Age-related changes in the rat hippocampus

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dc.contributor.authorİş, Merih
dc.contributor.authorComunoğlu, Cem
dc.contributor.authorEkici, Işın Doğan
dc.contributor.authorÖzkan, Ferda
dc.contributor.authorComunoğlu, Nil
dc.contributor.buuauthorEren, Bülent
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Adli Tıp Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-2319-1757tr_TR
dc.contributor.researcheridAAU-7408-2020tr_TR
dc.contributor.researcheridAAK-8096-2021tr_TR
dc.contributor.researcheridAAX-8590-2021tr_TR
dc.contributor.scopusid8725969000tr_TR
dc.date.accessioned2022-03-16T13:25:50Z
dc.date.available2022-03-16T13:25:50Z
dc.date.issued2008-05
dc.description.abstractThe human brain is uniquely powerful in its cognitive abilities, yet the hippocampal and neocortical circuits that mediate these complex functions are highly vulnerable during aging. In this study, we analyzed age-related changes in the rat hippocampus by studying newborn (1 month), middle-aged (12 months), and older (24 months) male and female Sprague-Dawley rats. We evaluated neuronal dystrophy, neuron scattering, and granulovacuolar degeneration in the hippocampal area using light microscopy, according to age and gender. We detected significant neuronal dystrophy in the CA1, CA2, and CA3 areas in male rats, and in the CA1, CA3, and CA4 areas in female rats. Degenerative changes, indicated by neuron scattering, were observed in the CA1, CA2, and CA3 areas of male and the CA2 and CA4 areas of female rats. Changes in all areas of the hippocampus were observed with increasing age; these changes included neuronal dystrophy and neuron scattering and did not differ significantly between male and female rats.en_US
dc.identifier.citationİş, M. vd. (2008). "Age-related changes in the rat hippocampus". Journal of Clinical Neuroscience, 15(5), 568-574.en_US
dc.identifier.endpage574tr_TR
dc.identifier.issn0967-5868
dc.identifier.issn1532-2653
dc.identifier.issue5tr_TR
dc.identifier.pubmed18342510tr_TR
dc.identifier.scopus2-s2.0-41549141204tr_TR
dc.identifier.startpage568tr_TR
dc.identifier.urihttps://doi.org/10.1016/j.jocn.2007.03.025
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0967586807003062
dc.identifier.urihttp://hdl.handle.net/11452/25101
dc.identifier.volume15tr_TR
dc.identifier.wos000255339000014
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.collaborationYurt içitr_TR
dc.relation.collaborationSanayitr_TR
dc.relation.journalJournal of Clinical Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNeurosciences & neurologyen_US
dc.subjectAgingen_US
dc.subjectGranulovacuolar degenerationen_US
dc.subjectHippocampusen_US
dc.subjectNeuron scatteringen_US
dc.subjectNeuronal dystrophyen_US
dc.subjectGranulovacuolar degenerationen_US
dc.subjectAlzheimers-diseaseen_US
dc.subjectBrainen_US
dc.subjectImpairmenten_US
dc.subjectNeuronsen_US
dc.subjectNumberen_US
dc.subject.emtreeAgingen_US
dc.subject.emtreeAgeen_US
dc.subject.emtreeAnimal tissueen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeCell damageen_US
dc.subject.emtreeCell degenerationen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeGenderen_US
dc.subject.emtreeGranulovacuolar degenerationen_US
dc.subject.emtreeHippocampusen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMicroscopyen_US
dc.subject.emtreeNeuron scatteringen_US
dc.subject.emtreeNeuronal dystrophyen_US
dc.subject.emtreeNewbornen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeRaten_US
dc.subject.meshAge factorsen_US
dc.subject.meshAgingen_US
dc.subject.meshAmyloid beta-protein precursoren_US
dc.subject.meshAnimalsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHippocampusen_US
dc.subject.meshMaleen_US
dc.subject.meshNerve degenerationen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, sprague-dawleyen_US
dc.subject.meshSex factorsen_US
dc.subject.meshNeuronsen_US
dc.subject.scopusNeurofibrillary Tangles; Degeneration; Lewy Bodiesen_US
dc.subject.wosClinical neurologyen_US
dc.subject.wosNeurosciencesen_US
dc.titleAge-related changes in the rat hippocampusen_US
dc.typeArticle
dc.wos.quartileQ4en_US

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