Solunum güçlüğü ile seyreden buzağı pneumonilerini̇n tedavisinde clenbuterol'ün etkisi
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Date
1998
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Uludağ Üniversitesi
Abstract
Bu araştırmada solunum güçlüğü (dispne) ile seyreden 2-3 aylık, 20 bronkopnömonili buzağıda clenbuterolün kısa süreli etkileri klinik düzeyde değerlendirildi. Bu amaçla her bir buzağıya 0.8 μg/kg dozunda, intravenöz yolla clenbuterol uygulandı. Uygulama sonrası 5. , 10., 15., 20., 25. ve 30. dakikalarda klinik muayeneler tekrarlandı ve solunum güçlüğündeki değişiklikler kaydedildi. Kalp frekansı ve solunum sayısının clenbuterolün etkisiyle kontrol değerlerine göre azaldığı (p<0.05); buna paralel olarak klinik hastalık skorlarında da zamanlar arasında istatistiki düzeyde azalma (p<0.05) olduğu saptandı. Birer olguda 5. ve 25. dakikalarda, beş olguda 10.dakikada, üç olguda da 15.dakikada dispne halinin ortadan kalktığı, 10 olguda ise gürültülü solunumun şiddetinin azalmasıyla birlikte dispnenin devam ettiği belirlendi. Gözlem periyodu sonrasında buzağılara antibiyotik, sıvı tedavisi ve anti-inflamatuar ilaçlar uygulandı. Buzağılardan ikisi gözlem periyodunun 30. dakikasında, biri de 12. saat içinde öldü. Bu araştırma ile clenbuterolün dispne ile seyreden buzağı pnömonilerinin acil tedavisinde dispnenin ortadan kaldırılabilmesi amacıyla kullanılabileceği sonucuna varıldı.
In this study, early effects of clenbuterol were clinicalIy evaluated in 20 pneumonic calves, aged from 2-3 month, with dyspnea. For this purpose clenbuterol was given at the dose of 0.8 μg/kg intravenously for each affected calf. Clinical examinations were done and changes of dyspnea status were noted at the 5th, 10th, 15th, 20th, 25th and 30th minutes after the administration of clenbuterol. It was observed that heart and respiratory rate were reduced as compared to the control values (p<0.05); additionally, the clinical index scores were significantly decreased as well (p<0.05). It was determined that dyspnea status were disappeared at the 5th and 25th minutes in two calves, at the 10th minute in five calves, at the 15th minute in three calves; dyspnea was lasted although the severity of wheez'y respiration was decrased in the rest of calves. After monitoring period, antibiotics, fluids and anti-inflammatory drugs were given to each calf with dyspnea. Two of them died at the 30th minutes of monitoring period, one of them died within 12th hour. It was concluded that clenbuterol might be used to treat the pneumonic calves with dyspnea.
In this study, early effects of clenbuterol were clinicalIy evaluated in 20 pneumonic calves, aged from 2-3 month, with dyspnea. For this purpose clenbuterol was given at the dose of 0.8 μg/kg intravenously for each affected calf. Clinical examinations were done and changes of dyspnea status were noted at the 5th, 10th, 15th, 20th, 25th and 30th minutes after the administration of clenbuterol. It was observed that heart and respiratory rate were reduced as compared to the control values (p<0.05); additionally, the clinical index scores were significantly decreased as well (p<0.05). It was determined that dyspnea status were disappeared at the 5th and 25th minutes in two calves, at the 10th minute in five calves, at the 15th minute in three calves; dyspnea was lasted although the severity of wheez'y respiration was decrased in the rest of calves. After monitoring period, antibiotics, fluids and anti-inflammatory drugs were given to each calf with dyspnea. Two of them died at the 30th minutes of monitoring period, one of them died within 12th hour. It was concluded that clenbuterol might be used to treat the pneumonic calves with dyspnea.
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Keywords
Clenbuterol, Pnömoni, Solunum güçlüğü, Buzağı, Pneumonia, Dyspnea, Calves
Citation
Yılmaz, Z. vd. (1998). “Solunum güçlüğü ile seyreden buzağı pneumonilerini̇n tedavisinde clenbuterol'ün etkisi”. Uludağ Üniversitesi Veteriner Fakültesi Dergisi, 17(1-2-3), 79-86.