Propolis ve arı sütü içeren cilt kremi: Antioksidan, anti-hyalüronidaz ve antimikrobiyal aktivitelerin değerlendirmesi
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Date
2023-10-24
Authors
Boyracı, Gülsüm Merve
Değirmenci , Atiye
Yıldız, Oktay
Çelebi , Zeynep Berin
Journal Title
Journal ISSN
Volume Title
Publisher
Bursa Uludağ Üniversitesi
Abstract
Propolis ve arı sütü eski çağlardan beri geleneksel ve modern tıpta çeşitli biyolojik aktivitelerinden dolayı kullanılmıştır. Günümüzde yapılan son çalışmalar bu ürünlerin cilt tedavisi ve bakımı alanındaki potansiyel uygulamalarını ortaya koymuştur. Bu çalışmanın amacı, cilt kremi üretiminde propolis ve arı sütünün potansiyel kullanımını incelemek ve arı ürünleriyle zenginleştirilmiş cilt kremi formülasyonunun anti-hiyalüronidaz, antioksidan ve antimikrobiyal aktivitesini değerlendirmektir. Ayrıca kremlerin farklı depolama sıcaklığı ve süresindeki fiziksel stabilitesi de incelenmiştir. Krem formülasyonunda arı sütü oranı (%0,5) sabit tutulurken propolis özütü %0,5-1,0-1,5 oranlarında kullanılmıştır. Çalışmada üretilen kremlerin pH değerleri 5,56 ile 6,02 aralığında değişmekte olup cilt pH değerine uygun bulunmuştur. Krem formülasyonunda propolis oranı arttıkça antioksidan aktivite değerlerinin istatistiksel olarak arttığı görülmüştür (p≤0,05). Krem örneklerinin anti-hiyalüronidaz aktivite analizi sonucu IC50 değerleri 0,1667-3,3460 g/mL krem olarak belirlenmiş ve en yüksek aktivite %1,5 propolis özütü ilaveli örnekte bulunmuştur. Propolis ve arı sütü ilaveli krem örneklerinin tamamı Bacillus cereus, Escherichia coli, Staphylococcus aureus, Staphylococcus epidermidis ve Candida albicans mikroorganizmalarına karşı inhibisyon göstermiştir. Hızlandırılmış stabilite testleri krem formülasyonun tüm stres koşullarına karşı dikkate değer bir stabiliteye sahip olduğunu göstermiştir. Bu çalışma kozmetik sektöründe doğal, sürdürülebilir ve güvenli cilt bakım ürünleri üretebilmek için krem formülasyonuna arı ürünlerini entegre etmenin uygulanabilirliğine dair kanıt sağlamaktadır.
Propolis and royal jelly have been used in traditional and modern medical practices since earlier times, owing to their diverse range of biological activities. Recent studies have demonstrated the potential application of these products in the field of skin treatment and care. The purpose of this study is toexamine the potential application of propolis and royal jelly in cream formulation and to evaluate theanti-hyaluronidase, antioxidant, and antimicrobial activities of skin cream formulation enriched withbee products. It was also investigated the physical stability of creams at various storage temperature sand durations. The cream formulation main tained a ratio of royal jelly at 0,5% while varying amount sof propolis extract ranging from 0,5% to 1,0% to 1,5% were utilized. The pH values of the cream sexamined in the study ranged from 5,56 to 6,02, indicating that they were compatible with the pH value of the skin. It was observed that the antioxidant activity values increased statistically as the propolis ratio increased in the cream formulation. As a result of the antihyaluronidase activity analysis of thecream samples, the IC 50 values were determined as 0,1667-3,3460 g/mL cream and the sample with1,5% propolis extract showed the highest activity. The cream samples with propolis and royal jellyexhibited inhibitory activity against Bacillus cereus, Escherichia coli, Staphylococcus aureus,Staphylococcus epidermidis, and Candida albicans. The results of accelerated stability testingindicate that the cream formulation exhibits exceptional stability when subjected to various stress situations. This study provides evidence of the feasibility of integrating bee products into cream formulation to produce natural, sustainable, and safe skin care products in the cosmetics industry.
Propolis and royal jelly have been used in traditional and modern medical practices since earlier times, owing to their diverse range of biological activities. Recent studies have demonstrated the potential application of these products in the field of skin treatment and care. The purpose of this study is toexamine the potential application of propolis and royal jelly in cream formulation and to evaluate theanti-hyaluronidase, antioxidant, and antimicrobial activities of skin cream formulation enriched withbee products. It was also investigated the physical stability of creams at various storage temperature sand durations. The cream formulation main tained a ratio of royal jelly at 0,5% while varying amount sof propolis extract ranging from 0,5% to 1,0% to 1,5% were utilized. The pH values of the cream sexamined in the study ranged from 5,56 to 6,02, indicating that they were compatible with the pH value of the skin. It was observed that the antioxidant activity values increased statistically as the propolis ratio increased in the cream formulation. As a result of the antihyaluronidase activity analysis of thecream samples, the IC 50 values were determined as 0,1667-3,3460 g/mL cream and the sample with1,5% propolis extract showed the highest activity. The cream samples with propolis and royal jellyexhibited inhibitory activity against Bacillus cereus, Escherichia coli, Staphylococcus aureus,Staphylococcus epidermidis, and Candida albicans. The results of accelerated stability testingindicate that the cream formulation exhibits exceptional stability when subjected to various stress situations. This study provides evidence of the feasibility of integrating bee products into cream formulation to produce natural, sustainable, and safe skin care products in the cosmetics industry.
Description
Keywords
Propolis, Arı sütü, Krem, Cilt yenileyici etki, Anti-hiyaluronidaz aktivite, Royal jelly, Cream, Skin regenerating effect, Anti-hyaluronidase activity
Citation
Boyracı, G. M. vd. (2023). "Propolis ve arı sütü içeren cilt kremi: Antioksidan, anti-hyalüronidaz ve antimikrobiyal aktivitelerin değerlendirmesi". Uludağ Arıcılık Dergisi, 23(2), 224-238.