Peripheral GLP-1 gastroprotection against ethanol: The role of exendin, NO, CGRP, prostaglandins and blood flow

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dc.contributor.buuauthorİşbil, Naciye Büyükcoşkun
dc.contributor.buuauthorGüleç, Güldal
dc.contributor.buuauthorÇam, Betül Etöz
dc.contributor.buuauthorÖzlük, Kasım
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Fizyoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0003-0863-1547tr_TR
dc.contributor.researcheridC-5730-2015tr_TR
dc.contributor.researcheridAAH-1692-2021tr_TR
dc.contributor.scopusid55665951400tr_TR
dc.contributor.scopusid6602752303tr_TR
dc.contributor.scopusid24179406800tr_TR
dc.contributor.scopusid6602676331tr_TR
dc.date.accessioned2022-01-18T10:53:22Z
dc.date.available2022-01-18T10:53:22Z
dc.date.issued2009-01-08
dc.description.abstractThe aim of this study was to investigate the effects of peripherally injected glucagon like peptide-1 (GLP-1) on ethanol-induced gastric mucosal damage and the mechanisms included in the effect. Absolute ethanol was administered through an orogastric cannula right after the injection of GLP-1 (1, 10, 100, 1000 or 10,000 ng/kg; i.p.). The rats were decapitated an hour later, the stomachs removed and the gastric mucosal damage scored. 1000 ng GLP-1 inhibited gastric mucosal damage by 45% and 10,000 ng GLP-1 by 60%. The specific receptor antagonist exendin-(9-39) (2500 ng/kg; i.p.), calcitonin gene related peptide (CGRP) receptor antagonist CGRP-(8-37) (10 pg/kg; i.p.), nitric oxide (NO) synthase inhibitor L-NAME (30 mg/kg; s.c) and cyclooxygenase inhibitor indomethacin (5 mg/kg; i.p.) inhibited the preventive effect of GLP-1 on ethanol-induced gastric mucosal damage. GLP-1 also prevented the decrease in gastric mucosal blood flow caused by ethanol when administered at gastroprotective doses (1000 and 10,000 ng/kg: i.p.). In conclusion, GLP-1 administered peripherally prevents the gastric mucosal damage caused by ethanol in rats. CGRR NO, prostaglandin and gastric mucosal blood flow are thought to play a role in this effect, mediated through receptors specific to GLP-1.en_US
dc.identifier.citationİşbil, N. B. vd. (2009). "Peripheral GLP-1 gastroprotection against ethanol: The role of exendin, NO, CGRP, prostaglandins and blood flow". Regulatory Peptides, 152(1-3), 22-27.en_US
dc.identifier.endpage27tr_TR
dc.identifier.issn0167-0115
dc.identifier.issue1-3tr_TR
dc.identifier.pubmed18926859tr_TR
dc.identifier.scopus2-s2.0-57249097116tr_TR
dc.identifier.startpage22tr_TR
dc.identifier.urihttps://doi.org/10.1016/j.regpep.2008.09.006
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S016701150800164X
dc.identifier.urihttp://hdl.handle.net/11452/24138
dc.identifier.volume152tr_TR
dc.identifier.wos000262748500004tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.bapT-2004/17tr_TR
dc.relation.journalRegulatory Peptidesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCGRP-(8-37)en_US
dc.subjectExendin-(9-39)en_US
dc.subjectGastric mucosal blood flowen_US
dc.subjectGastric mucosal damageen_US
dc.subjectGlucagon like peptide-1en_US
dc.subjectIndomethacinen_US
dc.subjectl-NAMEen_US
dc.subjectGlucagon-like peptide-1en_US
dc.subjectGene-related peptideen_US
dc.subjectGastric somatostatinen_US
dc.subjectExperimental-modelsen_US
dc.subjectRaten_US
dc.subjectReceptoren_US
dc.subjectLesionsen_US
dc.subjectAmylinen_US
dc.subjectAmideen_US
dc.subjectMechanismsen_US
dc.subjectEndocrinology & metabolismen_US
dc.subjectPhysiologyen_US
dc.subjectRattusen_US
dc.subject.emtreeAlcoholen_US
dc.subject.emtreeCalcitonin gene related peptide[8-37]en_US
dc.subject.emtreeExendin 4en_US
dc.subject.emtreeExendin[9-39]en_US
dc.subject.emtreeGlucagon like peptide 1en_US
dc.subject.emtreeGlucagon like peptide 1 receptoren_US
dc.subject.emtreeIndometacinen_US
dc.subject.emtreeN(g) nitroarginine methyl esteren_US
dc.subject.emtreeNitric oxideen_US
dc.subject.emtreeProstaglandin derivativeen_US
dc.subject.emtreeUnclassified drugen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeAnimal modelen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDrug effecten_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreePeptide analysisen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeProtein functionen_US
dc.subject.emtreeRaten_US
dc.subject.emtreeStomach blood flowen_US
dc.subject.emtreeStomach mucosa lesionen_US
dc.subject.emtreeStomach protectionen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCalcitonin gene-related peptideen_US
dc.subject.meshEthanolen_US
dc.subject.meshGastric mucosaen_US
dc.subject.meshGlucagon-like peptide 1en_US
dc.subject.meshIndomethacinen_US
dc.subject.meshMaleen_US
dc.subject.meshNG-nitroarginine methyl esteren_US
dc.subject.meshNitric oxideen_US
dc.subject.meshPeptide fragmentsen_US
dc.subject.meshProstaglandinsen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, sprague-dawleyen_US
dc.subject.meshRegional blood flowen_US
dc.subject.scopusGlucagon-Like Peptide-1 Receptor; Gastric Inhibitory Polypeptide; Exendin (9-39)en_US
dc.subject.wosEndocrinology & metabolismen_US
dc.subject.wosPhysiologyen_US
dc.titlePeripheral GLP-1 gastroprotection against ethanol: The role of exendin, NO, CGRP, prostaglandins and blood flowen_US
dc.typeArticle
dc.wos.quartileQ3en_US

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