Unilateral radius aplasia due to lamotrigine and oxcarbazepine use in pregnancy

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dc.contributor.buuauthorÇetinkaya, Merih
dc.contributor.buuauthorÖzkan, Hilal
dc.contributor.buuauthorKöksal, Nilgün
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Neonatoloji Anabilim Dalı.tr_TR
dc.contributor.scopusid23994946300tr_TR
dc.contributor.scopusid16679325400tr_TR
dc.contributor.scopusid7003323615tr_TR
dc.date.accessioned2022-06-20T11:07:46Z
dc.date.available2022-06-20T11:07:46Z
dc.date.issued2008
dc.description.abstractLamotrigine (LTG) has been used in epilepsia patients for treatment of partial seizures. It can cross the placenta and there are limited data about its use in pregnancy and foetal adverse effects. Extremity and cardiac malformations, dysmorphic facial appearance, coanal atresia and upper respiratory and gastrointestinal anomalies have been reported because of LTG use in pregnancy. Oxcarbazepine (OXC) is one of the new antiepileptic agents. Although the drug and its metabolites can easily pass from placenta to the foetus, available data suggest that it can be safely used during pregnancy because no teratogenicity has been reported. One infant with atrial septal defect and patent ductus arteriosus due to use of LTG and OXC in pregnancy has been reported in literature. Here, we report a female infant with micrognatia, low-set ears, facial dysmorphism and unilateral radius aplasia born to a mother who used LTG 100 mg/day and OXC 1200 mg/day during pregnancy for seizures. To our knowledge, this is the first major anomaly case associated with the combined use of these drugs. This case can provide useful data about the teratogenicity of LTG and OXC combination therapy.en_US
dc.identifier.citationÇetinkaya, M. vd. (2008). "Unilateral radius aplasia due to lamotrigine and oxcarbazepine use in pregnancy". Journal of Maternal-Fetal and Neonatal Medicine, 21(12), 927-930.en_US
dc.identifier.endpage930tr_TR
dc.identifier.issn1476-7058
dc.identifier.issn1476-4954
dc.identifier.issue12tr_TR
dc.identifier.pubmed19065466tr_TR
dc.identifier.scopus2-s2.0-57449120934tr_TR
dc.identifier.startpage927tr_TR
dc.identifier.urihttps://doi.org/10.1080/14767050802366210
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.1080/14767050802366210
dc.identifier.urihttp://hdl.handle.net/11452/27314
dc.identifier.volume21tr_TR
dc.identifier.wos000262645800013tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherTaylor & Francisen_US
dc.relation.journalJournal of Maternal-Fetal and Neonatal Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectObstetrics & gynecologyen_US
dc.subjectLamotrigineen_US
dc.subjectOxcarbazepineen_US
dc.subjectPolytherapyen_US
dc.subjectPregnancyen_US
dc.subjectUnilateral radius aplasiaen_US
dc.subjectAntiepileptic drugsen_US
dc.subjectEpilepsyen_US
dc.subjectTeratogenicityen_US
dc.subjectMalformationsen_US
dc.subjectExposureen_US
dc.subject.emtreeCarbamazepineen_US
dc.subject.emtreeLamotrigineen_US
dc.subject.emtreeOxcarbazepineen_US
dc.subject.emtreeApgar scoreen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBlood chemistryen_US
dc.subject.emtreeBone radiographyen_US
dc.subject.emtreeCase reporten_US
dc.subject.emtreeCesarean sectionen_US
dc.subject.emtreeChromosome analysisen_US
dc.subject.emtreeDrug substitutionen_US
dc.subject.emtreeDrug withdrawalen_US
dc.subject.emtreeFace dysmorphiaen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeFlexion contractureen_US
dc.subject.emtreeGestation perioden_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeLow set earen_US
dc.subject.emtreeMicrognathiaen_US
dc.subject.emtreeNewbornen_US
dc.subject.emtreeNuclear magnetic resonance imagingen_US
dc.subject.emtreePhysical examinationen_US
dc.subject.emtreePositive end expiratory pressureen_US
dc.subject.emtreePregnancyen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeRadius aplasiaen_US
dc.subject.emtreeSeizureen_US
dc.subject.meshAnticonvulsantsen_US
dc.subject.meshCarbamazepineen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshInfant, newbornen_US
dc.subject.meshMaxillofacial abnormalitiesen_US
dc.subject.meshPregnancyen_US
dc.subject.meshRadiusen_US
dc.subject.meshTriazinesen_US
dc.subject.meshUpper extremity deformitiesen_US
dc.subject.meshCongenitalen_US
dc.subject.scopusAnticonvulsants; Valproic Acid; Lamotrigineen_US
dc.subject.wosObstetrics & gynecologyen_US
dc.titleUnilateral radius aplasia due to lamotrigine and oxcarbazepine use in pregnancyen_US
dc.typeArticle
dc.wos.quartileQ4en_US

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