Tedavi sonrasında tümör lizis sendromu gelişen iki hodgkin dışı lenfoma olgusu
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Date
1998
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Publisher
Uludağ Üniversitesi
Abstract
Akut tümör lizis sendromu (TLS), hızlı prolifere olan malign tümör/erin tedavisi sırasında; nadiren de spontan olarak gelişen fatal bir sendromdur. Takdim edilen olgulardan ilki; boyunda hızlı büyüyen kitle sebebi ile başvurmuştu ve yapılan biyopsi sonucunda Diffüz Büyük Hücreli lenfoma tanısı konularak tedavi başlandı. ikinci olgu ise, anemi ve boyunda lenfadenopati nedeni ile başvurmuş sonrasında lenfoblastik lenfoma tanısı konularak tedaviye başlanmıştır. Her iki vakada da tedaviyi takiben TLS gelişmesi nedeni ile nadir görülen bu klinik tablo literatür bilgilerinin ışığı altında gözden geçirildi.
Acute tumor lysis syndrome is a well characterized syndrome usually seen after aggressive cytotoxic chemotherapy for rapidly proliferating tumors. In this case report we aimed to present two cases with acute tumor lysis dr . First patient administered with a rapidly growing mass in the neck. Diagnosis of '"intermediate Grade Diffuse Large Cell Lymphoma" was made after excisional biopsy. Second patient presented by anemia and lymphadenopathy in the neck and diagnosed as ""High Grade Lymphoblastic Lymphoma" Following therapy Tumor Lysis Syndrome was observed in both patient.Clinical and laboratory findings of this rare clinical picture which was seen especially in lymphoproliferative diseases and occasionally in solid tumors after chemotherapy has been evaluated. Also literature is reviewed.
Acute tumor lysis syndrome is a well characterized syndrome usually seen after aggressive cytotoxic chemotherapy for rapidly proliferating tumors. In this case report we aimed to present two cases with acute tumor lysis dr . First patient administered with a rapidly growing mass in the neck. Diagnosis of '"intermediate Grade Diffuse Large Cell Lymphoma" was made after excisional biopsy. Second patient presented by anemia and lymphadenopathy in the neck and diagnosed as ""High Grade Lymphoblastic Lymphoma" Following therapy Tumor Lysis Syndrome was observed in both patient.Clinical and laboratory findings of this rare clinical picture which was seen especially in lymphoproliferative diseases and occasionally in solid tumors after chemotherapy has been evaluated. Also literature is reviewed.
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Keywords
Tümör, Yıkım, Lenfoma, Kemoterapi, Tumor, Lysis, Lymphoma, Chemotherapy
Citation
Manavoğlu, O. vd. ''Tedavi sonrasında tümör lizis sendromu gelişen iki hodgkin dışı lenfoma olgusu''. Uludağ Üniversitesi Tıp Fakültesi Dergisi, 25(1-2-3), 53-55.