Intracerebroventricular injection of choline increases plasma oxytocin levels in conscious rats

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dc.contributor.buuauthorSavcı, Vahide
dc.contributor.buuauthorGürün, Mine Sibel
dc.contributor.buuauthorUlus, İsmail Hakkı
dc.contributor.buuauthorKıran, Burhan K.
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Farmakoloji Anabilim Dalı.tr_TR
dc.contributor.researcheridAAG-8716-2019tr_TR
dc.contributor.researcheridD-5340-2015tr_TR
dc.date.accessioned2021-07-05T11:38:17Z
dc.date.available2021-07-05T11:38:17Z
dc.date.issued1996-02-12
dc.description.abstractIn the present study, we examined the effect of intracerebroventricularly (i.c.v.) injected choline on both basal and stimulated oxytocin release in conscious rats. I.c.v. injection of choline (50-150 mu g) caused time- and dose-dependent increases in plasma oxytocin levels under normal conditions. The increase in plasma oxytocin levels in response to i.c.v. choline (150 mu g) was greatly attenuated by the pretreatment of rats with atropine (10 mu g; i.c.v.), muscarinic receptor antagonist. Mecamylamine (50 mu g; i.c.v.), a nicotinic receptor antagonist, failed to suppress the effect of 150 mu g choline on oxytocin levels. Pretreatment of rats with 20 mu g of hemicholinium-3 (HC-3), a specific inhibitor of choline uptake into nerve terminals, greatly attenuated the increase in plasma oxytocin levels in response to i.c.v. choline injection. Osmotic stimuli induced by either oral administration of 1 mi hypertonic saline (3 M) following 24-h dehydration of rats (type 1) or an i.c.v. injection of hypertonic saline (1 M) (type 2) increased plasma oxytocin levels significantly, but hemorrhage did not alter basal oxytocin concentrations. The i.c.v. injection of choline (50, 150 mu g) under these conditions caused an additional and significant increase in plasma oxytocin concentrations beyond that produced by choline in normal conditions. These data show that choline can increase plasma oxytocin concentrations through the stimulation of central cholinergic muscarinic receptors by presynaptic mechanisms and enhance the stimulated oxytocin release.en_US
dc.identifier.citationSavcı, V. vd. (1996). "Intracerebroventricular injection of choline increases plasma oxytocin levels in conscious rats". Brain Research, 709(1), 97-102.en_US
dc.identifier.endpage102tr_TR
dc.identifier.issn0006-8993
dc.identifier.issue1tr_TR
dc.identifier.pubmed8869561tr_TR
dc.identifier.scopus2-s2.0-17044455791tr_TR
dc.identifier.startpage97tr_TR
dc.identifier.urihttps://doi.org/10.1016/0006-8993(95)01308-3
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/0006899395013083
dc.identifier.urihttp://hdl.handle.net/11452/21073
dc.identifier.volume709tr_TR
dc.identifier.wosA1996TX90900012tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherElsevier Science BVen_US
dc.relation.journalBrain Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNeurosciences & neurologyen_US
dc.subjectCholineen_US
dc.subjectOxytocinen_US
dc.subjectMuscarinicen_US
dc.subjectNicotinicen_US
dc.subjectHemicholinium-3en_US
dc.subjectOsmotic stimulationen_US
dc.subjectHemorrhageen_US
dc.subjectTyrosine-hydroxylaseen_US
dc.subjectReleaseen_US
dc.subjectAcetylcholineen_US
dc.subjectVasopressinen_US
dc.subjectNeuronsen_US
dc.subjectStimulationen_US
dc.subjectActivationen_US
dc.subjectHemorrhageen_US
dc.subjectLecithinen_US
dc.subjectNucleusen_US
dc.subject.wosNeurosciencesen_US
dc.titleIntracerebroventricular injection of choline increases plasma oxytocin levels in conscious ratsen_US
dc.typeArticle

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