Otoimmün hepatit tanılı erişkin hastaların değerlendirilmesi: Tek merkez deneyimi
Date
2024-03-11
Authors
Ertem, Aytül Coşar
Öztürk, Tuba Erürker
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Otoimmün hepatit (OİH), etkilenen hastaların çoğunda immünsüpresif ajanların gerekli olduğu, immün aracılı kronik inflamatuar bir karaciğer hastalığıdır. Mevcut çalışmada, OİH tanısı ile takipli hastalarımızın tanı anındaki klinik ve demografik özellikleri, laboratuvar değerleri, otoantikorların dağılımı, karaciğer biyopsi analizleri ve histopatolojik özellikleri, OİH'e eşlik eden diğer karaciğer varyant ve otoimmün hastalıkların dağılımının değerlendirilmesi ve bizim merkezimizin sonuçlarının literatür eşliğinde tartışılması amaçlanmıştır. Bu retrospektif, kesitsel çalışmaya 01.01.2010-30.06.2017 tarihleri arasında merkezimize başvuran ve OİH tanısı alan 202 hasta dahil edilmiştir. Hastaların bilgileri hastane yönetim bilgi sisteminden geriye yönelik olarak taranıp kaydedilmiştir. Hastaların 174'ü (%86) kadın, 28'i ise (%13.9) erkekti. Hastaların medyan tanı yaşı 46 olarak bulundu. Hastaların tanı konma yaşının sıklıkla orta yaş grubunda (41-60 yaş) olduğu saptandı. OİH tanılı hastalarda otoantikorlardan en sık antinükleer antikor (ANA) (%86) pozitifliği saptandı. Hastalarımızın en sık tip-1 OİH olduğu saptandı. Ayrıca Hashimato tiroiditi (%31.6) en sık eşlik eden otoimmün hastalık, primer biliyer siroz (%56) en sık eşlik eden karaciğer varyant hastalığı olarak bulunmuştur. Sonuç olarak OİH, günümüzde sıklığı giderek artan, tüm yaş, cinsiyet ve etnik grupları etkileyebilen, kronik, otoimmün bir karaciğer hastalığıdır. Erken tanı ve tedavi, hastalık yönetiminde önemlidir. Bu açıdan hastalığın etyopatogenezini ve OİH'e eşlik eden hastalıkları bilmenin erken tanı ve doğru tedavi açısından önemli olduğu açıktır.
Autoimmune hepatitis (AIH) is an immune-mediated chronic inflammatory liver disease for which immunosuppressive agents are required in most affected patients. In the current study, it was aimed to evaluate the clinical and demographic characteristics, laboratory values, distribution of autoantibodies, liver biopsy analyzes and histopathological features of our patients diagnosed with AIH and the distribution of other liver variant and autoimmune diseases accompanying AIH, and discuss the results of our center in the light of the literature. This retrospective, cross-sectional study included 202 patients who applied to our center between 01.01.2010 and 30.06.2017 and were diagnosed with AIH. The patients' information was scanned and recorded retrospectively from the hospital management information system. 174 (86%) of the patients were female and 28 (13.9%) were male. The median age of the patients at diagnosis was 46 years. It was determined that the age at which patients were diagnosed was mostly in the middle age group (41-60 years). Among the autoantibodies, antinuclear antibody (ANA) positivity was most frequently detected in patients diagnosed with AIH (86%). Our patients were found to have type-1 AIH most frequently. Additionally, Hashimoto's thyroiditis (31.6%) was found to be the most common accompanying autoimmune disease, and primary biliary cirrhosis (56%) was found to be the most common accompanying liver variant disease. In conclusion, AIH is a chronic, autoimmune liver disease that is increasingly common today and can affect all age, gender and ethnic groups. Early diagnosis and treatment are important in disease management. In this respect, it is clear that knowing the etiopathogenesis of the disease and the diseases accompanying AIH is important for early diagnosis and correct treatment.
Autoimmune hepatitis (AIH) is an immune-mediated chronic inflammatory liver disease for which immunosuppressive agents are required in most affected patients. In the current study, it was aimed to evaluate the clinical and demographic characteristics, laboratory values, distribution of autoantibodies, liver biopsy analyzes and histopathological features of our patients diagnosed with AIH and the distribution of other liver variant and autoimmune diseases accompanying AIH, and discuss the results of our center in the light of the literature. This retrospective, cross-sectional study included 202 patients who applied to our center between 01.01.2010 and 30.06.2017 and were diagnosed with AIH. The patients' information was scanned and recorded retrospectively from the hospital management information system. 174 (86%) of the patients were female and 28 (13.9%) were male. The median age of the patients at diagnosis was 46 years. It was determined that the age at which patients were diagnosed was mostly in the middle age group (41-60 years). Among the autoantibodies, antinuclear antibody (ANA) positivity was most frequently detected in patients diagnosed with AIH (86%). Our patients were found to have type-1 AIH most frequently. Additionally, Hashimoto's thyroiditis (31.6%) was found to be the most common accompanying autoimmune disease, and primary biliary cirrhosis (56%) was found to be the most common accompanying liver variant disease. In conclusion, AIH is a chronic, autoimmune liver disease that is increasingly common today and can affect all age, gender and ethnic groups. Early diagnosis and treatment are important in disease management. In this respect, it is clear that knowing the etiopathogenesis of the disease and the diseases accompanying AIH is important for early diagnosis and correct treatment.
Description
Keywords
Otoantikor, Epidemiyoloji, Otoimmün hepatit, Autoimmune hepatitis, Autoantibody, Epidemiology
Citation
Ertem, A. C. vd. (2024). "Otoimmün hepatit tanılı erişkin hastaların değerlendirilmesi: Tek merkez deneyimi". Uludağ Üniversitesi Tıp Fakültesi Dergisi, 50(1), 23-28.