Mortality predictors of Staphylococcus aureus bacteremia: A prospective multicenter study

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dc.contributor.buuauthorSınırtaş, Melda
dc.contributor.buuauthorAkalın, Halis
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Mikrobiyoloji Anabilim Dalı.tr_TR
dc.contributor.researcheridAAU-8952-2020tr_TR
dc.contributor.scopusid57112463700tr_TR
dc.contributor.scopusid57207553671tr_TR
dc.date.accessioned2022-10-12T08:45:45Z
dc.date.available2022-10-12T08:45:45Z
dc.date.issued2016-02-09
dc.descriptionÇalışmada 22 yazar bulunmaktadır. Bu yazarlardan sadece Bursa Uludağ Üniversitesi mensuplarının girişleri yapılmıştır.tr_TR
dc.description.abstractBackground: Staphylococcus aureus is one of the causes of both community and healthcare-associated bacteremia. The attributable mortality of S. aureus bacteremia (SAB) is still higher and predictors for mortality and clinical outcomes of this condition are need to be clarified. In this prospective observational study, we aimed to examine the predictive factors for mortality in patients with SAB in eight Turkish tertiary care hospitals. Methods: Adult patients with signs and symptoms of bacteremia with positive blood cultures for S. aureus were included. All data for episodes of SAB including demographics, clinical and laboratory findings, antibiotics, and outcome were recorded for a 3-year (2010-2012) period. Cox proportional hazard model with forward selection was used to assess the independent effect of risk factors on mortality. A 28-day mortality was the dependent variable in the Cox regression analysis. Results: A total of 255 episodes of SAB were enrolled. The median age of the patients was 59 years. Fifty-five percent of the episodes were considered as primary SAB and vascular catheter was the source of 42.1 %. Healthcare associated SAB was defined in 55.7 %. Blood cultures yielded methicillin-resistant S. aureus (MRSA) as a cause of SAB in 39.2 %. Initial empirical therapy was inappropriate in 28.2 %. Although overall mortality was observed in 52 (20.4 %), 28-day mortality rate was 15.3 %. Both the numbers of initial inappropriate empirical antibiotic treatment and the median hours to start an appropriate antibiotic between the cases of fatal outcome and survivors after fever onset were found to be similar (12/39 vs 60/216 and 6 vs 12 h, respectively; p > 0.05). High Charlson comorbidity index (CCI) score (p = 0.002), MRSA (p = 0.017), intensive care unit (ICU) admission (p < 0.001) and prior exposure to antibiotics (p = 0.002) all were significantly associated with mortality. The Cox analysis defined age [Hazard Ratio (HR) 1.03; p = 0.023], ICU admission (HR 6.9; p = 0.002), and high CCI score (HR 1.32; p = 0.002) as the independent predictive factors mortality. Conclusions: The results of this prospective study showed that age, ICU stay and high CCI score of a patient were the independent predictors of mortality and MRSA was also significantly associated with mortality in SAB.en_US
dc.identifier.citationYılmaz, M. vd. (2016). "Mortality predictors of Staphylococcus aureus bacteremia: A prospective multicenter study". Annals of Clinical Microbiology and Antimicrobials, 15(1).en_US
dc.identifier.issn1476-0711
dc.identifier.issue1tr_TR
dc.identifier.pubmed26860463tr_TR
dc.identifier.scopus2-s2.0-84957870054tr_TR
dc.identifier.urihttps://doi.org/10.1186/s12941-016-0122-8
dc.identifier.urihttps://ann-clinmicrob.biomedcentral.com/articles/10.1186/s12941-016-0122-8
dc.identifier.urihttp://hdl.handle.net/11452/29062
