In vivo systemic chlorogenic acid therapy under diabetic conditions: Wound healing effects and cytotoxicity/genotoxicity profile

Simple item page
dc.contributor.buuauthorBağdaş, Deniz
dc.contributor.buuauthorEtöz, Betül Cam
dc.contributor.buuauthorGül, Zülfiye
dc.contributor.buuauthorZiyanok, Sedef
dc.contributor.buuauthorİnan, Sevda
dc.contributor.buuauthorTuraçözen, Özge
dc.contributor.buuauthorGül, Nihal
dc.contributor.buuauthorTopal, Ayşe B.
dc.contributor.buuauthorÇinkılıç, Nilüfer
dc.contributor.buuauthorTaş, Sibel
dc.contributor.buuauthorÖzyiğit, Musa Özgür
dc.contributor.buuauthorGürün, Mine Sibel
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Deney Hayvanları Yetiştirme ve Araştırma Merkezi.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Fizyoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Farmakoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Fen ve Edebiyat Fakültesi/Biyoloji Bölümü.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Veteriner Fakültesi/Patoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Veteriner Fakültesi/Cerrahi Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-8872-0074tr_TR
dc.contributor.orcid0000-0002-3595-6286tr_TR
dc.contributor.orcid0000-0001-8138-5851tr_TR
dc.contributor.researcheridAAR-6478-2021tr_TR
dc.contributor.researcheridAAF-9939-2020tr_TR
dc.contributor.researcheridAAG-8716-2019tr_TR
dc.contributor.researcheridE-3364-2018tr_TR
dc.contributor.researcheridABE-6873-2020tr_TR
dc.contributor.researcheridAAH-4272-2021tr_TR
dc.contributor.researcheridAAH-2873-2021tr_TR
dc.contributor.researcheridAAH-5296-2021tr_TR
dc.contributor.scopusid15062425700tr_TR
dc.contributor.scopusid56427863700tr_TR
dc.contributor.scopusid56086542900tr_TR
dc.contributor.scopusid9735158200tr_TR
dc.contributor.scopusid56320836200tr_TR
dc.contributor.scopusid56320248500tr_TR
dc.contributor.scopusid8387784600tr_TR
dc.contributor.scopusid56357211200tr_TR
dc.contributor.scopusid26533892300tr_TR
dc.contributor.scopusid7004343411tr_TR
dc.contributor.scopusid6507338060tr_TR
dc.contributor.scopusid55664349700tr_TR
dc.date.accessioned2022-06-09T11:35:25Z
dc.date.available2022-06-09T11:35:25Z
dc.date.issued2015-07
dc.description.abstractOxidative stress occurs following the impairment of pro-oxidant/antioxidant balance in chronic wounds and leads to harmful delays in healing progress. A fine balance between oxidative stress and endogenous antioxidant defense system may be beneficial for wound healing under redox control. This study tested the hypothesis that oxidative stress in wound area can be controlled with systemic antioxidant therapy and therefore wound healing can be accelerated. We used chlorogenic acid (CGA), a dietary antioxidant, in experimental diabetic wounds that are characterized by delayed healing. Additionally, we aimed to understand possible side effects of CGA on pivotal organs and bone marrow during therapy. Wounds were created on backs of streptozotocin-induced diabetic rats. CGA (50 mg/kg/day) was injected intraperitoneally. Animals were sacrificed on different days. Biochemical and histopathological examinations were performed. Side effects of chronic antioxidant treatment were tested. CGA accelerated wound healing, enhanced hydroxyproline content, decreased malondialdehyde/nitric oxide levels, elevated reduced-glutathione, and did not affect superoxide dismutase/catalase levels in wound bed. While CGA induced side effects such as cyto/genotoxicity, 15 days of treatment attenuated blood glucose levels. CGA decreased lipid peroxidation levels of main organs. This study provides a better understanding for antioxidant intake on diabetic wound repair and possible pro-oxidative effects.en_US
dc.identifier.citationBağdaş, D. vd. (2015). "In vivo systemic chlorogenic acid therapy under diabetic conditions: Wound healing effects and cytotoxicity/genotoxicity profile". Food and Chemical Toxicology, 81, 54-61.en_US
dc.identifier.endpage61tr_TR
dc.identifier.issn0278-6915
dc.identifier.pubmed25846499tr_TR
