Time-dependent alterations in growth and bone health parameters evaluated at different posttreatment periods in pediatric oncology patients

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dc.contributor.buuauthorDemirkaya, Metin
dc.contributor.buuauthorSevinir, Betül Berrin
dc.contributor.buuauthorSaǧlam, Halil
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Pediatri Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0003-0710-5422tr_TR
dc.contributor.researcheridAAH-1570-2021tr_TR
dc.contributor.researcheridC-7392-2019tr_TR
dc.contributor.scopusid24331130000tr_TR
dc.contributor.scopusid6603199915tr_TR
dc.contributor.scopusid35612700100tr_TR
dc.date.accessioned2022-02-18T11:16:15Z
dc.date.available2022-02-18T11:16:15Z
dc.date.issued2011-10
dc.description.abstractBone mineral density (BMD) and anthropometric measurements in pediatric cancer patients were evaluated and compared at early and late posttreatment periods. Sixty-six pediatric cancer patients who recovered completely following treatment longer than at least a 6-month period were included in the study. Patients were evaluated cross-sectionally and prospectively with regard to anthropometric measurements and BMD twice; the first being at a mean period of 2.62 +/- 1.44 years and the second of 6.55 +/- 1.71 years after the completion of treatment. Rates of osteoporosis and osteopenia at first or second evaluation were 25.8% and 39.4% or 10.6% and 19.7%, respectively. Mean BMD z-scores were (-1.26) +/- 1.12 [(-4.3)-2.0] and (-0.48) +/- 1.25 [(-3.30)-3.40] at first and second evaluations, respectively. BMD findings obtained at second evaluation revealed statistically significant recovery compared with those obtained at first evaluation (P = .001). BMD z-scores were significantly lower in patients who received, as opposed to those who did not receive, radiotherapy (RT) at both evaluations. Anthropometric parameters of patients such as height, weight, and body mass index (BMI) were increased at both evaluations compared with values obtained at diagnosis (P < .05). Height standard deviation score (SDS) decreased at first evaluation compared with that measured at diagnosis, whereas it increased at second evaluation. Conversely, weight SDS and BMI SDS increased (P < .05) at first evaluation compared with that measured at diagnosis, whereas they decreased at second evaluation. The authors conclude that early impairments in anthropometric measurements recover in the long term, whereas BMD is continually reduced in children who recovered from cancer.en_US
dc.identifier.citationDemirkaya, M. vd. (2011). "Time-dependent alterations in growth and bone health parameters evaluated at different posttreatment periods in pediatric oncology patients". Pediatric Hematology and Oncology, 28(7), 588-599.en_US
dc.identifier.endpage599tr_TR
dc.identifier.issn0888-0018
dc.identifier.issn1521-0669
dc.identifier.issue7tr_TR
dc.identifier.pubmed21936621tr_TR
dc.identifier.scopus2-s2.0-80053069065tr_TR
dc.identifier.startpage588tr_TR
dc.identifier.urihttps://doi.org/10.3109/08880018.2011.603819
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.3109/08880018.2011.603819
dc.identifier.urihttp://hdl.handle.net/11452/24529
dc.identifier.volume28tr_TR
dc.identifier.wos000295084800005tr_TR
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherTaylor & Francisen_US
dc.relation.journalPediatric Hematology and Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOncologyen_US
dc.subjectHematologyen_US
dc.subjectPediatricsen_US
dc.subjectAnthropometricen_US
dc.subjectBone mineral densityen_US
dc.subjectChildhood cancer survivorsen_US
dc.subjectAcute lymphoblastic-leukemiaen_US
dc.subjectLong-term survivorsen_US
dc.subjectMineral densityen_US
dc.subjectChildhood-canceren_US
dc.subjectBody-compositionen_US
dc.subjectChildrenen_US
dc.subjectChemotherapyen_US
dc.subjectTherapyen_US
dc.subjectTurnoveren_US
dc.subjectPrednisoloneen_US
dc.subject.emtreeCyclophosphamideen_US
dc.subject.emtreeDexamethasoneen_US
dc.subject.emtreeEtoposideen_US
dc.subject.emtreeEtoposide derivativeen_US
dc.subject.emtreeIfosfamideen_US
dc.subject.emtreeMethotrexateen_US
dc.subject.emtreePrednisoloneen_US
dc.subject.emtreeVinca alkaloiden_US
dc.subject.emtreeAnthropometric parametersen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBody heighten_US
dc.subject.emtreeBody massen_US
dc.subject.emtreeBody weighten_US
dc.subject.emtreeBone densityen_US
dc.subject.emtreeBone growthen_US
dc.subject.emtreeBone tumoren_US
dc.subject.emtreeCancer chemotherapyen_US
dc.subject.emtreeCancer patienten_US
dc.subject.emtreeCancer radiotherapyen_US
dc.subject.emtreeChilden_US
dc.subject.emtreeChildhood canceren_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeGerm cell tumoren_US
dc.subject.emtreeHodgkin diseaseen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeLong term careen_US
dc.subject.emtreeLymphatic system tumoren_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeNeoplasmen_US
dc.subject.emtreeNonhodgkin lymphomaen_US
dc.subject.emtreeOncologyen_US
dc.subject.emtreeOsteopeniaen_US
dc.subject.emtreeOsteoporosisen_US
dc.subject.emtreePreschool childen_US
dc.subject.emtreeProspective studyen_US
dc.subject.emtreeRetinoblastomaen_US
dc.subject.emtreeScoring systemen_US
dc.subject.emtreeSoft tissue sarcomaen_US
dc.subject.emtreeSolid tumoren_US
dc.subject.meshAnthropometryen_US
dc.subject.meshAntineoplastic combined chemotherapy protocolsen_US
dc.subject.meshBody heighten_US
dc.subject.meshBody mass indexen_US
dc.subject.meshBody weighten_US
dc.subject.meshBone densityen_US
dc.subject.meshBone developmenten_US
dc.subject.meshChilden_US
dc.subject.meshChild, preschoolen_US
dc.subject.meshCross-sectional studiesen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-up studiesen_US
dc.subject.meshHumansen_US
dc.subject.meshInfanten_US
dc.subject.meshInfant, newbornen_US
dc.subject.meshMaleen_US
dc.subject.meshNeoplasm stagingen_US
dc.subject.meshNeoplasmsen_US
dc.subject.meshProspective studiesen_US
dc.subject.meshTime factorsen_US
dc.subject.meshTreatment outcomeen_US
dc.subject.scopusAcute Lymphoblastic Leukemia; Bone Density; Photon Absorptiometryen_US
dc.subject.wosOncologyen_US
dc.subject.wosHematologyen_US
dc.subject.wosPediatricsen_US
dc.titleTime-dependent alterations in growth and bone health parameters evaluated at different posttreatment periods in pediatric oncology patientsen_US
dc.typeArticle
dc.wos.quartileQ4en_US
dc.wos.quartileQ3 (Pediatrics)en_US

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