Relationship between disease severity and D-dimer levels measured with two different methods in pulmonary embolism patients

Simple item page
dc.contributor.buuauthorCoşkun, Funda
dc.contributor.buuauthorYılmaz, Dilber Durmaz
dc.contributor.buuauthorUrsavaş, Ahmet
dc.contributor.buuauthorUzaslan, Esra Kunt
dc.contributor.buuauthorEge, Ercüment
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0003-3604-8826tr_TR
dc.contributor.researcheridAAD-1271-2019tr_TR
dc.contributor.researcheridAAI-3169-2021tr_TR
dc.contributor.researcheridAAI-1004-2021tr_TR
dc.contributor.scopusid21734137500tr_TR
dc.contributor.scopusid36246929800tr_TR
dc.contributor.scopusid8329319900tr_TR
dc.contributor.scopusid8761653500tr_TR
dc.contributor.scopusid6701341320tr_TR
dc.date.accessioned2022-07-07T07:21:31Z
dc.date.available2022-07-07T07:21:31Z
dc.date.issued2010-06
dc.description.abstractPulmonary embolism (PE) is diagnosed with increasing frequency nowadays due to advances in the diagnostic methods and the increased awareness of the disease. There is a tendency to use non invasive diagnostic methods for all diseases. D-dimer is a fibrin degradation product. We aimed to detect the relationship between disease severity and the D-dimer levels measured with two different methods. We compared D-dimer levels in cases of massive vs. non-massive PE. A total of 89 patients who were diagnosed between 2006 and 2008 were included in the study. Group 1 included patients whose D-dimer levels were measured with the immunoturbidimetric polyclonal antibody method (D-dimerPLUS (R)), while Group 2 patients made use of the immunoturbidimetric monoclonal antibody method (InnovanceD-DIMER (R)). In each group, the D-dimer levels of those with massive and non-massive PE were compared, using the Mann Whitney U test. The mean age of Group 1 (25F/26M) was 56.0 +/- 17.9 years, and that of Group 2 (22F/16M) was 52.9 +/- 17.9 years. There was no statistical difference in gender and mean age between the two groups (p > 0.05). In Group 1, the mean D-dimer level of massive cases (n = 7) was 1444.9 +/- 657.9 mu g/L and that of non-massive PE (n = 34) was 1304.7 +/- 350.5 mu g/L (p > 0.05). In Group 2, the mean D-dimer level of massive cases (n = 6) was 9.7 +/- 2.2 mg/L and that of non-massive PE (n = 32) was 5.9 +/- 1.3 mg/L (p < 0.05). The mean D-dimer levels of massive cases as measured with the immunoturbidimetric monoclonal antibody method were significantly higher. Pulmonary embolism patients whose D-dimer levels are higher (especially higher than 6.6 mg/L) should be considered as possibly having massive embolism. Diagnostic procedures and management can be planned according to this finding.en_US
dc.identifier.citationCoşkun, F. vd. (2010). "Relationship between disease severity and D-dimer levels measured with two different methods in pulmonary embolism patients". Multidisciplinary Respiratory Medicine, 5(3), 168-172.en_US
dc.identifier.endpage172tr_TR
dc.identifier.issn2049-6958
dc.identifier.issue3tr_TR
dc.identifier.pubmed22958319tr_TR
dc.identifier.scopus2-s2.0-77954472782tr_TR
dc.identifier.startpage168tr_TR
dc.identifier.urihttps://doi.org/10.1186/2049-6958-5-3-168
dc.identifier.urihttps://mrmjournal.biomedcentral.com/articles/10.1186/2049-6958-5-3-168
dc.identifier.urihttp://hdl.handle.net/11452/27771
dc.identifier.volume5tr_TR
dc.identifier.wos000279761200003tr_TR
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherPagerpress Publicationen_US
dc.relation.bapBAPen_US
dc.relation.journalMultidisciplinary Respiratory Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectD-dimeren_US
dc.subjectMassive pulmonary embolismen_US
dc.subjectPulmonary embolismen_US
dc.subjectDeep-vein thrombosisen_US
dc.subjectVenous thromboembolismen_US
dc.subjectExclusionen_US
dc.subjectDiagnosisen_US
dc.subjectMortalityen_US
dc.subjectFibrinen_US
dc.subjectAssayen_US
dc.subjectModelen_US
dc.subjectRespiratory systemen_US
dc.subject.emtreeD dimeren_US
dc.subject.emtreeMonoclonal antibodyen_US
dc.subject.emtreePolyclonal antibodyen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAgeden_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeDisease severityen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeHeart right ventricle functionen_US
dc.subject.emtreeHemodynamicsen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeImmunological techniqueen_US
dc.subject.emtreeLung embolismen_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeNon invasive measurementen_US
dc.subject.emtreeRank sum testen_US
dc.subject.emtreeTurbidimetryen_US
dc.subject.emtreeArea under the curveen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDiagnostic test accuracy studyen_US
dc.subject.emtreeDiastolic blood pressureen_US
dc.subject.emtreeHeart rateen_US
dc.subject.emtreeImmunological proceduresen_US
dc.subject.emtreeImmunoturbidimetric monoclonalen_US
dc.subject.emtreeAntibody methoden_US
dc.subject.emtreeImmunoturbidimetric polyclonal antibody methoden_US
dc.subject.emtreeLung hemodynamicsen_US
dc.subject.emtreeReceiver operating characteristicen_US
dc.subject.emtreeSensitivity and specificityen_US
dc.subject.emtreeSystolic blood pressureen_US
dc.subject.scopusLung Embolism; Fibrin Fragment D; Vein Thrombosisen_US
dc.subject.wosRespiratory systemen_US
dc.titleRelationship between disease severity and D-dimer levels measured with two different methods in pulmonary embolism patientsen_US
dc.typeArticle

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Coşkun_vd_2010.pdf
Size:
161.32 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Web of Science
Scopus