dc.identifier.scopus2-s2.0-84928128269tr_TR
dc.identifier.startpage54tr_TR
dc.identifier.urihttps://doi.org/10.1016/j.fct.2015.04.001
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0278691515001106
dc.identifier.urihttp://hdl.handle.net/11452/27002
dc.identifier.volume81tr_TR
dc.identifier.wos000356740500007tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Scienceen_US
dc.relation.bapKUAP (T) 2012/37tr_TR
dc.relation.bapHDP (T) 2012/33tr_TR
dc.relation.journalFood and Chemical Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChlorogenic aciden_US
dc.subjectAntioxidanten_US
dc.subjectOxidative stressen_US
dc.subjectDiabetic wound healingen_US
dc.subjectCytotoxicityen_US
dc.subjectGenotoxicityen_US
dc.subjectCaffeic aciden_US
dc.subjectOxidative stressen_US
dc.subjectNitric-oxideen_US
dc.subjectProoxidant activitiesen_US
dc.subjectTopical applicationen_US
dc.subjectPhenethyl esteren_US
dc.subjectInstant coffeeen_US
dc.subjectDna-damageen_US
dc.subjectRat modelen_US
dc.subjectAntioxidanten_US
dc.subjectFood science & technologyen_US
dc.subjectToxicologyen_US
dc.subjectAnimaliaen_US
dc.subjectRattusen_US
dc.subject.emtreeCatalaseen_US
dc.subject.emtreeChlorogenic aciden_US
dc.subject.emtreeGlucoseen_US
dc.subject.emtreeGlutathioneen_US
dc.subject.emtreeHydroxyprolineen_US
dc.subject.emtreeMalonaldehydeen_US
dc.subject.emtreeNitric oxideen_US
dc.subject.emtreeSuperoxide dismutaseen_US
dc.subject.emtreeAntioxidanten_US
dc.subject.emtreeCatalaseen_US
dc.subject.emtreeChlorogenic aciden_US
dc.subject.emtreeGlucose blood levelen_US
dc.subject.emtreeGlutathioneen_US
dc.subject.emtreeHydroxyprolineen_US
dc.subject.emtreeMalonaldehydeen_US
dc.subject.emtreeNitric oxideen_US
dc.subject.emtreeReactive oxygen metaboliteen_US
dc.subject.emtreeStreptozocinen_US
dc.subject.emtreeSuperoxide dismutaseen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeAnimal modelen_US
dc.subject.emtreeAnimal tissueen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBiochemistryen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeCytotoxicityen_US
dc.subject.emtreeDiabetes mellitusen_US
dc.subject.emtreeDrug efficacyen_US
dc.subject.emtreeDrug mechanismen_US
dc.subject.emtreeDrug safetyen_US
dc.subject.emtreeGenotoxicityen_US
dc.subject.emtreeGlucose blood levelen_US
dc.subject.emtreeHistopathologyen_US
dc.subject.emtreeIn vivo studyen_US
dc.subject.emtreeLipid peroxidationen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreeOxidative stressen_US
dc.subject.emtreeWounden_US
dc.subject.emtreeRaten_US
dc.subject.emtreeWound healingen_US
dc.subject.emtreeAnimalen_US
dc.subject.emtreeDNA damageen_US
dc.subject.emtreeDrug effectsen_US
dc.subject.emtreeExperimental diabetes mellitusen_US
dc.subject.emtreeMetabolismen_US
dc.subject.emtreeMetabolismen_US
dc.subject.emtreePathologyen_US
dc.subject.emtreeSprague Dawley raten_US
dc.subject.emtreeWound healingen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntioxidantsen_US
dc.subject.meshBlood glucoseen_US
dc.subject.meshCatalaseen_US
dc.subject.meshChlorogenic aciden_US
dc.subject.meshDiabetes mellitus, experimentalen_US
dc.subject.meshDNA damageen_US
dc.subject.meshGlutathioneen_US
dc.subject.meshHydroxyprolineen_US
dc.subject.meshLipid peroxidationen_US
dc.subject.meshMaleen_US
dc.subject.meshMalondialdehydeen_US
dc.subject.meshNitric oxideen_US
dc.subject.meshOxidative stressen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, sprague-dawleyen_US
dc.subject.meshReactive oxygen speciesen_US
dc.subject.meshStreptozocinen_US
dc.subject.meshSuperoxide dismutaseen_US
dc.subject.meshWound healingen_US
dc.subject.scopusAntioxidant; Carlina Oxide; Loniceraen_US
dc.subject.wosFood science & technologyen_US
dc.subject.wosToxicologyen_US
dc.titleIn vivo systemic chlorogenic acid therapy under diabetic conditions: Wound healing effects and cytotoxicity/genotoxicity profileen_US
dc.typeArticle
dc.wos.quartileQ1en_US

Files

License bundle
Now showing 1 - 1 of 1
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Web of Science
Scopus