dc.identifier.volume15tr_TR
dc.identifier.wos000369571000002tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherBMCen_US
dc.relation.collaborationYurt içitr_TR
dc.relation.collaborationSanayitr_TR
dc.relation.journalAnnals of Clinical Microbiology and Antimicrobialsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMicrobiologyen_US
dc.subjectStaphylococcus aureusen_US
dc.subjectBacteremiaen_US
dc.subjectRisk factorsen_US
dc.subjectMortalityen_US
dc.subjectSepsisen_US
dc.subjectBlood-stream infectionen_US
dc.subjectHacettepe university adulten_US
dc.subjectMethicillin-resistanten_US
dc.subjectRisk-factorsen_US
dc.subjectClinical impacten_US
dc.subjectAntimicrobial therapyen_US
dc.subjectAntibiotic-treatmenten_US
dc.subject30-day mortalityen_US
dc.subjectEndocarditisen_US
dc.subjectEpidemiologyen_US
dc.subject.emtreeAmoxicillinen_US
dc.subject.emtreeCefazolinen_US
dc.subject.emtreeCefepimeen_US
dc.subject.emtreeCefoperazone plus sulbactamen_US
dc.subject.emtreeCeftazidimeen_US
dc.subject.emtreeCeftriaxoneen_US
dc.subject.emtreeCefuroximeen_US
dc.subject.emtreeDaptomycinen_US
dc.subject.emtreeImipenemen_US
dc.subject.emtreeLinezoliden_US
dc.subject.emtreeMeropenemen_US
dc.subject.emtreePiperacillin plus tazobactamen_US
dc.subject.emtreeSultamicillinen_US
dc.subject.emtreeTeicoplaninen_US
dc.subject.emtreeTimentinen_US
dc.subject.emtreeVancomycinen_US
dc.subject.emtreeAntiinfective agenten_US
dc.subject.emtreeAdolescenten_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBlood cultureen_US
dc.subject.emtreeCharlson comorbidity indexen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDemographyen_US
dc.subject.emtreeDependent variableen_US
dc.subject.emtreeDrug exposureen_US
dc.subject.emtreeFatalityen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeIntensive care uniten_US
dc.subject.emtreeIntravascular catheteren_US
dc.subject.emtreeLaboratory testen_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMethicillin resistant staphylococcus aureusen_US
dc.subject.emtreeMortalityen_US
dc.subject.emtreeMulticenter studyen_US
dc.subject.emtreeObservational studyen_US
dc.subject.emtreeProspective studyen_US
dc.subject.emtreeRisk factoren_US
dc.subject.emtreeScoring systemen_US
dc.subject.emtreeStaphylococcal bacteremiaen_US
dc.subject.emtreeStaphylococcus aureusen_US
dc.subject.emtreeSymptomatologyen_US
dc.subject.emtreeTertiary health careen_US
dc.subject.emtreeAgeden_US
dc.subject.emtreeBacteremiaen_US
dc.subject.emtreeClassificationen_US
dc.subject.emtreeClinical trialen_US
dc.subject.emtreeGeneticsen_US
dc.subject.emtreeIsolation and purificationen_US
dc.subject.emtreeMicrobiologyen_US
dc.subject.emtreeMiddle ageden_US
dc.subject.emtreeMortalityen_US
dc.subject.emtreeStaphylococcus infectionen_US
dc.subject.emtreeStatistics and numerical dataen_US
dc.subject.emtreeTurkeyen_US
dc.subject.emtreeVery elderlyen_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 and overen_US
dc.subject.meshAnti-bacterial agentsen_US
dc.subject.meshBacteremiaen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIntensive care unitsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshProspective studiesen_US
dc.subject.meshStaphylococcal infectionsen_US
dc.subject.meshStaphylococcus aureusen_US
dc.subject.meshTurkeyen_US
dc.subject.scopusBacteremia; Staphylococcal Infections; Staphylococcus Aureusen_US
dc.subject.wosMicrobiologyen_US
dc.titleMortality predictors of Staphylococcus aureus bacteremia: A prospective multicenter studyen_US
dc.typeArticle

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