Kikuchi-Fujimoto hastalığı; 3 olgu sunumu
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Date
2019-04-08
Authors
Selvioğlu, Elif
Yavaşoğlu, İrfan
Bolaman, Ali Zahit
Meteoğlu, İbrahim
Yiğitbaşı, Esin
Journal Title
Journal ISSN
Volume Title
Publisher
Bursa Uludağ Üniversitesi
Abstract
Kikuchi-Fujimoto hastalığı veya histiyositik nekrotizan lenfadenit sıklıkla genç kadınlarda görülen, kendini sınırlayan, benign seyirli bir hastalıktır. Genellikle servikal lenfadenopati ile prezente olur1. Deri, göz ve kemik iliği lokalizasyonlarının da dahil olduğu, hastalığın ekstranodal bir uzantısı nadiren tanımlanır2. Çoğu hastada lökopeni veya nötropeni vardır2. Tanı için lenf nodu biyopsisi gerekmektedir. Histolojik incelemede, çok sayıda CD68 + / myeloperoksidaz (MPO) + histiyosit, CD68 + / CD123 + plazmasitoid dendritik hücreler görülür2. Hastalık klinik olarak Sistemik Lupus Eritematozus, tüberküloz veya lenfoma ile karışabilir. Nadiren SLE ile birliktelik gösterebilir, kemik iliği veya yaygın lenfadenopati ile seyredebilir. Burada tek merkezde rastlanan 3 olgu ve farklı klinik seyirleri sunulmuştur.
Kikuchi-Fujimoto's disease or histiocytic necrotizing lymphadenitis is a self-limited, benign disease that often occurs in young women. Usually it presents with cervical lymphadenopathy. An extranodal extension of the disease, including involvement of skin, eye, and bone marrow localizations, has been rarely described1. Most patients have leukopenia or neutropenia1. Need for lymph node biopsy for diagnosis. Histological examination revealed numerous CD68+/ myeloperoxidase (MPO) + histiocytes, CD68 + / CD123 + plasmacytoid dendritic cells1.The disease can be clinically mixed with systemic lupus erythematosus, tuberculosis or lymphoma. It may rarely coexist with SLE, and may be associated with bone marrow or extensive lymph node involvement. Here, we present 3 cases in one center and different clinical course.
Kikuchi-Fujimoto's disease or histiocytic necrotizing lymphadenitis is a self-limited, benign disease that often occurs in young women. Usually it presents with cervical lymphadenopathy. An extranodal extension of the disease, including involvement of skin, eye, and bone marrow localizations, has been rarely described1. Most patients have leukopenia or neutropenia1. Need for lymph node biopsy for diagnosis. Histological examination revealed numerous CD68+/ myeloperoxidase (MPO) + histiocytes, CD68 + / CD123 + plasmacytoid dendritic cells1.The disease can be clinically mixed with systemic lupus erythematosus, tuberculosis or lymphoma. It may rarely coexist with SLE, and may be associated with bone marrow or extensive lymph node involvement. Here, we present 3 cases in one center and different clinical course.
Description
Keywords
Kikuchi, Lupus, Lenfadenopati, Fujimoto, Lenfoma, Lymphadenopathy, Lymphoma
Citation
Selvioğlu, E. vd. (2019). "Kikuchi-Fujimoto hastalığı; 3 olgu sunumu". Uludağ Üniversitesi Tıp Fakültesi Dergisi, 45(2), 211-213.