Apoptosis-inducing effect of a palladium(II) complex-[PdCl(terpy)](sac)center dot 2H2O] on ehrlich ascites carcinoma (EAC) in mice

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dc.contributor.authorİkitimur, Elif I. Armutak
dc.contributor.authorGürel, Ebru Gürevin
dc.contributor.authorYaylım, İlhan
dc.contributor.authorİşbilen, Banu Başok
dc.contributor.authorŞennazlı, Gülbin
dc.contributor.authorYüzbaşıoğlu, Gülay Öztürk
dc.contributor.authorSönmez, Kıvılcım
dc.contributor.authorÇelik, Faruk
dc.contributor.authorKüçükhüseyin, Özlem
dc.contributor.authorKorkmaz, Gurbet
dc.contributor.authorZeybek, Şakir Ümit
dc.contributor.buuauthorUlukaya, Engin
dc.contributor.buuauthorYılmaz, Veysel T.
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyokimya Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Fen-Edebiyat Fakültesi/Kimya Bölümü.tr_TR
dc.contributor.orcid0000-0002-2849-3332tr_TR
dc.contributor.researcheridK-5792-2018tr_TR
dc.contributor.researcheridL-7238-2018tr_TR
dc.contributor.scopusid6602927353tr_TR
dc.contributor.scopusid56441123900tr_TR
dc.date.accessioned2022-12-02T11:25:45Z
dc.date.available2022-12-02T11:25:45Z
dc.date.issued2016-04-28
dc.description.abstractBackground/Aim: New compounds for cancer treatment are needed due to persistenly unsatisfactory management of cancer. [PdCl(terpy)](sac)center dot 2H2O] (sac= saccharinate, and terpy= 2,2':6',2 ''- terpyridine) is a compound synthesized for this purpose. We investigated its anti-proliferative and pro-apoptotic effects on Ehrlich Ascites Carcinoma (EAC) in vivo. Materials and Methods: 42 Balb-c female mice were subcutaneously (s.c.) injected with EAC cells (1st day) and then randomly divided into 5 groups: control (0.9% NaCl), complex (2 mg/kg), complex (3 mg/kg) cisplatin (4 mg/kg) and paclitaxel (12.5 mg/kg). On the 5th and 12th day animals were drug administrated. At 14th day, animals were sacrificed. Expression of cell death and/or cell cycle-related markers (Bcl-2, Bax, active caspase-3, p53, PCNA) and apoptosis were investigated immunohisto-chemically. Survival-related markers (Akt, GSK-3 beta, IGF-1R, IR, IRS-1, p70S6K, PRAS40) were evaluated by luminex analysis. Results: Expression of p53, PCNA, Bcl-2 was found decreased (p< 0.001) and that of active caspase-3, Bax, and apoptotic cells was found increased (p< 0.001) in all groups. The survivalrelated markers did not show any statistical difference in complex groups. Conclusion: The Pd(II)-complex seems to have a strong anticancer activity on EAC by inducing apoptosis via both suppression of proliferation and activation of apoptosis in vivo, similar to the effects of cisplatin and paclitaxel.en_US
dc.description.sponsorshipİstanbul Üniversitesi- 30869tr_TR
dc.identifier.citationİkitimur, A. E. I. vd. (2016). "Apoptosis-inducing effect of a palladium(II) complex-[PdCl(terpy)](sac)center dot 2H2O] on ehrlich ascites carcinoma (EAC) in mice". In Vivo, 30(4), 457-464.en_US
dc.identifier.endpage464tr_TR
dc.identifier.issn0258-851X
dc.identifier.issn1791-7549
dc.identifier.issue4tr_TR
dc.identifier.pubmed27381609tr_TR
dc.identifier.scopus2-s2.0-85008188162tr_TR
dc.identifier.startpage457tr_TR
dc.identifier.urihttps://iv.iiarjournals.org/content/30/4/457.short
dc.identifier.urihttp://hdl.handle.net/11452/29655
dc.identifier.volume30tr_TR
dc.identifier.wos000379486900016tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherInt Inst Anticancer Researchen_US
dc.relation.collaborationYurt içitr_TR
dc.relation.journalIn Vivoen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectResearch & experimental medicineen_US
dc.subjectPd(II) complexen_US
dc.subjectEACen_US
dc.subjectBreast canceren_US
dc.subjectApoptosisen_US
dc.subjectIn vivoen_US
dc.subjectBreast-cancer cellsen_US
dc.subjectNuclear antigen immunohistochemistryen_US
dc.subjectGene bax-alphaen_US
dc.subjectInsulin-receptor substrate-1en_US
dc.subjectSaccharinate complexen_US
dc.subjectIn-vitroen_US
dc.subjectTumor-growthen_US
dc.subjectDeathen_US
dc.subjectPhosphorylationen_US
dc.subjectTerpyridineen_US
dc.subject.emtreeAntineoplastic agenten_US
dc.subject.emtreeApoptosis inducing factoren_US
dc.subject.emtreeCisplatinen_US
dc.subject.emtreeCoordination compounden_US
dc.subject.emtreePalladiumen_US
dc.subject.emtreeAnimalen_US
dc.subject.emtreeApoptosisen_US
dc.subject.emtreeBagg albino mouseen_US
dc.subject.emtreeCarcinoma, ehrlich tumoren_US
dc.subject.emtreeCell proliferationen_US
dc.subject.emtreeChemistryen_US
dc.subject.emtreeCombination drug therapyen_US
dc.subject.emtreeDrug effectsen_US
dc.subject.emtreeEnzyme immunoassayen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeMetabolismen_US
dc.subject.emtreeMouseen_US
dc.subject.emtreePathologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntineoplastic agentsen_US
dc.subject.meshApoptosisen_US
dc.subject.meshApoptosis inducing factoren_US
dc.subject.meshCarcinoma, ehrlich tumoren_US
dc.subject.meshCell proliferationen_US
dc.subject.meshCisplatinen_US
dc.subject.meshCoordination complexesen_US
dc.subject.meshDrug therapy, combinationen_US
dc.subject.meshFemaleen_US
dc.subject.meshImmunoenzyme techniquesen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, inbred BALB Cen_US
dc.subject.meshPalladiumen_US
dc.subject.scopusComplex; Palladium; 2-Phenylpyridineen_US
dc.subject.wosMedicine, research & experimentalen_US
dc.titleApoptosis-inducing effect of a palladium(II) complex-[PdCl(terpy)](sac)center dot 2H2O] on ehrlich ascites carcinoma (EAC) in miceen_US
dc.typeArticle
dc.wos.quartileQ4en_US

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