A prospective, multi-center study: Factors related to the management of diabetic foot infections

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dc.contributor.authorErtuğrul, Bülent M.
dc.contributor.authorÖncül, Oral
dc.contributor.authorTülek, Necla
dc.contributor.authorWillke, Ayşe
dc.contributor.authorSaçar, Suzan
dc.contributor.authorTunçcan, Özlem Güzel
dc.contributor.authorKaya, Özlem
dc.contributor.authorÖztürk, Bülent
dc.contributor.authorTurhan, Özge
dc.contributor.authorYapar, Nur
dc.contributor.authorTüre, Mevlüt
dc.contributor.authorAkın, Fulya
dc.contributor.buuauthorYılmaz, Emel
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı.tr_TR
dc.contributor.scopusid22037135100tr_TR
dc.date.accessioned2022-03-15T06:31:18Z
dc.date.available2022-03-15T06:31:18Z
dc.date.issued2012-09
dc.description.abstractThe Turkish Association of Clinical Microbiology and Infectious Diseases, Diabetic Foot Infections Working Group conducted a prospective study to determine the factors affecting the outcomes of diabetic foot infections. A total of 96 patients were enrolled in the study. Microbiological assessment was performed in 86 patients. A total of 115 causative bacteria were isolated from 71 patients. The most frequently isolated bacterial species was Pseudomonas aeruginosa (n = 21, 18.3%). Among cases with bacterial growth, 37 patients (43%) were infected with 38 (33%) antibiotic-resistant bacteria. The mean (+/- SD) antibiotics cost was 2,220.42 (+/- 994.59) USD in cases infected with resistant bacteria, while it was 1,206.60 (+/- 1,160.6) USD in patients infected with susceptible bacteria (p < 0.001). According to the logistic regression analysis, the risk factors related to the growth of resistant bacteria were previous amputation (p = 0.018, OR = 7.229) and antibiotics administration within the last 30 days (p = 0.032, OR = 3.796); that related to the development of osteomyelitis was wound size > 4.5 cm(2) (p = 0.041, OR = 2.8); and that related to the failure of the treatment was the growth of resistant bacteria (p = 0.016, OR = 5.333). Diabetic foot osteomyelitis is usually a chronic infection and requires surgical therapy. Amputation is the accepted form of treatment for osteomyelitis. Limited limb-saving surgery and prolonged antibiotic therapy directed toward the definitive causative bacteria are most appropriate. This may decrease limb loss through amputations. As a result the infections caused by resistant bacteria may lead to a high cost of antibiotherapy, prolonged hospitalization duration, and failure of the treatment.en_US
dc.identifier.citationErtuğrul, B. M. vd. (2012). "A prospective, multi-center study: Factors related to the management of diabetic foot infections". European Journal of Clinical Microbiology & Infectious Diseases, 31(9), 2345-2352.en_US
dc.identifier.endpage2352tr_TR
dc.identifier.issn0934-9723
dc.identifier.issn1435-4373
dc.identifier.issue9tr_TR
dc.identifier.pubmed22354524tr_TR
dc.identifier.scopus2-s2.0-84866419353tr_TR
dc.identifier.startpage2345tr_TR
dc.identifier.urihttps://doi.org/10.1007/s10096-012-1574-1
dc.identifier.urihttps://link.springer.com/article/10.1007/s10096-012-1574-1
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/22354524/
dc.identifier.urihttp://hdl.handle.net/11452/25016
dc.identifier.volume31tr_TR
dc.identifier.wos000307514400032tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.collaborationYurt içitr_TR
dc.relation.collaborationSanayitr_TR
dc.relation.journalEuropean Journal of Clinical Microbiology & Infectious Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectInfectious diseasesen_US
dc.subjectMicrobiologyen_US
dc.subjectResistant staphylococcus-aureusen_US
dc.subjectRisk-factorsen_US
dc.subjectSoft-tissueen_US
dc.subjectOsteomyelitisen_US
dc.subjectDiagnosisen_US
dc.subjectUlceren_US
dc.subjectEpidemiologyen_US
dc.subjectPathogensen_US
dc.subject.emtreeAntibiotic agenten_US
dc.subject.emtreeBeta lactam antibioticen_US
dc.subject.emtreeMeticillinen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAmputationen_US
dc.subject.emtreeAntibiotic resistanceen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBacterial growthen_US
dc.subject.emtreeDiabetic foot infectionen_US
dc.subject.emtreeDrug costen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeFoot diseaseen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreeOsteomyelitisen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeProspective studyen_US
dc.subject.emtreePseudomonas aeruginosaen_US
dc.subject.emtreeRisk factoren_US
dc.subject.emtreeTreatment failureen_US
dc.subject.emtreeWounden_US
dc.subject.meshAgeden_US
dc.subject.meshAnti-bacterial agentsen_US
dc.subject.meshBacteriaen_US
dc.subject.meshBacterial infectionsen_US
dc.subject.meshDiabetic footen_US
dc.subject.meshDrug resistance, bacterialen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshProspective studiesen_US
dc.subject.meshTurkeyen_US
dc.subject.scopusDiabetic Foot; Osteomyelitis; Gangreneen_US
dc.subject.wosInfectious diseasesen_US
dc.subject.wosMicrobiologyen_US
dc.titleA prospective, multi-center study: Factors related to the management of diabetic foot infectionsen_US
dc.typeArticle
dc.wos.quartileQ2en_US

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