificantly in the radiotherapy only group while they increased in the radiotherapy plus melatonin group significantly (p < 0.01 and p < 0.05, respectively). Conclusion: Melatonin, in rats, reduced the level of MDA, which is elevated by radiotherapy and increased the levels of SOD and GPX, which are involved in the antioxidant system.en_US
dc.identifier.citationKaya, H. vd. (1999). "The effect of melatonin on lipid peroxidation during radiotherapy in female rats". Strahlentherapie und Onkologie, 175(6), 285-288.en_US
dc.identifier.endpage288tr_TR
dc.identifier.issn0179-7158
dc.identifier.issue6tr_TR
dc.identifier.pubmed10392170tr_TR
dc.identifier.scopus2-s2.0-0033002666tr_TR
dc.identifier.startpage285tr_TR
dc.identifier.urihttps://doi.org/10.1007/BF02743581
dc.identifier.urihttps://link.springer.com/article/10.1007/BF02743581
dc.identifier.urihttp://hdl.handle.net/11452/20862
dc.identifier.volume175tr_TR
dc.identifier.wos000080891300007tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherUrban & Vogelen_US
dc.relation.collaborationYurt içitr_TR
dc.relation.journalStrahlentherapie und Onkologieen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFree radicalsen_US
dc.subjectMelatoninen_US
dc.subjectTBI raten_US
dc.subjectInterleukin-2 plus melatoninen_US
dc.subjectSubstancesen_US
dc.subjectRadicalsen_US
dc.subjectBiologyen_US
dc.subjectCanceren_US
dc.subjectDamageen_US
dc.subject.wosOncologyen_US
dc.subject.wosRadiologyen_US
dc.subject.wosNuclear medicine & medical imagingen_US
dc.titleThe effect of melatonin on lipid peroxidation during radiotherapy in female ratsen_US
dc.typeArticle

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