Investigation of ABCB1 gene polymorphism with colchicine response in Behçet's disease

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dc.contributor.buuauthorSarıcaoğlu, Hayriye
dc.contributor.buuauthorYılmaz, Mediha
dc.contributor.buuauthorKarkucak, Mutlu
dc.contributor.buuauthorÖztürk, Hülya Z.Y.
dc.contributor.buuauthorYakut, Tahsin
dc.contributor.buuauthorGülten, Tuna
dc.contributor.buuauthorBülbül, Emel Başkan
dc.contributor.buuauthorAydoğan, Kenan
dc.contributor.buuauthorDilek, Kamil
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Genetik Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Dermatoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Romatoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-0144-3263tr_TR
dc.contributor.researcheridAAH-1388-2021tr_TR
dc.contributor.scopusid6603722836tr_TR
dc.contributor.scopusid35148700000tr_TR
dc.contributor.scopusid35388323500tr_TR
dc.contributor.scopusid57197115377tr_TR
dc.contributor.scopusid6602802424tr_TR
dc.contributor.scopusid6505944216tr_TR
dc.contributor.scopusid6602518817tr_TR
dc.contributor.scopusid9739755800tr_TR
dc.contributor.scopusid56005080200tr_TR
dc.date.accessioned2021-12-29T12:03:21Z
dc.date.available2021-12-29T12:03:21Z
dc.date.issued2011
dc.description.abstractColchicine is commonly used in the treatment of Behcet's disease. However, some patients are unresponsive to colchicine treatment. Adenosine triphosphate-binding cassette subfamily B member 1 (ABCB1) transports colchicine out of cells. We investigated a possible association of C3435T polymorphism of the ABCB1 (MDR1) gene with colchicine response in patients with Behcet's disease. We randomly selected 97 patients with Behcet's disease, examined ABCB1 (MDR1) gene C3435T polymorphisms, and evaluated patient responses to colchicine. Forty-three patients were colchicine responsive, while the remaining 54 patients were unresponsive. No significant difference was found between genotypic and allelic frequencies of the ABCB1 C3435T polymorphisms in patients with Behcet's disease and healthy volunteers. Also, there was no significant difference among responsive and nonresponsive patients. We concluded that ABCB1 C3435T polymorphism is not associated with a colchicine response in patients with Behcet's disease.en_US
dc.identifier.citationSarıcaoğlu, H. vd. (2011). "Investigation of ABCB1 gene polymorphism with colchicine response in Behçet's disease". Genetics and Molecular Research, 10(1), 1-6.en_US
dc.identifier.endpage6tr_TR
dc.identifier.issn1676-5680
dc.identifier.issue1tr_TR
dc.identifier.pubmed21218380tr_TR
dc.identifier.scopus2-s2.0-79251515771tr_TR
dc.identifier.startpage1tr_TR
dc.identifier.urihttps://doi.org/10.4238/vol10-1gmr824
dc.identifier.urihttp://www.funpecrp.com.br/gmr/year2011/vol10-1/pdf/gmr824.pdf
dc.identifier.urihttp://hdl.handle.net/11452/23737
dc.identifier.volume10tr_TR
dc.identifier.wos000286527300001tr_TR
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherFunpec-Editoraen_US
dc.relation.journalGenetics and Molecular Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBiochemistry & molecular biologyen_US
dc.subjectGenetics & heredityen_US
dc.subjectBehcet's diseaseen_US
dc.subjectColchicineen_US
dc.subjectABCB1 geneen_US
dc.subjectPolymorphismen_US
dc.subjectFamilial mediterranean feveren_US
dc.subjectMultidrug-resistance geneen_US
dc.subjectP-glycoproteinen_US
dc.subjectClinical-relevanceen_US
dc.subjectMdr1en_US
dc.subjectAssociationen_US
dc.subjectEfficacyen_US
dc.subject.emtreeColchicineen_US
dc.subject.emtreeMultidrug resistance protein 1en_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBehcet diseaseen_US
dc.subject.emtreeDiarrheaen_US
dc.subject.emtreeDrug withdrawalen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeGene frequencyen_US
dc.subject.emtreeGenetic associationen_US
dc.subject.emtreeGenetic polymorphismen_US
dc.subject.emtreeGenotypeen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeLeukopeniaen_US
dc.subject.emtreeLiver dysfunctionen_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeRandomized controlled trialen_US
dc.subject.emtreeSide effecten_US
dc.subject.emtreeStomach diseaseen_US
dc.subject.emtreeTreatment responseen_US
dc.subject.meshAdulten_US
dc.subject.meshBehcet syndromeen_US
dc.subject.meshCase control studiesen_US
dc.subject.meshColchicineen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene frequencyen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshP-glycoproteinen_US
dc.subject.meshPolymorphism, single nucleotideen_US
dc.subject.scopusMDR Gene; Multidrug Resistance Protein 1; Restriction Fragment Length Polymorphismsen_US
dc.subject.wosBiochemistry & molecular biologyen_US
dc.subject.wosGenetics & heredityen_US
dc.titleInvestigation of ABCB1 gene polymorphism with colchicine response in Behçet's diseaseen_US
dc.typeArticle

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