Evaluation of the hemostatic and histopathological effects of Ankaferd Blood Stopper in experimental liver injury in rats

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dc.contributor.buuauthorSatar, Nihal Y.Gül
dc.contributor.buuauthorAkkoç, Ahmet
dc.contributor.buuauthorOktay, Ayberk
dc.contributor.buuauthorTopal, Ayşe
dc.contributor.buuauthorİnan, Kıvanç
dc.contributor.departmentUludağ Üniversitesi/Veterinerlik Fakültesi/Cerrahi Bölümü.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Veterinerlik Fakültesi/Patoloji Anabilim Dalı.tr_TR
dc.contributor.scopusid55939069000tr_TR
dc.contributor.scopusid55584229300tr_TR
dc.contributor.scopusid57196860546tr_TR
dc.contributor.scopusid56357211200tr_TR
dc.contributor.scopusid55584100400tr_TR
dc.date.accessioned2023-05-23T07:52:15Z
dc.date.available2023-05-23T07:52:15Z
dc.date.issued2013-07
dc.description.abstractWe studied the hemostatic and histopathological effects, and intra-abdominal adhesion scores of a new hemostatic agent, Ankaferd Blood Stopper (ABS), in an experimental liver injury model and compared it with regenerated oxidized cellulose. Thirty-six rats were randomly assigned to ABS, oxidized cellulose (Surgicel), and control groups (n=12, each). A wedge resection was performed on the left medial lobe of the liver. In the ABS group the liver surface was sprayed with ABS, whereas in the Surgicel group the liver was covered with double-layered oxidized cellulose. In the control group, saline solution was sprayed on the cut surface. The mean bleeding time was shorter in the ABS (23.08 +/- 6.99s) and Surgicel groups (47.91 +/- 8.21s) than in the control group (223.42 +/- 57.83s). No significant difference was found in the ABS and Surgicel groups in terms of preoperative and postoperative hematocrit (hct) values (P>0.05). Whereas there was no significant difference on day 7 (P>0.05), total adhesion score of ABS group was lower than both Surgicel (P<0.05) and control groups (P<0.01) on day 14. Liver sections from ABS group displayed more favorable histopathological changes when compared with Surgicel group on day 7 and day 14. All livers in the ABS group completed their regeneration process with minimal signs of inflammation. Our findings suggest that ABS is more effective than Surgicel and control groups in achieving hemostasis and in reducing blood loss. Apart from this, ABS causes more encouraging histopathological changes and better intra-abdominal adhesion scores in rat experimental liver trauma model.en_US
dc.identifier.citationSatar, N. Y. G. vd. (2013). “Evaluation of the hemostatic and histopathological effects of Ankaferd Blood Stopper in experimental liver injury in rats”. Blood Coagulation and Fibrinolysis, 24(5), 518-524.en_US
dc.identifier.endpage524tr_TR
dc.identifier.issn0957-5235
dc.identifier.issn1473-5733
dc.identifier.issue5tr_TR
dc.identifier.pubmed23399904tr_TR
dc.identifier.scopus2-s2.0-84879900555tr_TR
dc.identifier.startpage518tr_TR
dc.identifier.urihttps://doi.org/10.1097/MBC.0b013e32835e9498
dc.identifier.urihttps://journals.lww.com/bloodcoagulation/Fulltext/2013/07000/Evaluation_of_the_hemostatic_and_histopathological.10.aspx
dc.identifier.urihttp://hdl.handle.net/11452/32740
dc.identifier.volume24tr_TR
dc.identifier.wos000326588900010tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherLippincott Williams and Wilkinsen_US
dc.relation.journalBlood Coagulation and Fibrinolysisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHematologyen_US
dc.subjectAnkaferd Blood Stopperen_US
dc.subjectBleedingen_US
dc.subjectExperimentalen_US
dc.subjectLiveren_US
dc.subjectRaten_US
dc.subjectSurgeryen_US
dc.subjectAdhesion formationen_US
dc.subjectIn-vitroen_US
dc.subjectAgentsen_US
dc.subjectEfficacyen_US
dc.subjectModelen_US
dc.subject.emtreeAnkaferd blood stopperen_US
dc.subject.emtreeHemostatic agenten_US
dc.subject.emtreeOxidized regenerated celluloseen_US
dc.subject.emtreeUnclassified drugen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeAnimal modelen_US
dc.subject.emtreeAnimal tissueen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBleeding timeen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeExperimental raten_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeHematocriten_US
dc.subject.emtreeHemostasisen_US
dc.subject.emtreeHistopathologyen_US
dc.subject.emtreeLiver injuryen_US
dc.subject.emtreeLiver regenerationen_US
dc.subject.emtreeLiver resectionen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreePeritoneum adhesionen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeRaten_US
dc.subject.emtreeWedge resectionen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBleeding timeen_US
dc.subject.meshBlood loss, surgicalen_US
dc.subject.meshCellulose, oxidizeden_US
dc.subject.meshFemaleen_US
dc.subject.meshHematocriten_US
dc.subject.meshHemostasis, surgicalen_US
dc.subject.meshLiveren_US
dc.subject.meshPlant extractsen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, sprague-dawleyen_US
dc.subject.meshTissue adhesionsen_US
dc.subject.scopusAnkaferd Blood Stopper; Gastrointestinal Hemorrhage; Endoscopic Hemostasisen_US
dc.subject.wosHematologyen_US
dc.titleEvaluation of the hemostatic and histopathological effects of Ankaferd Blood Stopper in experimental liver injury in ratsen_US
dc.typeArticle
dc.wos.quartileQ4en_US

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