Folic acid-conjugated cationic Ag2S quantum dots for optical imaging and selective doxorubicin delivery to HeLa cells

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dc.contributor.authorDuman, Fatma Demir
dc.contributor.authorKhodadust, Rouhullah
dc.contributor.authorUlukaya, Engin
dc.contributor.authorAcar, Havva Yağcı
dc.contributor.buuauthorErkısa, Merve
dc.contributor.buuauthorArı, Ferda
dc.contributor.departmentUludağ Üniversitesi/Fen-Edebiyet Fakültesi/Biyoloji Bölümü.tr_TR
dc.contributor.orcid0000-0002-3127-742Xtr_TR
dc.contributor.orcid0000-0002-6729-7908tr_TR
dc.contributor.researcheridAAM-1001-2020tr_TR
dc.contributor.researcheridAAG-7012-2021tr_TR
dc.contributor.scopusid57126208900tr_TR
dc.contributor.scopusid24376085300tr_TR
dc.date.accessioned2022-12-22T08:49:01Z
dc.date.available2022-12-22T08:49:01Z
dc.date.issued2017-10
dc.description.abstractWe aim to develop folic acid ( FA)-conjugated cationic Ag2S near-infrared quantum dots (NIRQDs) for the delivery of doxorubicin (DOX) selectively to folate receptor (FR)-positive cancer cells to achieve enhanced drug efficacy and optical tracking in the NIR region. Materials & methods: Cationic Ag2S NIRQDs were decorated with FA using a PEG bridge and loaded with DOX. In vitro studies were performed on FR-positive human cervical carcinoma cells and FR-negative A549 cells. Results: Significantly higher uptake of DOX by human cervical carcinoma cells cells and a greater therapeutic effect along with a strong intracellular optical signal were obtained with DOX-loaded FA-conjugated Ag2S NIRQDs. Conclusion: These Ag2S NIRQDs are promising theranostic nanoparticles for receptor-mediated delivery of DOX with enhanced drug efficacy combined with optical imaging.en_US
dc.identifier.citationDuman, F. D. vd. (2017). ''Folic acid-conjugated cationic Ag2S quantum dots for optical imaging and selective doxorubicin delivery to HeLa cells''. Nanomedicine, 12(19), 2319-2333.en_US
dc.identifier.endpage2333tr_TR
dc.identifier.issn1743-5889
dc.identifier.issue19tr_TR
dc.identifier.pubmed28875744tr_TR
dc.identifier.scopus2-s2.0-85030166267tr_TR
dc.identifier.startpage2319tr_TR
dc.identifier.urihttps://doi.org/10.2217/nnm-2017-0180
dc.identifier.urihttps://www.futuremedicine.com/doi/10.2217/nnm-2017-0180
dc.identifier.uri1748-6963
dc.identifier.urihttp://hdl.handle.net/11452/30045
dc.identifier.volume12tr_TR
dc.identifier.wos000411843400004
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherFuture Medicineen_US
dc.relation.bapBUAP(F)-2014/3tr_TR
dc.relation.collaborationYurt içitr_TR
dc.relation.journalNanomedicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.relation.tubitak113Z164tr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiotechnology & applied microbiologyen_US
dc.subjectScience & technology - other topicsen_US
dc.subjectAg2S quantum dotsen_US
dc.subjectCancer therapyen_US
dc.subjectDoxorubicinen_US
dc.subjectNear-infrared imaging;en_US
dc.subjectTargetingen_US
dc.subjectDrug-deliveryhigen_US
dc.subjectHly luminescenten_US
dc.subjectCytotoxicityen_US
dc.subjectFolateen_US
dc.subjectCardiotoxicityen_US
dc.subjectNanoparticlesen_US
dc.subjectApoptosisen_US
dc.subjectAssayen_US
dc.subjectToolen_US
dc.subject.emtreeDoxorubicinen_US
dc.subject.emtreeFolic aciden_US
dc.subject.emtreeQuantum doten_US
dc.subject.emtreeSilver sulfide quantum doten_US
dc.subject.emtreeSulfideen_US
dc.subject.emtreeUnclassified drugen_US
dc.subject.emtreeAntineoplastic agenten_US
dc.subject.emtreeDoxorubicinen_US
dc.subject.emtreeDrug carrieren_US
dc.subject.emtreeFluorescent dyeen_US
dc.subject.emtreeFolic aciden_US
dc.subject.emtreeMacrogolen_US
dc.subject.emtreeNanoconjugateen_US
dc.subject.emtreeQuantum doten_US
dc.subject.emtreeSilver derivativeen_US
dc.subject.emtreeSilver sulfideen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeCervical cancer cell lineen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeCytotoxicityen_US
dc.subject.emtreeDrug delivery systemen_US
dc.subject.emtreeDrug efficacyen_US
dc.subject.emtreeDrug mechanismen_US
dc.subject.emtreeDrug synthesisen_US
dc.subject.emtreeDrug uptakeen_US
dc.subject.emtreeFluorescence imagingen_US
dc.subject.emtreeHeLa cell lineen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeHuman cellen_US
dc.subject.emtreeIn vitro studyen_US
dc.subject.emtreeIntracellular signalingen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeQuantum yielden_US
dc.subject.emtreeA-549 cell lineen_US
dc.subject.emtreeApoptosisen_US
dc.subject.emtreeCell culture techniqueen_US
dc.subject.emtreeCell survivalen_US
dc.subject.emtreeChemistryen_US
dc.subject.emtreeDrug releaseen_US
dc.subject.emtreeFluorescence imagingen_US
dc.subject.emtreeParticle sizeen_US
dc.subject.emtreeProceduresen_US
dc.subject.emtreeSurface propertyen_US
dc.subject.emtreeHeLa cell lineen_US
dc.subject.meshA549 cellsen_US
dc.subject.meshAntineoplastic agentsen_US
dc.subject.meshApoptosisen_US
dc.subject.meshCell culture techniquesen_US
dc.subject.meshCell survivalen_US
dc.subject.meshDoxorubicinen_US
dc.subject.meshDrug carriersen_US
dc.subject.meshDrug liberationen_US
dc.subject.meshFluorescent dyesen_US
dc.subject.meshFolic aciden_US
dc.subject.meshHeLa cellsen_US
dc.subject.meshHumansen_US
dc.subject.meshNanoconjugatesen_US
dc.subject.meshOptical imagingen_US
dc.subject.meshParticle sizeen_US
dc.subject.meshPolyethylene glycolsen_US
dc.subject.meshQuantum dotsen_US
dc.subject.meshSilver compoundsen_US
dc.subject.meshSurface propertiesen_US
dc.subject.scopusNanocrystal; Cdte; Forster Resonance Energy Transferen_US
dc.subject.wosNanoscience & nanotechnologyen_US
dc.subject.wosBiotechnology & applied microbiologyen_US
dc.titleFolic acid-conjugated cationic Ag2S quantum dots for optical imaging and selective doxorubicin delivery to HeLa cellsen_US
dc.typeArticle
dc.wos.quartileQ1 (Biotechnology & applied microbiology)en_US
dc.wos.quartileQ2 (Nanoscience & nanotechnology)en_US

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