Expression status of let-7a and miR-335 among breast tumors in patients with and without germ-line BRCA mutations

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dc.contributor.buuauthorErtürk, Elif
dc.contributor.buuauthorÇeçener, Gülşah
dc.contributor.buuauthorEgeli, Ünal
dc.contributor.buuauthorTunca, Berrin
dc.contributor.buuauthorTezcan, Gülçin
dc.contributor.buuauthorGökgöz, Şehsuvar
dc.contributor.buuauthorTolunay, Şahsine
dc.contributor.buuauthorTaşdelen, İsmet
dc.contributor.departmentUludağ Üniversitesi/Sağlık Hizmetleri Meslek Yüksekokulu/Tıbbi Hizmetler ve Teknikler Bölümü.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Patoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-3820-424Xtr_TR
dc.contributor.orcid0000-0002-1619-6680tr_TR
dc.contributor.orcid0000-0001-7904-883Xtr_TR
dc.contributor.orcid0000-0002-5956-8755tr_TR
dc.contributor.researcheridAAP-9988-2020tr_TR
dc.contributor.researcheridABI-6078-2020tr_TR
dc.contributor.researcheridAAI-1612-2021tr_TR
dc.contributor.researcheridAAK-3371-2021tr_TR
dc.contributor.researcheridAAH-1420-2021tr_TR
dc.contributor.researcheridAAH-3843-2020tr_TR
dc.contributor.scopusid50261655300tr_TR
dc.contributor.scopusid6508156530tr_TR
dc.contributor.scopusid55665145000tr_TR
dc.contributor.scopusid6602965754tr_TR
dc.contributor.scopusid25650627600tr_TR
dc.contributor.scopusid6603238737tr_TR
dc.contributor.scopusid6602604390tr_TR
dc.contributor.scopusid9637821500tr_TR
dc.date.accessioned2022-06-15T12:18:01Z
dc.date.available2022-06-15T12:18:01Z
dc.date.issued2014-10
dc.description.abstractThe genetic factors of cancer predisposition remain elusive in the majority of familial and/or early-onset cases of breast cancer (BC). This type of BC is promoted by germ-line mutations that inactivate BRCA1 or BRCA2. On the other hand, recent studies have indicated that alterations in the levels of miRNA expression are linked to this disease. Although BRCA1 and BRCA2 gene mutations have been reported to commonly lead to alterations in genes that encode cancer-related proteins, little is known regarding the putative impact of these mutations on noncoding miRNAs. In the present study, we aimed to determine whether miRNA dysregulation is involved in the pathogenesis of BRCA-mutated BC. An expression analysis of 14 human miRNAs previously shown to be related to BC diagnosis, prognosis, and drug resistance was conducted using tissues from 60 familial and/or early-onset patients whose peripheral blood samples had been screened for BRCA1 and BRCA2 mutations through sequence analysis. Let-7a and miR-335 expression levels were significantly downregulated in the tumors of patients with a BRCA mutation compared with those of patients without a BRCA mutation (P = 0.04 and P = 0.02, respectively). Our results defined the associations between the expression status of let-7a and miR-335 and BRCA mutations. The expression analysis of these miRNAs might be used as biomarkers of the BRCA mutation status of early-onset and/or familial BC.en_US
dc.identifier.citationErtürk, E. vd. (2014). "Expression status of let-7a and miR-335 among breast tumors in patients with and without germ-line BRCA mutations". Molecular and Cellular Biochemistry, 395(1-2), 77-88.en_US
dc.identifier.endpage88tr_TR
dc.identifier.issn0300-8177
dc.identifier.issn1573-4919
dc.identifier.issue1-2tr_TR
dc.identifier.pubmed24942235tr_TR
dc.identifier.scopus2-s2.0-84906256891tr_TR
dc.identifier.startpage77tr_TR
dc.identifier.urihttps://doi.org/10.1007/s11010-014-2113-4
dc.identifier.urihttps://link.springer.com/article/10.1007/s11010-014-2113-4
dc.identifier.urihttp://hdl.handle.net/11452/27180
dc.identifier.volume395tr_TR
dc.identifier.wos000340550000007tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.bapUAP(T)-2011/1tr_TR
dc.relation.journalMolecular and Cellular Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBreast canceren_US
dc.subjectMicroRNAen_US
dc.subjectBRCA1/2 gene mutationsen_US
dc.subjectLet-7aen_US
dc.subjectMiR-335en_US
dc.subjectMicroRNA expressionen_US
dc.subjectGene-expressionen_US
dc.subjectOvarian-canceren_US
dc.subjectTurkish womenen_US
dc.subjectDiiferentiationen_US
dc.subjectProliferationen_US
dc.subjectResistanceen_US
dc.subjectPrognosisen_US
dc.subjectSignatureen_US
dc.subjectVariantsen_US
dc.subjectCell biologyen_US
dc.subject.emtreeMicroRNAen_US
dc.subject.emtreeBRCA1 proteinen_US
dc.subject.emtreeBRCA1 protein, humanen_US
dc.subject.emtreeBRCA2 proteinen_US
dc.subject.emtreeBRCA2 protein, humanen_US
dc.subject.emtreeMIRN335 microRNA, humanen_US
dc.subject.emtreeMirnlet7 microRNA, humanen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAgeden_US
dc.subject.emtreeAmino acid substitutionen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBlood samplingen_US
dc.subject.emtreeBreast canceren_US
dc.subject.emtreeCancer prognosisen_US
dc.subject.emtreeCancer resistanceen_US
dc.subject.emtreeCancer susceptibilityen_US
dc.subject.emtreeCancer tissueen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeFamilial canceren_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeFrameshift mutationen_US
dc.subject.emtreeGene expressionen_US
dc.subject.emtreeGene expression profilingen_US
dc.subject.emtreeGenetic susceptibilityen_US
dc.subject.emtreeGermline mutationen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeHuman tissueen_US
dc.subject.emtreeLet 7a geneen_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeMissense mutationen_US
dc.subject.emtreeMutational analysisen_US
dc.subject.emtreeOncogeneen_US
dc.subject.emtreeOnset ageen_US
dc.subject.emtreeReal time polymerase chain reactionen_US
dc.subject.emtreeSequence analysisen_US
dc.subject.emtreeTumor suppressor geneen_US
dc.subject.emtreeBreast tumoren_US
dc.subject.emtreeDown regulationen_US
dc.subject.emtreeGene expression regulationen_US
dc.subject.emtreeGeneticsen_US
dc.subject.emtreeGermline mutationen_US
dc.subject.emtreeMiddle ageden_US
dc.subject.emtreePathologyen_US
dc.subject.emtreePrognosisen_US
dc.subject.emtreeYoung adulten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshBRCA1 proteinen_US
dc.subject.meshBRCA2 proteinen_US
dc.subject.meshBreast neoplasmsen_US
dc.subject.meshDown-regulationen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene expression regulation, neoplasticen_US
dc.subject.meshGerm-line mutationen_US
dc.subject.meshHumansen_US
dc.subject.meshMicroRNAsen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshPrognosisen_US
dc.subject.meshYoung adulten_US
dc.subject.scopusCirculating Microrna; Stomach Neoplasms; Breast Neoplasmsen_US
dc.subject.wosCell biologyen_US
dc.titleExpression status of let-7a and miR-335 among breast tumors in patients with and without germ-line BRCA mutationsen_US
dc.typeArticle
dc.wos.quartileQ3en_US

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