Involvement of the histaminergic system in cytidine 5'-diphosphocholine-induced reversal of critical haemorrhagic hypotension in rats

Simple item page
dc.contributor.authorJochem, Jerzy
dc.contributor.authorRybus-Kalinowska, Barbara
dc.contributor.authorFogel, Wiesława Agnieszka
dc.contributor.buuauthorSavci, Vahide
dc.contributor.buuauthorFiliz, Nihat Devrim
dc.contributor.buuauthorYalçın, Murat
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Farmakoloji ve Klinik Farmakoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Fizyoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-5600-8162tr_TR
dc.contributor.researcheridAAG-6956-2021tr_TR
dc.contributor.scopusid6603687024tr_TR
dc.contributor.scopusid36554151900tr_TR
dc.contributor.scopusid57192959734tr_TR
dc.date.accessioned2022-01-14T07:19:33Z
dc.date.available2022-01-14T07:19:33Z
dc.date.issued2010-02
dc.description.abstractCytidine 5'-diphosphocholine (CDP-choline) is an endogenously synthesized mononucleotide which exerts a variety of physiological effects by altering central cholinergic transmission. Administered intracerebroventricularly (i.c.v.) or intravenously, it reverses haemorrhagic hypotension in rats, apparently by the activation of central cholinergic receptors. The study was undertaken to investigate the involvement of the central histaminergic system in CDP-choline-mediated reversal of haemorrhagic hypotension. Experiments were carried out in male ketamine/xylazine-anaesthetised Wistar rats subjected to haemorrhagic hypotension of 20-26 mmHg. CDP-choline (2 mu mol; i.c.v.) administered at 5 min of critical hypotension produced a long-lasting pressor effect with increases in mean arterial pressure (MAP), heart rate (HR), and renal, hindquarters and mesenteric blood flows, resulting in a 100% survival at 2 h. The action was accompanied by approximately a 26% increase in extracellular histamine concentration at the posterior hypothalamus, as measured by microdialysis. Cardiovascular effects mediated by CDP-choline were almost completely blocked by pretreatment with H(1) receptor antagonist chlorpheniramine (50 nmol; i.c.v.), but not with H(2) receptor blocker ranitidine (25 nmol; icv) or H(3)/H(4) receptor antagonist thioperamide (50 nmol; i.c.v.). In conclusion, the present results show that the central histaminergic system, through the activation of H(1) histaminergic receptors, is involved in CDP-choline-induced resuscitating effect in haemorrhage-shocked rats.en_US
dc.identifier.citationJochem, J. vd. (2010). "Involvement of the histaminergic system in cytidine 5'-diphosphocholine-induced reversal of critical haemorrhagic hypotension in rats". Journal of Physiology and Pharmacology, 61(1), 37-43.en_US
dc.identifier.endpage43tr_TR
dc.identifier.issn0867-5910
dc.identifier.issue1tr_TR
dc.identifier.pubmed20228413tr_TR
dc.identifier.scopus2-s2.0-77954303379tr_TR
dc.identifier.startpage37tr_TR
dc.identifier.urihttp://hdl.handle.net/11452/24095
dc.identifier.volume61tr_TR
dc.identifier.wos000275392300006tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherPolish Physiological Societyen_US
dc.relation.collaborationYurt dışıtr_TR
dc.relation.journalJournal of Physiology and Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHaemorrhagic shocken_US
dc.subjectHistamineen_US
dc.subjectCytosine 5 '-diphosphocholineen_US
dc.subjectMicrodialysisen_US
dc.subjectMean arterial pressureen_US
dc.subjectHeart rateen_US
dc.subjectEndogenous central histamineen_US
dc.subjectInjected CDP-cholineen_US
dc.subjectBlood-pressureen_US
dc.subjectCardiovascular-responsesen_US
dc.subjectIncreasesen_US
dc.subjectReleaseen_US
dc.subjectStressen_US
dc.subjectBrainen_US
dc.subjectProstaglandisen_US
dc.subjectShocken_US
dc.subjectPhysiologyen_US
dc.subject.emtreeChlorpheniramineen_US
dc.subject.emtreeCiticolineen_US
dc.subject.emtreeHistamineen_US
dc.subject.emtreeRanitidineen_US
dc.subject.emtreeThioperamideen_US
dc.subject.emtreeCiticolineen_US
dc.subject.emtreeHistamineen_US
dc.subject.emtreeHistamine H1 receptoren_US
dc.subject.emtreeHistamine H1 receptor antagonisten_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeAnimal modelen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeCholinergic systemen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDrug efficacyen_US
dc.subject.emtreeDrug mechanismen_US
dc.subject.emtreeExtracellular spaceen_US
dc.subject.emtreeHeart rateen_US
dc.subject.emtreeHemorrhagic hypotensionen_US
dc.subject.emtreeKidney blood flowen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMean arterial pressureen_US
dc.subject.emtreeMesentery blood flowen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreePressor responseen_US
dc.subject.emtreeRaten_US
dc.subject.emtreeSurvival rateen_US
dc.subject.emtreeSurvival timeen_US
dc.subject.emtreeAnimalen_US
dc.subject.emtreeComparative studyen_US
dc.subject.emtreeHypotensionen_US
dc.subject.emtreePathophysiologyen_US
dc.subject.emtreePhysiologyen_US
dc.subject.emtreeShock, hemorrhagicen_US
dc.subject.emtreeWistar raten_US
dc.subject.meshAnimalsen_US
dc.subject.meshCytidine diphosphate cholineen_US
dc.subject.meshHistamineen_US
dc.subject.meshHistamine H1 antagonistsen_US
dc.subject.meshHypotensionen_US
dc.subject.meshMaleen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, wistaren_US
dc.subject.meshReceptors, histamine H1en_US
dc.subject.meshShock, hemorrhagicen_US
dc.subject.scopusHistamine H4 Receptors; Thioperamide; Chlorpheniramine Maleateen_US
dc.subject.wosPhysiologyen_US
dc.titleInvolvement of the histaminergic system in cytidine 5'-diphosphocholine-induced reversal of critical haemorrhagic hypotension in ratsen_US
dc.typeArticle
dc.wos.quartileQ3en_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Savcı_vd_2010.pdf
Size:
1.16 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Web of Science
Scopus