Effect of the direct renin Inhibitor aliskiren in the prevention of experimental contrast-induced nephropathy in the rat

Simple item page
dc.contributor.authorKedrah, Alla Eldeen
dc.contributor.authorArı, Elif
dc.contributor.authorAlahdab, Yeşim
dc.contributor.authorMacunluoğlu, Beyza
dc.contributor.authorAtakan, Aydın
dc.contributor.authorAşıcıoğlu, Ebru
dc.contributor.authorÇakalağaoğlu, Fulya
dc.contributor.authorKoç, Mehmet
dc.contributor.buuauthorGül, Cuma Bülent
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0003-2467-9356tr_TR
dc.contributor.researcheridA-7063-2018tr_TR
dc.contributor.scopusid23988796000tr_TR
dc.date.accessioned2022-05-20T05:48:56Z
dc.date.available2022-05-20T05:48:56Z
dc.date.issued2012
dc.description.abstractBackground: Renal vasoconstriction, activated by the reninangiotensin system, plays a pivotal role in the pathogenesis of contrast-induced nephropathy (CIN). The purpose of this study was to evaluate the effect of aliskiren, a direct renin inhibitor, for the prophylaxis of experimental CIN in the rat. Methods: Thirty-two Wistar albino rats were divided into four groups of 8 rats each, namely the control (C), aliskiren (A), contrast media (CM) and aliskiren plus contrast media (ACM) groups. Aliskiren was given orally at a dose of 50 mg/kg/day once daily for 5 consecutive days. CIN was induced by intravenous administration of indomethacin, N-nitro-L-arginine methyl ester and high-osmolar contrast medium meglumine amidotrizoate. Renal function parameters, kidney histology and tubular expression of vascular endothelial growth factor were determined. Results: Mean serum creatinine was significantly lower (p < 0.001) and mean creatinine clearance was higher (p < 0.001) in the ACM group compared with the CM group. However, there were no differences between the ACM and CM groups in terms of tubular necrosis, proteinaceous casts, medullary congestion and vascular endothelial growth factor expression. Conclusion: Our preliminary data seem to suggest a potential role of aliskiren for the prophylaxis of CIN in an experimental rat model.en_US
dc.description.sponsorshipDepartment of Nephrology, Marmara University School of Medicine, Istanbul, Turkeyen_US
dc.identifier.citationKedrah, A. E. vd. (2012). "Effect of the direct renin Inhibitor aliskiren in the prevention of experimental contrast-induced nephropathy in the rat". Kidney and Blood Pressure Research, 35(6), 425-430.en_US
dc.identifier.endpage430tr_TR
dc.identifier.issn1420-4096
dc.identifier.issn1423-0143
dc.identifier.issue6tr_TR
dc.identifier.pubmed22677784tr_TR
dc.identifier.scopus2-s2.0-84861808237tr_TR
dc.identifier.startpage425tr_TR
dc.identifier.urihttps://doi.org/10.1159/000336104
dc.identifier.urihttps://www.karger.com/Article/FullText/336104
dc.identifier.urihttp://hdl.handle.net/11452/26537
dc.identifier.volume35tr_TR
dc.identifier.wos000314461100005tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.collaborationYurt içitr_TR
dc.relation.journalKidney and Blood Pressure Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPhysiologyen_US
dc.subjectUrology & nephrologyen_US
dc.subjectCardiovascular system & cardiologyen_US
dc.subjectAliskirenen_US
dc.subjectContrast-induced nephropathyen_US
dc.subjectAcute renal failureen_US
dc.subjectExperimental studyen_US
dc.subjectConverting enzyme-inhibitorsen_US
dc.subjectBlood-pressureen_US
dc.subjectHypertensionen_US
dc.subjectBlockadeen_US
dc.subjectMediaen_US
dc.subject.emtreeAliskirenen_US
dc.subject.emtreeArginine methyl esteren_US
dc.subject.emtreeCreatinineen_US
dc.subject.emtreeIndometacinen_US
dc.subject.emtreeMeglumine diatrizoateen_US
dc.subject.emtreeVasculotropinen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeAnimal modelen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeContrast induced nephropathyen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeCreatinine blood levelen_US
dc.subject.emtreeCreatinine clearanceen_US
dc.subject.emtreeDrug effecten_US
dc.subject.emtreeIn vivo studyen_US
dc.subject.emtreeKdney medulla congestionen_US
dc.subject.emtreeKidney diseaseen_US
dc.subject.emtreeKidney functionen_US
dc.subject.emtreeKidney tubule necrosisen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeProphylaxisen_US
dc.subject.emtreeProtein expressionen_US
dc.subject.emtreeRaten_US
dc.subject.emtreeSodium excretionen_US
dc.subject.emtreeTreatment durationen_US
dc.subject.meshAmidesen_US
dc.subject.meshAnimalsen_US
dc.subject.meshContrast mediaen_US
dc.subject.meshFumaratesen_US
dc.subject.meshKidney diseasesen_US
dc.subject.meshMaleen_US
dc.subject.meshRandom allocationen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, wistaren_US
dc.subject.meshReninen_US
dc.subject.meshTreatment outcomeen_US
dc.subject.scopusPercutaneous Coronary Intervention; Coronary Angiography; Kidney Diseasesen_US
dc.subject.wosPhysiologyen_US
dc.subject.wosUrology & nephrologyen_US
dc.subject.wosPeripheral vascular diseaseen_US
dc.titleEffect of the direct renin Inhibitor aliskiren in the prevention of experimental contrast-induced nephropathy in the raten_US
dc.typeArticle
dc.wos.quartileQ3en_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Gül_vd_2012.pdf
Size:
532.78 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Web of Science
Scopus